Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease

Enzyme histochemistry showed that a substantial number of cortical neurofibrillary tangles contain acetylcholinesterase and butyrylcholinesterase activities in patients with Alzheimer's disease and in nondemented aged individuals. In some areas of the brain, tangles containing each of these two...

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Veröffentlicht in:	Annals of neurology 1987-08, Vol.22 (2), p.223-228
Hauptverfasser:	Mesulam, M-Marsel, Asuncion Morán, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - metabolism Alzheimer Disease - enzymology Alzheimer Disease - pathology Biological and medical sciences Brain - enzymology Cholinesterases - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Male Medical sciences Neurofibrils - enzymology Neurofibrils - pathology Neurology
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Beschreibung
Zusammenfassung:	Enzyme histochemistry showed that a substantial number of cortical neurofibrillary tangles contain acetylcholinesterase and butyrylcholinesterase activities in patients with Alzheimer's disease and in nondemented aged individuals. In some areas of the brain, tangles containing each of these two enzymes were differentially distributed. In other areas, there was a very close overlap between the two types of cholinesterase.
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.410220206