Parathyroid hormone and calcium metabolism in generalized scleroderma. Increased PTH level and secondary hyperparathyroidism in patients with aberrant calcifications. Prophylactic treatment of calcinosis
Parathyroid hormone (PTH) in serum and biochemical parameters of calcium metabolism were analysed in 45 patients with systemic sclerosis. Calcification of the skin and subcutaneous tissue was assessed by X-ray examination of the hands. Analyses disclosed secondary hyperparathyroidism (increased PTH...
Gespeichert in:
| Veröffentlicht in: | Archives of Dermatological Research 1984-01, Vol.276 (2), p.91-95 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 95 |
|---|---|
| container_issue | 2 |
| container_start_page | 91 |
| container_title | Archives of Dermatological Research |
| container_volume | 276 |
| creator | Serup, J Hagdrup, H K |
| description | Parathyroid hormone (PTH) in serum and biochemical parameters of calcium metabolism were analysed in 45 patients with systemic sclerosis. Calcification of the skin and subcutaneous tissue was assessed by X-ray examination of the hands. Analyses disclosed secondary hyperparathyroidism (increased PTH in serum, low calcium 'ion' in serum, decreased urinary excretion of calcium and phosphate), in particular in patients with calcinosis (P less than 0.05) as compared to those with no calcinosis. The duration of systemic sclerosis was longer in patients with calcinosis (P less than 0.05). The calcinosis type of systemic sclerosis is characterized by secondary hyperparathyroidism developed during the progression of the disease. A hypothesis is made regarding calcium metabolism in the early no-calcinosis (with increased synthesis of Vitamin D) and late calcinosis types. PTH may stimulate aberrant calcification. The hypothesis implicates that prophylactic treatment with Vitamin D in low dose may prevent calcinosis. |
| doi_str_mv | 10.1007/BF00511062 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81052160</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81052160</sourcerecordid><originalsourceid>FETCH-LOGICAL-c241t-fcc0015b45c163940f253d072ca9e382ca2e24a76efb3add652ce71fadbd32cb3</originalsourceid><addsrcrecordid>eNpFkUFr3DAQhUVpSZc0l94LOvVQ8HYk2XL22IakCQSyhxR6M2NpXKvIkitpWzZ_MX-qTnZp5jIw8817MI-x9wLWAqD9_PUKoBECtHzFVqJWsgK9-fGarUDVUCm90W_ZWc6_YKkWagntCTvRrRRNq1fscYsJy7hP0Vk-xjTFQByD5Qa9cbuJT1Swj97libvAf1KghN49kOXZeErRUppwzW-CSYR5GW_vr7mnP-SfZTKZGCymPR_3M6X5xe2oOGNxFErmf10ZOfaUEoZysB-cWbYx5DXfpjiPe4-mOMPLYlWm5YrH4UCGmF1-x94M6DOdHfsp-351eX9xXd3efbu5-HJbGVmLUg3GAIimrxsjtNrUMMhGWWilwQ2p86VJkjW2moZeobW6kYZaMaDtrZKmV6fs40F3TvH3jnLpJpcNeY-B4i535wIaKTQs4KcDaFLMOdHQzclNyzM6Ad1TeN1LeAv84ai66yey_9FjVOoflYSa8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81052160</pqid></control><display><type>article</type><title>Parathyroid hormone and calcium metabolism in generalized scleroderma. Increased PTH level and secondary hyperparathyroidism in patients with aberrant calcifications. Prophylactic treatment of calcinosis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Serup, J ; Hagdrup, H K</creator><creatorcontrib>Serup, J ; Hagdrup, H K</creatorcontrib><description>Parathyroid hormone (PTH) in serum and biochemical parameters of calcium metabolism were analysed in 45 patients with systemic sclerosis. Calcification of the skin and subcutaneous tissue was assessed by X-ray examination of the hands. Analyses disclosed secondary hyperparathyroidism (increased PTH in serum, low calcium 'ion' in serum, decreased urinary excretion of calcium and phosphate), in particular in patients with calcinosis (P less than 0.05) as compared to those with no calcinosis. The duration of systemic sclerosis was longer in patients with calcinosis (P less than 0.05). The calcinosis type of systemic sclerosis is characterized by secondary hyperparathyroidism developed during the progression of the disease. A hypothesis is made regarding calcium metabolism in the early no-calcinosis (with increased synthesis of Vitamin D) and late calcinosis types. PTH may stimulate aberrant calcification. The hypothesis implicates that prophylactic treatment with Vitamin D in low dose may prevent calcinosis.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/BF00511062</identifier><identifier>PMID: 6721576</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Calcinosis - blood ; Calcinosis - prevention & control ; Calcium - blood ; Female ; Humans ; Hydroxycholecalciferols - therapeutic use ; Hyperparathyroidism, Secondary - blood ; Male ; Middle Aged ; Parathyroid Hormone - blood ; Phosphates - blood ; Scleroderma, Systemic - blood</subject><ispartof>Archives of Dermatological Research, 1984-01, Vol.276 (2), p.91-95</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-fcc0015b45c163940f253d072ca9e382ca2e24a76efb3add652ce71fadbd32cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6721576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serup, J</creatorcontrib><creatorcontrib>Hagdrup, H K</creatorcontrib><title>Parathyroid hormone and calcium metabolism in generalized scleroderma. Increased PTH level and secondary hyperparathyroidism in patients with aberrant calcifications. Prophylactic treatment of calcinosis</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><description>Parathyroid hormone (PTH) in serum and biochemical parameters of calcium metabolism were analysed in 45 patients with systemic sclerosis. Calcification of the skin and subcutaneous tissue was assessed by X-ray examination of the hands. Analyses disclosed secondary hyperparathyroidism (increased PTH in serum, low calcium 'ion' in serum, decreased urinary excretion of calcium and phosphate), in particular in patients with calcinosis (P less than 0.05) as compared to those with no calcinosis. The duration of systemic sclerosis was longer in patients with calcinosis (P less than 0.05). The calcinosis type of systemic sclerosis is characterized by secondary hyperparathyroidism developed during the progression of the disease. A hypothesis is made regarding calcium metabolism in the early no-calcinosis (with increased synthesis of Vitamin D) and late calcinosis types. PTH may stimulate aberrant calcification. The hypothesis implicates that prophylactic treatment with Vitamin D in low dose may prevent calcinosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Calcinosis - blood</subject><subject>Calcinosis - prevention & control</subject><subject>Calcium - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxycholecalciferols - therapeutic use</subject><subject>Hyperparathyroidism, Secondary - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parathyroid Hormone - blood</subject><subject>Phosphates - blood</subject><subject>Scleroderma, Systemic - blood</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFr3DAQhUVpSZc0l94LOvVQ8HYk2XL22IakCQSyhxR6M2NpXKvIkitpWzZ_MX-qTnZp5jIw8817MI-x9wLWAqD9_PUKoBECtHzFVqJWsgK9-fGarUDVUCm90W_ZWc6_YKkWagntCTvRrRRNq1fscYsJy7hP0Vk-xjTFQByD5Qa9cbuJT1Swj97libvAf1KghN49kOXZeErRUppwzW-CSYR5GW_vr7mnP-SfZTKZGCymPR_3M6X5xe2oOGNxFErmf10ZOfaUEoZysB-cWbYx5DXfpjiPe4-mOMPLYlWm5YrH4UCGmF1-x94M6DOdHfsp-351eX9xXd3efbu5-HJbGVmLUg3GAIimrxsjtNrUMMhGWWilwQ2p86VJkjW2moZeobW6kYZaMaDtrZKmV6fs40F3TvH3jnLpJpcNeY-B4i535wIaKTQs4KcDaFLMOdHQzclNyzM6Ad1TeN1LeAv84ai66yey_9FjVOoflYSa8Q</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Serup, J</creator><creator>Hagdrup, H K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Parathyroid hormone and calcium metabolism in generalized scleroderma. Increased PTH level and secondary hyperparathyroidism in patients with aberrant calcifications. Prophylactic treatment of calcinosis</title><author>Serup, J ; Hagdrup, H K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-fcc0015b45c163940f253d072ca9e382ca2e24a76efb3add652ce71fadbd32cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Calcinosis - blood</topic><topic>Calcinosis - prevention & control</topic><topic>Calcium - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxycholecalciferols - therapeutic use</topic><topic>Hyperparathyroidism, Secondary - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parathyroid Hormone - blood</topic><topic>Phosphates - blood</topic><topic>Scleroderma, Systemic - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serup, J</creatorcontrib><creatorcontrib>Hagdrup, H K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serup, J</au><au>Hagdrup, H K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parathyroid hormone and calcium metabolism in generalized scleroderma. Increased PTH level and secondary hyperparathyroidism in patients with aberrant calcifications. Prophylactic treatment of calcinosis</atitle><jtitle>Archives of Dermatological Research</jtitle><addtitle>Arch Dermatol Res</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>276</volume><issue>2</issue><spage>91</spage><epage>95</epage><pages>91-95</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Parathyroid hormone (PTH) in serum and biochemical parameters of calcium metabolism were analysed in 45 patients with systemic sclerosis. Calcification of the skin and subcutaneous tissue was assessed by X-ray examination of the hands. Analyses disclosed secondary hyperparathyroidism (increased PTH in serum, low calcium 'ion' in serum, decreased urinary excretion of calcium and phosphate), in particular in patients with calcinosis (P less than 0.05) as compared to those with no calcinosis. The duration of systemic sclerosis was longer in patients with calcinosis (P less than 0.05). The calcinosis type of systemic sclerosis is characterized by secondary hyperparathyroidism developed during the progression of the disease. A hypothesis is made regarding calcium metabolism in the early no-calcinosis (with increased synthesis of Vitamin D) and late calcinosis types. PTH may stimulate aberrant calcification. The hypothesis implicates that prophylactic treatment with Vitamin D in low dose may prevent calcinosis.</abstract><cop>Germany</cop><pmid>6721576</pmid><doi>10.1007/BF00511062</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-3696 |
| ispartof | Archives of Dermatological Research, 1984-01, Vol.276 (2), p.91-95 |
| issn | 0340-3696 1432-069X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81052160 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Calcinosis - blood Calcinosis - prevention & control Calcium - blood Female Humans Hydroxycholecalciferols - therapeutic use Hyperparathyroidism, Secondary - blood Male Middle Aged Parathyroid Hormone - blood Phosphates - blood Scleroderma, Systemic - blood |
| title | Parathyroid hormone and calcium metabolism in generalized scleroderma. Increased PTH level and secondary hyperparathyroidism in patients with aberrant calcifications. Prophylactic treatment of calcinosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T19%3A30%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parathyroid%20hormone%20and%20calcium%20metabolism%20in%20generalized%20scleroderma.%20Increased%20PTH%20level%20and%20secondary%20hyperparathyroidism%20in%20patients%20with%20aberrant%20calcifications.%20Prophylactic%20treatment%20of%20calcinosis&rft.jtitle=Archives%20of%20Dermatological%20Research&rft.au=Serup,%20J&rft.date=1984-01-01&rft.volume=276&rft.issue=2&rft.spage=91&rft.epage=95&rft.pages=91-95&rft.issn=0340-3696&rft.eissn=1432-069X&rft_id=info:doi/10.1007/BF00511062&rft_dat=%3Cproquest_cross%3E81052160%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81052160&rft_id=info:pmid/6721576&rfr_iscdi=true |