Fidelity of the eukaryotic codon-anticodon interaction: interference by aminoglycoside antibiotics

A homologous in vitro method was developed from Tetrahymena for ribosomal A-site binding of aminoacyl-tRNA to poly(uridylic acid)-programmed ribosomes with very low error frequency. The reaction mixture pH was the crucial factor in the stable A-site association of aminoacyl-tRNA with high fidelity....

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Veröffentlicht in:	Biochemistry (Easton) 1984-03, Vol.23 (7), p.1462-1467
Hauptverfasser:	Eustice, David C, Wilhelm, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anticodon Binding Sites Biological and medical sciences Codon Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Molecular and cellular biology Molecular genetics Peptide Elongation Factors - metabolism Protein Biosynthesis - drug effects Replication Ribosomes - metabolism Structure-Activity Relationship Tetracycline - pharmacology Tetrahymena Tetrahymena thermophila Transfer RNA Aminoacylation
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