Evidence that forskolin binds to the glucose transporter of human erythrocytes

Binding of [4-3H]cytochalasin B and [12-3H]forskolin to human erythrocyte membranes was measured by a centrifugation method. Glucose-displaceable binding of cytochalasin B was saturable, with KD = 0.11 microM, and maximum binding approximately 550 pmol/mg of protein. Forskolin inhibited the glucose-...

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Veröffentlicht in:	The Journal of biological chemistry 1987-10, Vol.262 (30), p.14571-14575
Hauptverfasser:	Lavis, V R, Lee, D P, Shenolikar, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - analysis Adult Biological and medical sciences Cell physiology Colforsin - metabolism Cytochalasin B - metabolism erythrocytes Erythrocytes - metabolism forskolin Fundamental and applied biological sciences. Psychology glucose transporter Hexoses - pharmacology Humans In Vitro Techniques man Membrane and intracellular transports Molecular and cellular biology Monosaccharide Transport Proteins - metabolism Phlorhizin - pharmacology Protein Binding Tritium
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