Ontogeny of substance p-containing structures in the ocular tissue of the rat: An immunohistochemical analysis
The ontogeny of the substance P-like immunoreactivity (SPI) containing system in the ocular tissue of the rat was examined by means of the indirect immunofluorescence method. SPI-containing amacrine cells first appeared at postnatal day 4 and displaced SPI-containing amacrine cells at postnatal day...
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| Veröffentlicht in: | Brain research 1984-04, Vol.13 (2), p.275-281 |
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| creator | Sakiyama, Tadao Kuwayama, Yasuaki Ishimoto, Ichiro Sasaoka, Atsuko Shiosaka, Sadao Tohyama, Masaya Manabe, Reizo Shiotani, Yahe |
| description | The ontogeny of the substance P-like immunoreactivity (SPI) containing system in the ocular tissue of the rat was examined by means of the indirect immunofluorescence method. SPI-containing amacrine cells first appeared at postnatal day 4 and displaced SPI-containing amacrine cells at postnatal day 5. After this time, they developed markedly reaching their maximum content and distribution at postnatal day 14. On the other hand, SPI-containing cells in the trigeminal ganglion were first seen at gestational day 17 and reached their maximum content at birth. SPI-containing fibers in the cornea and uvea were first observed at gestational day 17–19. The SPI-containing fibers in the iris reached their maximum content at birth, while those in the cornea, choroid and ciliary body were fully developed at postnatal day 3. In the adult rats, numerous SPI structures were still seen in the ocular tissue, retina, cornea and uvea.
These findings suggest that SPI might play some role in the developing ocular tissue in addition to its neurotransmitter or neuromodulator role in the adult, because SPI structures appear in the retina before establishment of synaptogenesis and in the cornea and uvea during the fetal stage. |
| doi_str_mv | 10.1016/0165-3806(84)90162-7 |
| format | Article |
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These findings suggest that SPI might play some role in the developing ocular tissue in addition to its neurotransmitter or neuromodulator role in the adult, because SPI structures appear in the retina before establishment of synaptogenesis and in the cornea and uvea during the fetal stage.</description><identifier>ISSN: 0165-3806</identifier><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0165-3806(84)90162-7</identifier><identifier>PMID: 6202377</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject><![CDATA[Animals ; Animals, Newborn - growth & development ; Biological and medical sciences ; Choroid - growth & development ; Ciliary Body - growth & development ; Cornea - growth & development ; Eye - growth & development ; Eye and associated structures. Visual pathways and centers. Vision ; Female ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; immunohistochemistry ; Iris - growth & development ; Male ; ocular tissue ; ontogeny ; rat ; Rats ; Retina - growth & development ; substance P ; Substance P - physiology ; Trigeminal Ganglion - growth & development ; Uvea - growth & development ; Vertebrates: nervous system and sense organs]]></subject><ispartof>Brain research, 1984-04, Vol.13 (2), p.275-281</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-256e9d1113c7433e1ff444275560e3b99b9c7586d840fd1bc89e4af5ac07bdb13</citedby><cites>FETCH-LOGICAL-c520t-256e9d1113c7433e1ff444275560e3b99b9c7586d840fd1bc89e4af5ac07bdb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8878281$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6202377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakiyama, Tadao</creatorcontrib><creatorcontrib>Kuwayama, Yasuaki</creatorcontrib><creatorcontrib>Ishimoto, Ichiro</creatorcontrib><creatorcontrib>Sasaoka, Atsuko</creatorcontrib><creatorcontrib>Shiosaka, Sadao</creatorcontrib><creatorcontrib>Tohyama, Masaya</creatorcontrib><creatorcontrib>Manabe, Reizo</creatorcontrib><creatorcontrib>Shiotani, Yahe</creatorcontrib><title>Ontogeny of substance p-containing structures in the ocular tissue of the rat: An immunohistochemical analysis</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The ontogeny of the substance P-like immunoreactivity (SPI) containing system in the ocular tissue of the rat was examined by means of the indirect immunofluorescence method. SPI-containing amacrine cells first appeared at postnatal day 4 and displaced SPI-containing amacrine cells at postnatal day 5. After this time, they developed markedly reaching their maximum content and distribution at postnatal day 14. On the other hand, SPI-containing cells in the trigeminal ganglion were first seen at gestational day 17 and reached their maximum content at birth. SPI-containing fibers in the cornea and uvea were first observed at gestational day 17–19. The SPI-containing fibers in the iris reached their maximum content at birth, while those in the cornea, choroid and ciliary body were fully developed at postnatal day 3. In the adult rats, numerous SPI structures were still seen in the ocular tissue, retina, cornea and uvea.
These findings suggest that SPI might play some role in the developing ocular tissue in addition to its neurotransmitter or neuromodulator role in the adult, because SPI structures appear in the retina before establishment of synaptogenesis and in the cornea and uvea during the fetal stage.</description><subject>Animals</subject><subject>Animals, Newborn - growth & development</subject><subject>Biological and medical sciences</subject><subject>Choroid - growth & development</subject><subject>Ciliary Body - growth & development</subject><subject>Cornea - growth & development</subject><subject>Eye - growth & development</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>immunohistochemistry</subject><subject>Iris - growth & development</subject><subject>Male</subject><subject>ocular tissue</subject><subject>ontogeny</subject><subject>rat</subject><subject>Rats</subject><subject>Retina - growth & development</subject><subject>substance P</subject><subject>Substance P - physiology</subject><subject>Trigeminal Ganglion - growth & development</subject><subject>Uvea - growth & development</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0165-3806</issn><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2PFCEQhonRrOPqP9CEgzF6aAWabmgPJpuNX8kme9EzoenqHUw3jBSYzL-XdiZz9EAI1PNWigdCXnL2njPef6ira1rN-rdavhvqSTTqEdlxrUTTC8kek90FeUqeIf5ijPFW8yty1QsmWqV2JNyHHB8gHGmcKZYRsw0O6KFxMWTrgw8PFHMqLpcESH2geQ80urLYRLNHLLAlt8tk80d6E6hf1xLi3mOObg-rd3ahNtjliB6fkyezXRBenPdr8vPL5x-335q7-6_fb2_uGtcJlhvR9TBMnPPWKdm2wOdZSilU1_UM2nEYxsGpTveTlmye-Oj0ANLOnXVMjdPI22vy5tT3kOLvApjN6tHBstgAsaDRnPWdEkMF5Ql0KSImmM0h-dWmo-HMbJrN5tBsDo2W5p9mo2rs1bl_GVeYLqGz11p_fa5brO-fU7Xq8YJprbTQ25ifThhUF388JIPOQ_2AySdw2UzR_3-OvzyGmj8</recordid><startdate>198404</startdate><enddate>198404</enddate><creator>Sakiyama, Tadao</creator><creator>Kuwayama, Yasuaki</creator><creator>Ishimoto, Ichiro</creator><creator>Sasaoka, Atsuko</creator><creator>Shiosaka, Sadao</creator><creator>Tohyama, Masaya</creator><creator>Manabe, Reizo</creator><creator>Shiotani, Yahe</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198404</creationdate><title>Ontogeny of substance p-containing structures in the ocular tissue of the rat: An immunohistochemical analysis</title><author>Sakiyama, Tadao ; Kuwayama, Yasuaki ; Ishimoto, Ichiro ; Sasaoka, Atsuko ; Shiosaka, Sadao ; Tohyama, Masaya ; Manabe, Reizo ; Shiotani, Yahe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-256e9d1113c7433e1ff444275560e3b99b9c7586d840fd1bc89e4af5ac07bdb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Animals, Newborn - growth & development</topic><topic>Biological and medical sciences</topic><topic>Choroid - growth & development</topic><topic>Ciliary Body - growth & development</topic><topic>Cornea - growth & development</topic><topic>Eye - growth & development</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>immunohistochemistry</topic><topic>Iris - growth & development</topic><topic>Male</topic><topic>ocular tissue</topic><topic>ontogeny</topic><topic>rat</topic><topic>Rats</topic><topic>Retina - growth & development</topic><topic>substance P</topic><topic>Substance P - physiology</topic><topic>Trigeminal Ganglion - growth & development</topic><topic>Uvea - growth & development</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakiyama, Tadao</creatorcontrib><creatorcontrib>Kuwayama, Yasuaki</creatorcontrib><creatorcontrib>Ishimoto, Ichiro</creatorcontrib><creatorcontrib>Sasaoka, Atsuko</creatorcontrib><creatorcontrib>Shiosaka, Sadao</creatorcontrib><creatorcontrib>Tohyama, Masaya</creatorcontrib><creatorcontrib>Manabe, Reizo</creatorcontrib><creatorcontrib>Shiotani, Yahe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakiyama, Tadao</au><au>Kuwayama, Yasuaki</au><au>Ishimoto, Ichiro</au><au>Sasaoka, Atsuko</au><au>Shiosaka, Sadao</au><au>Tohyama, Masaya</au><au>Manabe, Reizo</au><au>Shiotani, Yahe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogeny of substance p-containing structures in the ocular tissue of the rat: An immunohistochemical analysis</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1984-04</date><risdate>1984</risdate><volume>13</volume><issue>2</issue><spage>275</spage><epage>281</epage><pages>275-281</pages><issn>0165-3806</issn><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The ontogeny of the substance P-like immunoreactivity (SPI) containing system in the ocular tissue of the rat was examined by means of the indirect immunofluorescence method. SPI-containing amacrine cells first appeared at postnatal day 4 and displaced SPI-containing amacrine cells at postnatal day 5. After this time, they developed markedly reaching their maximum content and distribution at postnatal day 14. On the other hand, SPI-containing cells in the trigeminal ganglion were first seen at gestational day 17 and reached their maximum content at birth. SPI-containing fibers in the cornea and uvea were first observed at gestational day 17–19. The SPI-containing fibers in the iris reached their maximum content at birth, while those in the cornea, choroid and ciliary body were fully developed at postnatal day 3. In the adult rats, numerous SPI structures were still seen in the ocular tissue, retina, cornea and uvea.
These findings suggest that SPI might play some role in the developing ocular tissue in addition to its neurotransmitter or neuromodulator role in the adult, because SPI structures appear in the retina before establishment of synaptogenesis and in the cornea and uvea during the fetal stage.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6202377</pmid><doi>10.1016/0165-3806(84)90162-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain research, 1984-04, Vol.13 (2), p.275-281 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn - growth & development Biological and medical sciences Choroid - growth & development Ciliary Body - growth & development Cornea - growth & development Eye - growth & development Eye and associated structures. Visual pathways and centers. Vision Female Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology immunohistochemistry Iris - growth & development Male ocular tissue ontogeny rat Rats Retina - growth & development substance P Substance P - physiology Trigeminal Ganglion - growth & development Uvea - growth & development Vertebrates: nervous system and sense organs |
| title | Ontogeny of substance p-containing structures in the ocular tissue of the rat: An immunohistochemical analysis |
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