Intramucosal carcinoma of the small intestine arising in regional enteritis (Crohn's Disease). Report of a case studied for carcinoembryonic antigen and review of the literature

A case of carcinoma of the small intestine arising in a patient with regional enteritis (Crohn's disease) of the ileum is reported. The patient, a 54‐year‐old woman, had a 21‐year history of regional enteritis which was treated intermittently with sulfasalazine and prednisone. Segmental resecti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer 1984-07, Vol.54 (1), p.151-162
Hauptverfasser: Perzin, Karl H., Peterson, Mark, Castiglione, Charles L., Fenoglio, Cecilia M., Wolff, Marianne
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 162
container_issue 1
container_start_page 151
container_title Cancer
container_volume 54
creator Perzin, Karl H.
Peterson, Mark
Castiglione, Charles L.
Fenoglio, Cecilia M.
Wolff, Marianne
description A case of carcinoma of the small intestine arising in a patient with regional enteritis (Crohn's disease) of the ileum is reported. The patient, a 54‐year‐old woman, had a 21‐year history of regional enteritis which was treated intermittently with sulfasalazine and prednisone. Segmental resections of the ileum had been performed on two previous occasions. Because of recurrent low‐grade intestinal obstruction, another segment of ileum was resected. The bowel demonstrated the typical gross and histologic appearance of regional enteritis. Histologic examination also disclosed a carcinoma that was confined to the ileal mucosa. This case is the first reported in which a small bowel carcinoma arising in regional enteritis has been found only in the mucosa. Adjacent to the carcinoma, the mucosa showed varying degrees of dysplasia consistent with the “precancerous” changes that have been described in inflammatory bowel disease. Using a peroxidase‐antiperoxidase immunoperoxidase technique, carcinoembryonic antigen was identified in dormal, hyperplastic, dysplastic, and carcinomatous mucosa, but the most intense staining was seen in hyperplastic and dysplastic cells. Carcinoembryonic staining, however, did not aid in differentiating between hyperplasia, dysplasia, and carcinoma because of an overlap in staining frequency and intensity.
doi_str_mv 10.1002/1097-0142(19840701)54:1<151::AID-CNCR2820540130>3.0.CO;2-4
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81059701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81059701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4950-1c0b435c89394a2d75dba198269396ad28c9ee329509f096c5c8a00b8c57bc983</originalsourceid><addsrcrecordid>eNqVkd9qFDEUxgex1LX6CEIuRNuLWZNMspOsItRp1YXiQlEQb0Imc2YbmUnWZMayj-UbmmX_gF4IXh2S7zvfOckvy94RPCUY01cEyzLHhNFzIgXDJSYXnM3JG8LJfH65uMqrT9UtFRRzhkmB3xZTPK2Wr2nOHmSTY_PDbIIxFjlnxddH2eMYv6djSXlxmp3OipJKwSfZr4Ubgu5H46PukNHBWOd7jXyLhjtAsdddh6wbIA7WAdLBRutW6QYFWFnvUhMkNdjBRnReBX_nXkZ0ZSPoCBdTdAtrH4ZtnE7pMSUOY2OhQa0Ph3HQ12HjnTVIu8GuwKXapPyfFu4Pi3Q2DdHDGOBJdtLqLsLTfT3Lvry__lx9zG-WHxbV5U1umOQ4JwbXrOBGyEIyTZuSN7VO30ln6WKmGyqMBCho8soWy5lJVo1xLQwvayNFcZa92OWug_8xpver3kYDXacd-DEqQTCXCU0yftsZTfAxBmjVOtheh40iWG15qi0StUWiDjwVZ4qoxFOpxFP9yVMVCqtqqahiKfzZfoux7qE5Ru8BJv35XtfR6K4N2hkbjzYhuGSsTDbY2e5tB5v_WvCf-_2lFL8BMOHMSw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81059701</pqid></control><display><type>article</type><title>Intramucosal carcinoma of the small intestine arising in regional enteritis (Crohn's Disease). Report of a case studied for carcinoembryonic antigen and review of the literature</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Perzin, Karl H. ; Peterson, Mark ; Castiglione, Charles L. ; Fenoglio, Cecilia M. ; Wolff, Marianne</creator><creatorcontrib>Perzin, Karl H. ; Peterson, Mark ; Castiglione, Charles L. ; Fenoglio, Cecilia M. ; Wolff, Marianne</creatorcontrib><description>A case of carcinoma of the small intestine arising in a patient with regional enteritis (Crohn's disease) of the ileum is reported. The patient, a 54‐year‐old woman, had a 21‐year history of regional enteritis which was treated intermittently with sulfasalazine and prednisone. Segmental resections of the ileum had been performed on two previous occasions. Because of recurrent low‐grade intestinal obstruction, another segment of ileum was resected. The bowel demonstrated the typical gross and histologic appearance of regional enteritis. Histologic examination also disclosed a carcinoma that was confined to the ileal mucosa. This case is the first reported in which a small bowel carcinoma arising in regional enteritis has been found only in the mucosa. Adjacent to the carcinoma, the mucosa showed varying degrees of dysplasia consistent with the “precancerous” changes that have been described in inflammatory bowel disease. Using a peroxidase‐antiperoxidase immunoperoxidase technique, carcinoembryonic antigen was identified in dormal, hyperplastic, dysplastic, and carcinomatous mucosa, but the most intense staining was seen in hyperplastic and dysplastic cells. Carcinoembryonic staining, however, did not aid in differentiating between hyperplasia, dysplasia, and carcinoma because of an overlap in staining frequency and intensity.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19840701)54:1&lt;151::AID-CNCR2820540130&gt;3.0.CO;2-4</identifier><identifier>PMID: 6372985</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Carcinoembryonic Antigen - analysis ; Carcinoma in Situ - etiology ; Carcinoma in Situ - pathology ; Crohn Disease - complications ; Crohn Disease - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Ileal Neoplasms - etiology ; Ileal Neoplasms - pathology ; Immunoenzyme Techniques ; Intestinal Mucosa - pathology ; Medical sciences ; Middle Aged ; Precancerous Conditions - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Cancer, 1984-07, Vol.54 (1), p.151-162</ispartof><rights>Copyright © 1984 American Cancer Society</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4950-1c0b435c89394a2d75dba198269396ad28c9ee329509f096c5c8a00b8c57bc983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=8859447$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6372985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perzin, Karl H.</creatorcontrib><creatorcontrib>Peterson, Mark</creatorcontrib><creatorcontrib>Castiglione, Charles L.</creatorcontrib><creatorcontrib>Fenoglio, Cecilia M.</creatorcontrib><creatorcontrib>Wolff, Marianne</creatorcontrib><title>Intramucosal carcinoma of the small intestine arising in regional enteritis (Crohn's Disease). Report of a case studied for carcinoembryonic antigen and review of the literature</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A case of carcinoma of the small intestine arising in a patient with regional enteritis (Crohn's disease) of the ileum is reported. The patient, a 54‐year‐old woman, had a 21‐year history of regional enteritis which was treated intermittently with sulfasalazine and prednisone. Segmental resections of the ileum had been performed on two previous occasions. Because of recurrent low‐grade intestinal obstruction, another segment of ileum was resected. The bowel demonstrated the typical gross and histologic appearance of regional enteritis. Histologic examination also disclosed a carcinoma that was confined to the ileal mucosa. This case is the first reported in which a small bowel carcinoma arising in regional enteritis has been found only in the mucosa. Adjacent to the carcinoma, the mucosa showed varying degrees of dysplasia consistent with the “precancerous” changes that have been described in inflammatory bowel disease. Using a peroxidase‐antiperoxidase immunoperoxidase technique, carcinoembryonic antigen was identified in dormal, hyperplastic, dysplastic, and carcinomatous mucosa, but the most intense staining was seen in hyperplastic and dysplastic cells. Carcinoembryonic staining, however, did not aid in differentiating between hyperplasia, dysplasia, and carcinoma because of an overlap in staining frequency and intensity.</description><subject>Biological and medical sciences</subject><subject>Carcinoembryonic Antigen - analysis</subject><subject>Carcinoma in Situ - etiology</subject><subject>Carcinoma in Situ - pathology</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Ileal Neoplasms - etiology</subject><subject>Ileal Neoplasms - pathology</subject><subject>Immunoenzyme Techniques</subject><subject>Intestinal Mucosa - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Precancerous Conditions - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd9qFDEUxgex1LX6CEIuRNuLWZNMspOsItRp1YXiQlEQb0Imc2YbmUnWZMayj-UbmmX_gF4IXh2S7zvfOckvy94RPCUY01cEyzLHhNFzIgXDJSYXnM3JG8LJfH65uMqrT9UtFRRzhkmB3xZTPK2Wr2nOHmSTY_PDbIIxFjlnxddH2eMYv6djSXlxmp3OipJKwSfZr4Ubgu5H46PukNHBWOd7jXyLhjtAsdddh6wbIA7WAdLBRutW6QYFWFnvUhMkNdjBRnReBX_nXkZ0ZSPoCBdTdAtrH4ZtnE7pMSUOY2OhQa0Ph3HQ12HjnTVIu8GuwKXapPyfFu4Pi3Q2DdHDGOBJdtLqLsLTfT3Lvry__lx9zG-WHxbV5U1umOQ4JwbXrOBGyEIyTZuSN7VO30ln6WKmGyqMBCho8soWy5lJVo1xLQwvayNFcZa92OWug_8xpver3kYDXacd-DEqQTCXCU0yftsZTfAxBmjVOtheh40iWG15qi0StUWiDjwVZ4qoxFOpxFP9yVMVCqtqqahiKfzZfoux7qE5Ru8BJv35XtfR6K4N2hkbjzYhuGSsTDbY2e5tB5v_WvCf-_2lFL8BMOHMSw</recordid><startdate>19840701</startdate><enddate>19840701</enddate><creator>Perzin, Karl H.</creator><creator>Peterson, Mark</creator><creator>Castiglione, Charles L.</creator><creator>Fenoglio, Cecilia M.</creator><creator>Wolff, Marianne</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840701</creationdate><title>Intramucosal carcinoma of the small intestine arising in regional enteritis (Crohn's Disease). Report of a case studied for carcinoembryonic antigen and review of the literature</title><author>Perzin, Karl H. ; Peterson, Mark ; Castiglione, Charles L. ; Fenoglio, Cecilia M. ; Wolff, Marianne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4950-1c0b435c89394a2d75dba198269396ad28c9ee329509f096c5c8a00b8c57bc983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Carcinoma in Situ - etiology</topic><topic>Carcinoma in Situ - pathology</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Ileal Neoplasms - etiology</topic><topic>Ileal Neoplasms - pathology</topic><topic>Immunoenzyme Techniques</topic><topic>Intestinal Mucosa - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Precancerous Conditions - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perzin, Karl H.</creatorcontrib><creatorcontrib>Peterson, Mark</creatorcontrib><creatorcontrib>Castiglione, Charles L.</creatorcontrib><creatorcontrib>Fenoglio, Cecilia M.</creatorcontrib><creatorcontrib>Wolff, Marianne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perzin, Karl H.</au><au>Peterson, Mark</au><au>Castiglione, Charles L.</au><au>Fenoglio, Cecilia M.</au><au>Wolff, Marianne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intramucosal carcinoma of the small intestine arising in regional enteritis (Crohn's Disease). Report of a case studied for carcinoembryonic antigen and review of the literature</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1984-07-01</date><risdate>1984</risdate><volume>54</volume><issue>1</issue><spage>151</spage><epage>162</epage><pages>151-162</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>A case of carcinoma of the small intestine arising in a patient with regional enteritis (Crohn's disease) of the ileum is reported. The patient, a 54‐year‐old woman, had a 21‐year history of regional enteritis which was treated intermittently with sulfasalazine and prednisone. Segmental resections of the ileum had been performed on two previous occasions. Because of recurrent low‐grade intestinal obstruction, another segment of ileum was resected. The bowel demonstrated the typical gross and histologic appearance of regional enteritis. Histologic examination also disclosed a carcinoma that was confined to the ileal mucosa. This case is the first reported in which a small bowel carcinoma arising in regional enteritis has been found only in the mucosa. Adjacent to the carcinoma, the mucosa showed varying degrees of dysplasia consistent with the “precancerous” changes that have been described in inflammatory bowel disease. Using a peroxidase‐antiperoxidase immunoperoxidase technique, carcinoembryonic antigen was identified in dormal, hyperplastic, dysplastic, and carcinomatous mucosa, but the most intense staining was seen in hyperplastic and dysplastic cells. Carcinoembryonic staining, however, did not aid in differentiating between hyperplasia, dysplasia, and carcinoma because of an overlap in staining frequency and intensity.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6372985</pmid><doi>10.1002/1097-0142(19840701)54:1&lt;151::AID-CNCR2820540130&gt;3.0.CO;2-4</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0008-543X
ispartof Cancer, 1984-07, Vol.54 (1), p.151-162
issn 0008-543X
1097-0142
language eng
recordid cdi_proquest_miscellaneous_81059701
source MEDLINE; Alma/SFX Local Collection
subjects Biological and medical sciences
Carcinoembryonic Antigen - analysis
Carcinoma in Situ - etiology
Carcinoma in Situ - pathology
Crohn Disease - complications
Crohn Disease - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Ileal Neoplasms - etiology
Ileal Neoplasms - pathology
Immunoenzyme Techniques
Intestinal Mucosa - pathology
Medical sciences
Middle Aged
Precancerous Conditions - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
title Intramucosal carcinoma of the small intestine arising in regional enteritis (Crohn's Disease). Report of a case studied for carcinoembryonic antigen and review of the literature
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A19%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intramucosal%20carcinoma%20of%20the%20small%20intestine%20arising%20in%20regional%20enteritis%20(Crohn's%20Disease).%20Report%20of%20a%20case%20studied%20for%20carcinoembryonic%20antigen%20and%20review%20of%20the%20literature&rft.jtitle=Cancer&rft.au=Perzin,%20Karl%20H.&rft.date=1984-07-01&rft.volume=54&rft.issue=1&rft.spage=151&rft.epage=162&rft.pages=151-162&rft.issn=0008-543X&rft.eissn=1097-0142&rft.coden=CANCAR&rft_id=info:doi/10.1002/1097-0142(19840701)54:1%3C151::AID-CNCR2820540130%3E3.0.CO;2-4&rft_dat=%3Cproquest_cross%3E81059701%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81059701&rft_id=info:pmid/6372985&rfr_iscdi=true