Iodination of monoclonal IgG antibodies at a sub-stoichiometric level: Immunoreactivity changes related to the site of iodine incorporation

Thirteen monoclonal antibodies (MAbs) were labeled with 125I to a different degree such as to cover the range from 0.5–20 μCi/μg. By SDS polyacrylamid gel electrophoresis, the amount of iodine incorporated into heavy (h) and light (l) chains was determined. Comparing different MAbs, h:l ratios varie...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1987, Vol.14 (5), p.451,455-453,457
Hauptverfasser:	Matzku, Siegfried, Kirchgeβner, Henning, Nissen, Mette
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - isolation & purification Humans Immunoglobulin G - isolation & purification Immunoglobulin Heavy Chains Immunoglobulin Light Chains Iodine Radioisotopes Kinetics Melanoma - diagnostic imaging Mice Radioisotope Dilution Technique Radionuclide Imaging Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!