The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits
NUSHIRO, N., ABE, K., SEINO, M., ITOH, S. and YOSHINAGA, K. The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits. Tohoku J. exp. Med., 1987, 152 (3), 301-310 To determine the effects of α-human atrial natriuretic peptide (ANP) on renal...
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| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1987, Vol.152(3), pp.301-310 |
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| creator | NUSHIRO, NOBORU ABE, KEISHI SEINO, MASAHIDE ITOH, SADAYOSHI YOSHINAGA, KAORU |
| description | NUSHIRO, N., ABE, K., SEINO, M., ITOH, S. and YOSHINAGA, K. The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits. Tohoku J. exp. Med., 1987, 152 (3), 301-310 To determine the effects of α-human atrial natriuretic peptide (ANP) on renal function and the renin-aldosterone system in anesthetized rabbits, ANP (0.05μg/kg/min) or 5% dextrose solution in vehicle control was infused intravenously. The infusion ofANP resulted in a significant decrease in mean arterial pressure with an increase in renal blood flow (RBF). ANP also produced significant increases in urine volume and urinary sodium excretion. ANP tended to increase glomerular filtration rate, filtered sodium load and net tubular reabsorption of sodium. However, there were no significant differences in these parameters compared with control group. Fractional sodium excretion was increased significantly by ANP. Plasma renin activity (PRA) was suppressed only at 30min after the infusion of ANP, while a significant fall in plasma aldosterone concentration (PAC) lasted even in the recovery period. These results indicate that ANP produces a diuresis and natriuresis through the increased RBF in anesthetized rabbits. It is also suggested that ANP suppresses PAC independent of the inhibition of PRA. |
| doi_str_mv | 10.1620/tjem.152.301 |
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The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits. Tohoku J. exp. Med., 1987, 152 (3), 301-310 To determine the effects of α-human atrial natriuretic peptide (ANP) on renal function and the renin-aldosterone system in anesthetized rabbits, ANP (0.05μg/kg/min) or 5% dextrose solution in vehicle control was infused intravenously. The infusion ofANP resulted in a significant decrease in mean arterial pressure with an increase in renal blood flow (RBF). ANP also produced significant increases in urine volume and urinary sodium excretion. ANP tended to increase glomerular filtration rate, filtered sodium load and net tubular reabsorption of sodium. However, there were no significant differences in these parameters compared with control group. Fractional sodium excretion was increased significantly by ANP. Plasma renin activity (PRA) was suppressed only at 30min after the infusion of ANP, while a significant fall in plasma aldosterone concentration (PAC) lasted even in the recovery period. These results indicate that ANP produces a diuresis and natriuresis through the increased RBF in anesthetized rabbits. It is also suggested that ANP suppresses PAC independent of the inhibition of PRA.</description><identifier>ISSN: 0040-8727</identifier><identifier>EISSN: 1349-3329</identifier><identifier>DOI: 10.1620/tjem.152.301</identifier><identifier>PMID: 2958960</identifier><language>eng</language><publisher>Japan: Tohoku University Medical Press</publisher><subject>Aldosterone - blood ; Animals ; Atrial Natriuretic Factor - pharmacology ; atrial natriuretic peptide ; Blood Pressure - drug effects ; Diuresis - drug effects ; Female ; Glomerular Filtration Rate - drug effects ; Kidney - blood supply ; Kidney - drug effects ; Kidney - physiology ; natriuresis ; Natriuresis - drug effects ; Rabbits ; Renal Circulation - drug effects ; renal hemodynamics ; Renin - blood ; Renin-Angiotensin System - drug effects ; renin-angiotensin-aldosterone system ; Urine ; Vascular Resistance - drug effects</subject><ispartof>The Tohoku Journal of Experimental Medicine, 1987, Vol.152(3), pp.301-310</ispartof><rights>Tohoku University Medical Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-58d07c684cdc18b8f263510b06464552357eb2aebac44e7056f08e6cbce050e53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2958960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NUSHIRO, NOBORU</creatorcontrib><creatorcontrib>ABE, KEISHI</creatorcontrib><creatorcontrib>SEINO, MASAHIDE</creatorcontrib><creatorcontrib>ITOH, SADAYOSHI</creatorcontrib><creatorcontrib>YOSHINAGA, KAORU</creatorcontrib><title>The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits</title><title>The Tohoku Journal of Experimental Medicine</title><addtitle>Tohoku J. Exp. Med.</addtitle><description>NUSHIRO, N., ABE, K., SEINO, M., ITOH, S. and YOSHINAGA, K. The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits. Tohoku J. exp. Med., 1987, 152 (3), 301-310 To determine the effects of α-human atrial natriuretic peptide (ANP) on renal function and the renin-aldosterone system in anesthetized rabbits, ANP (0.05μg/kg/min) or 5% dextrose solution in vehicle control was infused intravenously. The infusion ofANP resulted in a significant decrease in mean arterial pressure with an increase in renal blood flow (RBF). ANP also produced significant increases in urine volume and urinary sodium excretion. ANP tended to increase glomerular filtration rate, filtered sodium load and net tubular reabsorption of sodium. However, there were no significant differences in these parameters compared with control group. Fractional sodium excretion was increased significantly by ANP. Plasma renin activity (PRA) was suppressed only at 30min after the infusion of ANP, while a significant fall in plasma aldosterone concentration (PAC) lasted even in the recovery period. These results indicate that ANP produces a diuresis and natriuresis through the increased RBF in anesthetized rabbits. It is also suggested that ANP suppresses PAC independent of the inhibition of PRA.</description><subject>Aldosterone - blood</subject><subject>Animals</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>atrial natriuretic peptide</subject><subject>Blood Pressure - drug effects</subject><subject>Diuresis - drug effects</subject><subject>Female</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Kidney - blood supply</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>natriuresis</subject><subject>Natriuresis - drug effects</subject><subject>Rabbits</subject><subject>Renal Circulation - drug effects</subject><subject>renal hemodynamics</subject><subject>Renin - blood</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>renin-angiotensin-aldosterone system</subject><subject>Urine</subject><subject>Vascular Resistance - drug effects</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1v3CAURVHVKp0k3XVbiVVX9fRhPoyXoyjTRoraKEnXCOPnhpGNp4AX6a8PyYxmwwPu4QhdQj4zWDNVw_e8w2nNZL3mwN6RFeOirTiv2_dkBSCg0k3dfCTnKe0AuIBGnZGzupW6VbAi-fEJ6fUwoMuJzgPd5OjtSH_ZMpeI2Tt6h_vse6RzoPcYSrhdgsu-HG3oaS7vy7UP1Wbs55QxzgHpw3PZTdQHugmYCpP9f-zpve06n9Ml-TDYMeGn47wgf7bXj1c_q9vfP26uNreVk1LkSuoeGqe0cL1jutNDrbhk0IESSkhZc9lgV1vsrBMCG5BqAI3KdQ5BAkp-Qb4evPs4_1vKP8zkk8NxtAHnJRnNQHAAXcBvB9DFOaWIg9lHP9n4bBiY15LNa8mmlGxKyQX_cvQu3YT9CT62WvLtId-lbP_iKbex9Dnim4y1xfomPK5FfALck40GA38Bw4GRdg</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>NUSHIRO, NOBORU</creator><creator>ABE, KEISHI</creator><creator>SEINO, MASAHIDE</creator><creator>ITOH, SADAYOSHI</creator><creator>YOSHINAGA, KAORU</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits</title><author>NUSHIRO, NOBORU ; ABE, KEISHI ; SEINO, MASAHIDE ; ITOH, SADAYOSHI ; YOSHINAGA, KAORU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-58d07c684cdc18b8f263510b06464552357eb2aebac44e7056f08e6cbce050e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aldosterone - blood</topic><topic>Animals</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>atrial natriuretic peptide</topic><topic>Blood Pressure - drug effects</topic><topic>Diuresis - drug effects</topic><topic>Female</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Kidney - blood supply</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>natriuresis</topic><topic>Natriuresis - drug effects</topic><topic>Rabbits</topic><topic>Renal Circulation - drug effects</topic><topic>renal hemodynamics</topic><topic>Renin - blood</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>renin-angiotensin-aldosterone system</topic><topic>Urine</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NUSHIRO, NOBORU</creatorcontrib><creatorcontrib>ABE, KEISHI</creatorcontrib><creatorcontrib>SEINO, MASAHIDE</creatorcontrib><creatorcontrib>ITOH, SADAYOSHI</creatorcontrib><creatorcontrib>YOSHINAGA, KAORU</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NUSHIRO, NOBORU</au><au>ABE, KEISHI</au><au>SEINO, MASAHIDE</au><au>ITOH, SADAYOSHI</au><au>YOSHINAGA, KAORU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. Exp. Med.</addtitle><date>1987</date><risdate>1987</risdate><volume>152</volume><issue>3</issue><spage>301</spage><epage>310</epage><pages>301-310</pages><issn>0040-8727</issn><eissn>1349-3329</eissn><abstract>NUSHIRO, N., ABE, K., SEINO, M., ITOH, S. and YOSHINAGA, K. The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits. Tohoku J. exp. Med., 1987, 152 (3), 301-310 To determine the effects of α-human atrial natriuretic peptide (ANP) on renal function and the renin-aldosterone system in anesthetized rabbits, ANP (0.05μg/kg/min) or 5% dextrose solution in vehicle control was infused intravenously. The infusion ofANP resulted in a significant decrease in mean arterial pressure with an increase in renal blood flow (RBF). ANP also produced significant increases in urine volume and urinary sodium excretion. ANP tended to increase glomerular filtration rate, filtered sodium load and net tubular reabsorption of sodium. However, there were no significant differences in these parameters compared with control group. Fractional sodium excretion was increased significantly by ANP. Plasma renin activity (PRA) was suppressed only at 30min after the infusion of ANP, while a significant fall in plasma aldosterone concentration (PAC) lasted even in the recovery period. These results indicate that ANP produces a diuresis and natriuresis through the increased RBF in anesthetized rabbits. It is also suggested that ANP suppresses PAC independent of the inhibition of PRA.</abstract><cop>Japan</cop><pub>Tohoku University Medical Press</pub><pmid>2958960</pmid><doi>10.1620/tjem.152.301</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aldosterone - blood Animals Atrial Natriuretic Factor - pharmacology atrial natriuretic peptide Blood Pressure - drug effects Diuresis - drug effects Female Glomerular Filtration Rate - drug effects Kidney - blood supply Kidney - drug effects Kidney - physiology natriuresis Natriuresis - drug effects Rabbits Renal Circulation - drug effects renal hemodynamics Renin - blood Renin-Angiotensin System - drug effects renin-angiotensin-aldosterone system Urine Vascular Resistance - drug effects |
| title | The Effects of Atrial Natriuretic Peptide on Renal Function and the Renin-Aldosterone System in Anesthetized Rabbits |
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