Gastrointestinal Absorption of Americium-241 by Orally Exposed Swine: Comparison of Experimental Results with Predictions of Metabolic Models
Two groups of 11-week-old swine (40 miniature and 40 domestic swine) received a single oral administration of 1.9× 108 Bq (5.2 mCi) of 241 Am citrate, and groups of eight animals, four of each type, were killed and sampled at 1, 2, 4, 8, 16, 24, 48, 72, and 96 h and 30 days later. Uptake and excreti...
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| Veröffentlicht in: | Radiat. Res.; (United States) 1987-10, Vol.112 (1), p.62-73 |
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| creator | Eisele, G. R. Bernard, S. R. Nestor, C. W. |
| description | Two groups of 11-week-old swine (40 miniature and 40 domestic swine) received a single oral administration of 1.9× 108 Bq (5.2 mCi) of 241 Am citrate, and groups of eight animals, four of each type, were killed and sampled at 1, 2, 4, 8, 16, 24, 48, 72, and 96 h and 30 days later. Uptake and excretion patterns of the radioactivity appeared to occur in three phases: rapid uptake, rapid excretion, and then a slower excretion. All animals were systematically dissected, and the eviscerated carcasses were autoclaved for separation of bone and muscle. The predominant site of deposition was bone, and autoclaving had little effect on releasing 241 Am from either bone or muscle. The maximum fractional gastrointestinal absorption of $1.1\times 10^{-3}$ occurred 8 h after radionuclide administration. The tissue distribution data suggest partitions of 50, 20, and 30%, for bone, liver, and other soft tissues, respectively. Two metabolic models were evaluated: a modified Mewhinney-Griffith model and the ICRP 30 model to compare the biological data with model predictions. All models underestimated the actual early time data, but the fits to the experimental results were better at later times. |
| doi_str_mv | 10.2307/3577077 |
| format | Article |
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R. ; Bernard, S. R. ; Nestor, C. W.</creator><creatorcontrib>Eisele, G. R. ; Bernard, S. R. ; Nestor, C. W. ; Oak Ridge Associated Universities, TN</creatorcontrib><description>Two groups of 11-week-old swine (40 miniature and 40 domestic swine) received a single oral administration of 1.9× 108 Bq (5.2 mCi) of 241 Am citrate, and groups of eight animals, four of each type, were killed and sampled at 1, 2, 4, 8, 16, 24, 48, 72, and 96 h and 30 days later. Uptake and excretion patterns of the radioactivity appeared to occur in three phases: rapid uptake, rapid excretion, and then a slower excretion. All animals were systematically dissected, and the eviscerated carcasses were autoclaved for separation of bone and muscle. The predominant site of deposition was bone, and autoclaving had little effect on releasing 241 Am from either bone or muscle. The maximum fractional gastrointestinal absorption of $1.1\times 10^{-3}$ occurred 8 h after radionuclide administration. The tissue distribution data suggest partitions of 50, 20, and 30%, for bone, liver, and other soft tissues, respectively. Two metabolic models were evaluated: a modified Mewhinney-Griffith model and the ICRP 30 model to compare the biological data with model predictions. All models underestimated the actual early time data, but the fits to the experimental results were better at later times.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3577077</identifier><identifier>PMID: 3659299</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Academic Press, Inc</publisher><subject>560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells ; ABSORPTION ; ACTINIDE ISOTOPES ; ACTINIDE NUCLEI ; Administration, Oral ; ALPHA DECAY RADIOISOTOPES ; Americium ; Americium - administration & dosage ; Americium - metabolism ; AMERICIUM 241 ; AMERICIUM ISOTOPES ; ANIMALS ; Biological and medical sciences ; BIOLOGICAL MODELS ; BODY ; Bones ; COMPARATIVE EVALUATIONS ; Computerized, statistical medical data processing and models in biomedicine ; DISTRIBUTION ; DOMESTIC ANIMALS ; Excretion ; Female ; Gastrointestinal tract ; HEAVY NUCLEI ; INTESTINAL ABSORPTION ; ISOTOPES ; Liver ; Male ; MAMMALS ; Medical sciences ; METABOLISM ; Modeling ; Models and simulation ; Models, Biological ; NUCLEI ; ODD-EVEN NUCLEI ; ORAL ADMINISTRATION ; ORGANS ; Plutonium ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOISOTOPES ; RADIONUCLIDE KINETICS ; Rats ; SKELETON ; Space life sciences ; SWINE ; TISSUE DISTRIBUTION ; UPTAKE ; VERTEBRATES ; YEARS LIVING RADIOISOTOPES</subject><ispartof>Radiat. 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R.</creatorcontrib><creatorcontrib>Bernard, S. R.</creatorcontrib><creatorcontrib>Nestor, C. W.</creatorcontrib><creatorcontrib>Oak Ridge Associated Universities, TN</creatorcontrib><title>Gastrointestinal Absorption of Americium-241 by Orally Exposed Swine: Comparison of Experimental Results with Predictions of Metabolic Models</title><title>Radiat. Res.; (United States)</title><addtitle>Radiat Res</addtitle><description>Two groups of 11-week-old swine (40 miniature and 40 domestic swine) received a single oral administration of 1.9× 108 Bq (5.2 mCi) of 241 Am citrate, and groups of eight animals, four of each type, were killed and sampled at 1, 2, 4, 8, 16, 24, 48, 72, and 96 h and 30 days later. Uptake and excretion patterns of the radioactivity appeared to occur in three phases: rapid uptake, rapid excretion, and then a slower excretion. All animals were systematically dissected, and the eviscerated carcasses were autoclaved for separation of bone and muscle. The predominant site of deposition was bone, and autoclaving had little effect on releasing 241 Am from either bone or muscle. The maximum fractional gastrointestinal absorption of $1.1\times 10^{-3}$ occurred 8 h after radionuclide administration. The tissue distribution data suggest partitions of 50, 20, and 30%, for bone, liver, and other soft tissues, respectively. Two metabolic models were evaluated: a modified Mewhinney-Griffith model and the ICRP 30 model to compare the biological data with model predictions. All models underestimated the actual early time data, but the fits to the experimental results were better at later times.</description><subject>560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells</subject><subject>ABSORPTION</subject><subject>ACTINIDE ISOTOPES</subject><subject>ACTINIDE NUCLEI</subject><subject>Administration, Oral</subject><subject>ALPHA DECAY RADIOISOTOPES</subject><subject>Americium</subject><subject>Americium - administration & dosage</subject><subject>Americium - metabolism</subject><subject>AMERICIUM 241</subject><subject>AMERICIUM ISOTOPES</subject><subject>ANIMALS</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MODELS</subject><subject>BODY</subject><subject>Bones</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>Computerized, statistical medical data processing and models in biomedicine</subject><subject>DISTRIBUTION</subject><subject>DOMESTIC ANIMALS</subject><subject>Excretion</subject><subject>Female</subject><subject>Gastrointestinal tract</subject><subject>HEAVY NUCLEI</subject><subject>INTESTINAL ABSORPTION</subject><subject>ISOTOPES</subject><subject>Liver</subject><subject>Male</subject><subject>MAMMALS</subject><subject>Medical sciences</subject><subject>METABOLISM</subject><subject>Modeling</subject><subject>Models and simulation</subject><subject>Models, Biological</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORAL ADMINISTRATION</subject><subject>ORGANS</subject><subject>Plutonium</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOISOTOPES</subject><subject>RADIONUCLIDE KINETICS</subject><subject>Rats</subject><subject>SKELETON</subject><subject>Space life sciences</subject><subject>SWINE</subject><subject>TISSUE DISTRIBUTION</subject><subject>UPTAKE</subject><subject>VERTEBRATES</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV-L1DAUxYMo67iKn0AIIvpUTZqkaXwbhnUVdlnxz3NJ01s2S9qMuSnrfAi_sxmmrE8-hXB-9-SeHEJecva-Fkx_EEprpvUjsuFGtJWSTD4mG8aEqLRq9VPyDPGOlTtvzBk5E40ytTEb8ufSYk7Rzxkw-9kGuu0xpn32caZxpNsJknd-mapactof6E2yIRzoxe99RBjo93s_w0e6i9PeJo-noSKWqQnmXPy-AS4hI733-ZZ-TTB4dzTHI3gN2fYxeEev4wABn5Mnow0IL9bznPz8dPFj97m6urn8stteVa5mram4kWPDBj6afuROON2CFKIXwwiCD8700Pat1KbRGriyzOgaJLPAS_xRGynOyeuTbyyhO3Q-g7t1cZ7B5U61UkmlCvT2BO1T_LWU7-kmjw5CsDPEBbuWM8V5cwTfnUCXImKCsduX9DYdOs66Yzvd2k4hX62WSz_B8MCtdRT9zapbdDaMyc7O4wOmy1aCNf-wO8wx_fe1v1e2ojY</recordid><startdate>198710</startdate><enddate>198710</enddate><creator>Eisele, G. R.</creator><creator>Bernard, S. R.</creator><creator>Nestor, C. W.</creator><general>Academic Press, Inc</general><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198710</creationdate><title>Gastrointestinal Absorption of Americium-241 by Orally Exposed Swine: Comparison of Experimental Results with Predictions of Metabolic Models</title><author>Eisele, G. R. ; Bernard, S. R. ; Nestor, C. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2089-194f60d1f9bf1c3c78e433b3dfe31dc9be8b8479677e15a0972e40ae1031f7943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells</topic><topic>ABSORPTION</topic><topic>ACTINIDE ISOTOPES</topic><topic>ACTINIDE NUCLEI</topic><topic>Administration, Oral</topic><topic>ALPHA DECAY RADIOISOTOPES</topic><topic>Americium</topic><topic>Americium - administration & dosage</topic><topic>Americium - metabolism</topic><topic>AMERICIUM 241</topic><topic>AMERICIUM ISOTOPES</topic><topic>ANIMALS</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MODELS</topic><topic>BODY</topic><topic>Bones</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>Computerized, statistical medical data processing and models in biomedicine</topic><topic>DISTRIBUTION</topic><topic>DOMESTIC ANIMALS</topic><topic>Excretion</topic><topic>Female</topic><topic>Gastrointestinal tract</topic><topic>HEAVY NUCLEI</topic><topic>INTESTINAL ABSORPTION</topic><topic>ISOTOPES</topic><topic>Liver</topic><topic>Male</topic><topic>MAMMALS</topic><topic>Medical sciences</topic><topic>METABOLISM</topic><topic>Modeling</topic><topic>Models and simulation</topic><topic>Models, Biological</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORAL ADMINISTRATION</topic><topic>ORGANS</topic><topic>Plutonium</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOISOTOPES</topic><topic>RADIONUCLIDE KINETICS</topic><topic>Rats</topic><topic>SKELETON</topic><topic>Space life sciences</topic><topic>SWINE</topic><topic>TISSUE DISTRIBUTION</topic><topic>UPTAKE</topic><topic>VERTEBRATES</topic><topic>YEARS LIVING RADIOISOTOPES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eisele, G. R.</creatorcontrib><creatorcontrib>Bernard, S. R.</creatorcontrib><creatorcontrib>Nestor, C. W.</creatorcontrib><creatorcontrib>Oak Ridge Associated Universities, TN</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Radiat. Res.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eisele, G. R.</au><au>Bernard, S. R.</au><au>Nestor, C. W.</au><aucorp>Oak Ridge Associated Universities, TN</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrointestinal Absorption of Americium-241 by Orally Exposed Swine: Comparison of Experimental Results with Predictions of Metabolic Models</atitle><jtitle>Radiat. Res.; (United States)</jtitle><addtitle>Radiat Res</addtitle><date>1987-10</date><risdate>1987</risdate><volume>112</volume><issue>1</issue><spage>62</spage><epage>73</epage><pages>62-73</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>Two groups of 11-week-old swine (40 miniature and 40 domestic swine) received a single oral administration of 1.9× 108 Bq (5.2 mCi) of 241 Am citrate, and groups of eight animals, four of each type, were killed and sampled at 1, 2, 4, 8, 16, 24, 48, 72, and 96 h and 30 days later. Uptake and excretion patterns of the radioactivity appeared to occur in three phases: rapid uptake, rapid excretion, and then a slower excretion. All animals were systematically dissected, and the eviscerated carcasses were autoclaved for separation of bone and muscle. The predominant site of deposition was bone, and autoclaving had little effect on releasing 241 Am from either bone or muscle. The maximum fractional gastrointestinal absorption of $1.1\times 10^{-3}$ occurred 8 h after radionuclide administration. The tissue distribution data suggest partitions of 50, 20, and 30%, for bone, liver, and other soft tissues, respectively. Two metabolic models were evaluated: a modified Mewhinney-Griffith model and the ICRP 30 model to compare the biological data with model predictions. All models underestimated the actual early time data, but the fits to the experimental results were better at later times.</abstract><cop>Oak Brook, Il</cop><pub>Academic Press, Inc</pub><pmid>3659299</pmid><doi>10.2307/3577077</doi><tpages>12</tpages></addata></record> |
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| ispartof | Radiat. Res.; (United States), 1987-10, Vol.112 (1), p.62-73 |
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| language | eng |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | 560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells ABSORPTION ACTINIDE ISOTOPES ACTINIDE NUCLEI Administration, Oral ALPHA DECAY RADIOISOTOPES Americium Americium - administration & dosage Americium - metabolism AMERICIUM 241 AMERICIUM ISOTOPES ANIMALS Biological and medical sciences BIOLOGICAL MODELS BODY Bones COMPARATIVE EVALUATIONS Computerized, statistical medical data processing and models in biomedicine DISTRIBUTION DOMESTIC ANIMALS Excretion Female Gastrointestinal tract HEAVY NUCLEI INTESTINAL ABSORPTION ISOTOPES Liver Male MAMMALS Medical sciences METABOLISM Modeling Models and simulation Models, Biological NUCLEI ODD-EVEN NUCLEI ORAL ADMINISTRATION ORGANS Plutonium RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIONUCLIDE KINETICS Rats SKELETON Space life sciences SWINE TISSUE DISTRIBUTION UPTAKE VERTEBRATES YEARS LIVING RADIOISOTOPES |
| title | Gastrointestinal Absorption of Americium-241 by Orally Exposed Swine: Comparison of Experimental Results with Predictions of Metabolic Models |
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