Gastrointestinal Absorption of Americium-241 by Orally Exposed Swine: Comparison of Experimental Results with Predictions of Metabolic Models

Two groups of 11-week-old swine (40 miniature and 40 domestic swine) received a single oral administration of 1.9× 108 Bq (5.2 mCi) of 241 Am citrate, and groups of eight animals, four of each type, were killed and sampled at 1, 2, 4, 8, 16, 24, 48, 72, and 96 h and 30 days later. Uptake and excreti...

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Veröffentlicht in:	Radiat. Res.; (United States) 1987-10, Vol.112 (1), p.62-73
Hauptverfasser:	Eisele, G. R., Bernard, S. R., Nestor, C. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells ABSORPTION ACTINIDE ISOTOPES ACTINIDE NUCLEI Administration, Oral ALPHA DECAY RADIOISOTOPES Americium Americium - administration & dosage Americium - metabolism AMERICIUM 241 AMERICIUM ISOTOPES ANIMALS Biological and medical sciences BIOLOGICAL MODELS BODY Bones COMPARATIVE EVALUATIONS Computerized, statistical medical data processing and models in biomedicine DISTRIBUTION DOMESTIC ANIMALS Excretion Female Gastrointestinal tract HEAVY NUCLEI INTESTINAL ABSORPTION ISOTOPES Liver Male MAMMALS Medical sciences METABOLISM Modeling Models and simulation Models, Biological NUCLEI ODD-EVEN NUCLEI ORAL ADMINISTRATION ORGANS Plutonium RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIONUCLIDE KINETICS Rats SKELETON Space life sciences SWINE TISSUE DISTRIBUTION UPTAKE VERTEBRATES YEARS LIVING RADIOISOTOPES
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