Transformation by Oncogenes Encoding Protein Kinases Induces the Metastatic Phenotype

Oncogenes encoding serine/threonine or tyrosine kinases were introduced into the established rodent fibroblast cell line NIH 3T3 and tested for tumorigenic and metastatic behavior in T cell-deficient nude mice. Transforming oncogenes of the ras family were capable of converting fibroblast cell lines...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1987-10, Vol.238 (4824), p.202-205
Hauptverfasser:	Egan, Sean E., Wright, Jim A., Jarolim, Lenka, Yanagihara, Kazuyoshi, Bassin, Robert H., Greenberg, Arnold H.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Animals Biochemistry Cancer Cancer metastasis Carcinogenesis Cell lines Cell Transformation, Neoplastic Cells, Cultured Enzymes Genes Genetic aspects Genetics Infections Lungs Medical research Metastasis Mice Neoplasm Metastasis NIH 3T3 cells Oncogenes Phenotype Protein Kinases - genetics Proteins Rodents Transformed cell line Tumor cell line Tumors
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