Metal ion and drug binding to proteolytic fragments of calmodulin: proteolytic cadmium-113 and proton nuclear magnetic resonance studies

Tryptic fragmentation of Ca2+-saturated calmodulin (CaM) takes place mainly at Lys-77; however, proteolysis can occur instead at Arg-74 or Lys-75. This cleavage pattern results in the production of three peptides each of the amino- and carboxy-terminal halves of CaM of slightly different length. A p...

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