Transduction of mitogenic signals in T lymphocytes: role of inositol phospholipids for the rapid activation of ornithine decarboxylase

Treatment of human T lymphocytes with mitogenic ligands, such as concanavalin A (Con A), induces a rapid activation of the enzyme ornithine decarboxylase (ODC). This activation occurs within minutes and is completely inhibited when the cells are treated with 1 mM Li+ (in an inositol-free medium) pri...

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Veröffentlicht in:	Scandinavian journal of immunology 1987-09, Vol.26 (3), p.287-294
Hauptverfasser:	MUSTELIN, T, POSO, H, STAHLS, A, ELORANTA, T, ANDERSSON, L. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Enzyme Activation Exact sciences and technology Humans Inositol - pharmacology Inositol 1,4,5-Trisphosphate Inositol Phosphates - pharmacology Lithium - pharmacology Lymphocyte Activation Ornithine Decarboxylase - analysis Other techniques and industries Phosphatidylinositols - pharmacology Putrescine - analysis T-Lymphocytes - enzymology T-Lymphocytes - immunology
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