Viral transduction of c-myc gene in naturally occurring feline leukaemias
Feline leukaemia virus (FeLV) is epidemiologically associated with induction of the majority of lymphoid tumours of the domestic cat 1 . However, about one-third of these tumours are devoid of exogenous virus or show evidence of virus integration only after tumour outgrowth 1,2 . To help define the...
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| Veröffentlicht in: | Nature (London) 1984-04, Vol.308 (5962), p.856-858 |
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| creator | Mullins, J.I Brody, D.S Binari, R.C. Jr Cotter, S.M |
| description | Feline leukaemia virus (FeLV) is epidemiologically associated with induction of the majority of lymphoid tumours of the domestic cat
1
. However, about one-third of these tumours are devoid of exogenous virus or show evidence of virus integration only after tumour outgrowth
1,2
. To help define the genetic mechanisms of feline lymphomagenesis we have explored here the possibility that cellular oncogenes (c-
onc
genes) are rearranged in tumour cell DNA. Of 16 FeLV-positive T-cell tumours among 31 naturally occurring lymphomas, 2 showed evidence of recombinant FeLV proviruses containing
myc
oncogene sequences. One of the two produced a transmissible
myc
-containing FeLV. In both cases c-
myc
and its surrounding DNA appeared unaltered. We believe that the association of
myc
with FeLV may result in its activation and play a part in the development of a significant fraction of cat T-cell lymphomas. Our findings contrast with studies of experimental induction of chicken lymphoma, in which
myc
activation occurs by retrovirus promoter insertion near c-
myc
(refs 3–5), rather than by incorporation into virus. |
| doi_str_mv | 10.1038/308856a0 |
| format | Article |
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1
. However, about one-third of these tumours are devoid of exogenous virus or show evidence of virus integration only after tumour outgrowth
1,2
. To help define the genetic mechanisms of feline lymphomagenesis we have explored here the possibility that cellular oncogenes (c-
onc
genes) are rearranged in tumour cell DNA. Of 16 FeLV-positive T-cell tumours among 31 naturally occurring lymphomas, 2 showed evidence of recombinant FeLV proviruses containing
myc
oncogene sequences. One of the two produced a transmissible
myc
-containing FeLV. In both cases c-
myc
and its surrounding DNA appeared unaltered. We believe that the association of
myc
with FeLV may result in its activation and play a part in the development of a significant fraction of cat T-cell lymphomas. Our findings contrast with studies of experimental induction of chicken lymphoma, in which
myc
activation occurs by retrovirus promoter insertion near c-
myc
(refs 3–5), rather than by incorporation into virus.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/308856a0</identifier><identifier>PMID: 6325922</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>animal diseases ; animal health ; Animal tumors. Experimental tumors ; Animals ; Base Sequence ; Biological and medical sciences ; Cat Diseases - microbiology ; Cats ; DNA Restriction Enzymes ; DNA, Neoplasm - genetics ; DNA, Viral - genetics ; Genes, Viral ; Humanities and Social Sciences ; letter ; Leukemia - microbiology ; Leukemia - veterinary ; Leukemia Virus, Feline - genetics ; Medical sciences ; multidisciplinary ; Oncogenes ; Science ; Science (multidisciplinary) ; Spontaneous animal tumors ; Transduction, Genetic ; Tumors ; viral diseases of animals and humans</subject><ispartof>Nature (London), 1984-04, Vol.308 (5962), p.856-858</ispartof><rights>Springer Nature Limited 1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3460-9d39d193c3f1323d0c00ce1d2cb12b84f1b898abdfd16930a5c004cd47c08a723</citedby><cites>FETCH-LOGICAL-c3460-9d39d193c3f1323d0c00ce1d2cb12b84f1b898abdfd16930a5c004cd47c08a723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/308856a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/308856a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8906602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6325922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mullins, J.I</creatorcontrib><creatorcontrib>Brody, D.S</creatorcontrib><creatorcontrib>Binari, R.C. Jr</creatorcontrib><creatorcontrib>Cotter, S.M</creatorcontrib><title>Viral transduction of c-myc gene in naturally occurring feline leukaemias</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Feline leukaemia virus (FeLV) is epidemiologically associated with induction of the majority of lymphoid tumours of the domestic cat
1
. However, about one-third of these tumours are devoid of exogenous virus or show evidence of virus integration only after tumour outgrowth
1,2
. To help define the genetic mechanisms of feline lymphomagenesis we have explored here the possibility that cellular oncogenes (c-
onc
genes) are rearranged in tumour cell DNA. Of 16 FeLV-positive T-cell tumours among 31 naturally occurring lymphomas, 2 showed evidence of recombinant FeLV proviruses containing
myc
oncogene sequences. One of the two produced a transmissible
myc
-containing FeLV. In both cases c-
myc
and its surrounding DNA appeared unaltered. We believe that the association of
myc
with FeLV may result in its activation and play a part in the development of a significant fraction of cat T-cell lymphomas. Our findings contrast with studies of experimental induction of chicken lymphoma, in which
myc
activation occurs by retrovirus promoter insertion near c-
myc
(refs 3–5), rather than by incorporation into virus.</description><subject>animal diseases</subject><subject>animal health</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cat Diseases - microbiology</subject><subject>Cats</subject><subject>DNA Restriction Enzymes</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Viral - genetics</subject><subject>Genes, Viral</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Leukemia - microbiology</subject><subject>Leukemia - veterinary</subject><subject>Leukemia Virus, Feline - genetics</subject><subject>Medical sciences</subject><subject>multidisciplinary</subject><subject>Oncogenes</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Spontaneous animal tumors</subject><subject>Transduction, Genetic</subject><subject>Tumors</subject><subject>viral diseases of animals and humans</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0EtLAzEUhuEgitYL-AfEWYjoYvQkJ5PJLKV4g4ILL9shk0uJzqUmnUX_vSmtrlxlcR6-wEvIKYUbCihvEaQshIIdMqG8FDkXstwlEwAmc5AoDshhjJ8AUNCS75N9gayoGJuQ5w8fVJstg-qjGfXSD302uEzn3Upnc9vbzPdZr5ZjUu0qG7QeQ_D9PHO29ena2vFL2c6reEz2nGqjPdm-R-T94f5t-pTPXh6fp3ezXCMXkFcGK0Mr1OgoMjSgAbSlhumGskZyRxtZSdUYZ6ioEFSRANeGlxqkKhkekcvN7iIM36ONy7rzUdu2Vb0dxlhLCrwoEBO82kAdhhiDdfUi-E6FVU2hXlerf6slerbdHJvOmj-4zZTuF9u7ilq1LtXSPv4xWYEQsGbXGxYX60Y21J_DGPpU478vzzfWqaFW85Dm3l8ZUARWoOQVxR82NIl0</recordid><startdate>19840426</startdate><enddate>19840426</enddate><creator>Mullins, J.I</creator><creator>Brody, D.S</creator><creator>Binari, R.C. Jr</creator><creator>Cotter, S.M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840426</creationdate><title>Viral transduction of c-myc gene in naturally occurring feline leukaemias</title><author>Mullins, J.I ; Brody, D.S ; Binari, R.C. Jr ; Cotter, S.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3460-9d39d193c3f1323d0c00ce1d2cb12b84f1b898abdfd16930a5c004cd47c08a723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>animal diseases</topic><topic>animal health</topic><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cat Diseases - microbiology</topic><topic>Cats</topic><topic>DNA Restriction Enzymes</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Viral - genetics</topic><topic>Genes, Viral</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Leukemia - microbiology</topic><topic>Leukemia - veterinary</topic><topic>Leukemia Virus, Feline - genetics</topic><topic>Medical sciences</topic><topic>multidisciplinary</topic><topic>Oncogenes</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Spontaneous animal tumors</topic><topic>Transduction, Genetic</topic><topic>Tumors</topic><topic>viral diseases of animals and humans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mullins, J.I</creatorcontrib><creatorcontrib>Brody, D.S</creatorcontrib><creatorcontrib>Binari, R.C. Jr</creatorcontrib><creatorcontrib>Cotter, S.M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mullins, J.I</au><au>Brody, D.S</au><au>Binari, R.C. Jr</au><au>Cotter, S.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Viral transduction of c-myc gene in naturally occurring feline leukaemias</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1984-04-26</date><risdate>1984</risdate><volume>308</volume><issue>5962</issue><spage>856</spage><epage>858</epage><pages>856-858</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Feline leukaemia virus (FeLV) is epidemiologically associated with induction of the majority of lymphoid tumours of the domestic cat
1
. However, about one-third of these tumours are devoid of exogenous virus or show evidence of virus integration only after tumour outgrowth
1,2
. To help define the genetic mechanisms of feline lymphomagenesis we have explored here the possibility that cellular oncogenes (c-
onc
genes) are rearranged in tumour cell DNA. Of 16 FeLV-positive T-cell tumours among 31 naturally occurring lymphomas, 2 showed evidence of recombinant FeLV proviruses containing
myc
oncogene sequences. One of the two produced a transmissible
myc
-containing FeLV. In both cases c-
myc
and its surrounding DNA appeared unaltered. We believe that the association of
myc
with FeLV may result in its activation and play a part in the development of a significant fraction of cat T-cell lymphomas. Our findings contrast with studies of experimental induction of chicken lymphoma, in which
myc
activation occurs by retrovirus promoter insertion near c-
myc
(refs 3–5), rather than by incorporation into virus.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6325922</pmid><doi>10.1038/308856a0</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | animal diseases animal health Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Cat Diseases - microbiology Cats DNA Restriction Enzymes DNA, Neoplasm - genetics DNA, Viral - genetics Genes, Viral Humanities and Social Sciences letter Leukemia - microbiology Leukemia - veterinary Leukemia Virus, Feline - genetics Medical sciences multidisciplinary Oncogenes Science Science (multidisciplinary) Spontaneous animal tumors Transduction, Genetic Tumors viral diseases of animals and humans |
| title | Viral transduction of c-myc gene in naturally occurring feline leukaemias |
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