Short-Chain Fatty Acids and Succinate in Feces of Healthy Human Volunteers and Their Correlation with Anaerobe Cultural Counts
Short-chain fatty acids (SCFA) and succinate in fresh feces from 10 healthy human volunteers were detected with gas-liquid chromatography and were correlated with their fecal cultural counts. The SCFA content of feces did not change significantly after freezing, but the cultural counts of total anae...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1987, Vol.22 (6), p.672-676 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | Meijer-Severs, G. J. Van Santen, E. |
| description | Short-chain fatty acids (SCFA) and succinate in fresh feces from 10 healthy human volunteers were detected with gas-liquid chromatography and were correlated with their fecal cultural counts. The SCFA content of feces did not change significantly after freezing, but the cultural counts of total anaerobes and bifidobacteria showed significant changes (0.001 < P < 0.01). A significant negative correlation (r = -0.78; 0.01 < P < 0.02) was found between the bifidobacteria cultural counts and the succinic acid concentration in fresh feces, which disappeared after freezing of the samples. Because of the significant differences in cultural counts and the shift in significant correlations after freezing, it is important to use fresh fecal samples for these correlation studies. Lactic acid and i-caproic acid were not found in the fecal samples. The results show that SCFA and organic acid concentrations cannot replace (an)aerobe cultural counts in fecal flora studies of healthy human volunteers because of the low rate of significant correlations between these two. |
| doi_str_mv | 10.3109/00365528709011141 |
| format | Article |
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J. ; Van Santen, E.</creator><creatorcontrib>Meijer-Severs, G. J. ; Van Santen, E.</creatorcontrib><description>Short-chain fatty acids (SCFA) and succinate in fresh feces from 10 healthy human volunteers were detected with gas-liquid chromatography and were correlated with their fecal cultural counts. The SCFA content of feces did not change significantly after freezing, but the cultural counts of total anaerobes and bifidobacteria showed significant changes (0.001 < P < 0.01). A significant negative correlation (r = -0.78; 0.01 < P < 0.02) was found between the bifidobacteria cultural counts and the succinic acid concentration in fresh feces, which disappeared after freezing of the samples. Because of the significant differences in cultural counts and the shift in significant correlations after freezing, it is important to use fresh fecal samples for these correlation studies. Lactic acid and i-caproic acid were not found in the fecal samples. The results show that SCFA and organic acid concentrations cannot replace (an)aerobe cultural counts in fecal flora studies of healthy human volunteers because of the low rate of significant correlations between these two.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365528709011141</identifier><identifier>PMID: 3659829</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adult ; Anaerobes ; Bacteria, Aerobic - analysis ; Bacteria, Anaerobic - analysis ; Biological and medical sciences ; Chromatography, Gas ; cultural counts ; Fatty Acids, Volatile - analysis ; Feces - analysis ; Feces - microbiology ; Fundamental and applied biological sciences. Psychology ; gas-liquid chromatography ; Humans ; Intestine. Mesentery ; Male ; Middle Aged ; short-chain fatty acids ; Specimen Handling ; succinate ; Succinates - analysis ; Vertebrates: digestive system</subject><ispartof>Scandinavian journal of gastroenterology, 1987, Vol.22 (6), p.672-676</ispartof><rights>1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-18f8132daa8aac51f8dc54ff157ed061ef39dc46dfa9e14f81286113ff54f1543</citedby><cites>FETCH-LOGICAL-c461t-18f8132daa8aac51f8dc54ff157ed061ef39dc46dfa9e14f81286113ff54f1543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365528709011141$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365528709011141$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,778,782,4012,27910,27911,27912,59632,59738,60421,60527,61206,61241,61387,61422</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7665698$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3659829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meijer-Severs, G. J.</creatorcontrib><creatorcontrib>Van Santen, E.</creatorcontrib><title>Short-Chain Fatty Acids and Succinate in Feces of Healthy Human Volunteers and Their Correlation with Anaerobe Cultural Counts</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Short-chain fatty acids (SCFA) and succinate in fresh feces from 10 healthy human volunteers were detected with gas-liquid chromatography and were correlated with their fecal cultural counts. The SCFA content of feces did not change significantly after freezing, but the cultural counts of total anaerobes and bifidobacteria showed significant changes (0.001 < P < 0.01). A significant negative correlation (r = -0.78; 0.01 < P < 0.02) was found between the bifidobacteria cultural counts and the succinic acid concentration in fresh feces, which disappeared after freezing of the samples. Because of the significant differences in cultural counts and the shift in significant correlations after freezing, it is important to use fresh fecal samples for these correlation studies. Lactic acid and i-caproic acid were not found in the fecal samples. The results show that SCFA and organic acid concentrations cannot replace (an)aerobe cultural counts in fecal flora studies of healthy human volunteers because of the low rate of significant correlations between these two.</description><subject>Adult</subject><subject>Anaerobes</subject><subject>Bacteria, Aerobic - analysis</subject><subject>Bacteria, Anaerobic - analysis</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Gas</subject><subject>cultural counts</subject><subject>Fatty Acids, Volatile - analysis</subject><subject>Feces - analysis</subject><subject>Feces - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gas-liquid chromatography</subject><subject>Humans</subject><subject>Intestine. Mesentery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>short-chain fatty acids</subject><subject>Specimen Handling</subject><subject>succinate</subject><subject>Succinates - analysis</subject><subject>Vertebrates: digestive system</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFDEYhgdR6rb6AzwIOYi30Xwzk5kMelkW2xUKHlq9Dl8zX5iUTFKTDGUv_e1m3bUgQj3l8D7PyxfeongD_EMNvP_Ied0KUcmO9xwAGnhWrEDwquw6Lp8Xq31eZgBeFqcx3nLORdf0J8VJ1npZ9avi4WryIZWbCY1j55jSjq2VGSNDN7KrRSnjMBHbh6QoMq_ZltCmace2y4yO_fB2cYkoHJTriUxgGx8CWUzGO3Zv0sTWDin4G2KbxaYloM1I1uKr4oVGG-n18T0rvp9_ud5sy8tvF18368tSNS2kEqSWUFcjokRUArQclWi0BtHRyFsgXfdjRkeNPUGT4Uq2ALXWmQLR1GfF-0PvXfA_F4ppmE1UZC068kscJPCmqvruvyA0nRQS9o1wAFXwMQbSw10wM4bdAHzYjzP8M0523h7Ll5uZxkfjuEbO3x1zjAqtDuiUiY9Y17ai7WXGPh8w47QPM977YMch4c768Mepn7ri01_69HtPhYGGW78El3d44g-_AOeivFk</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Meijer-Severs, G. J.</creator><creator>Van Santen, E.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Short-Chain Fatty Acids and Succinate in Feces of Healthy Human Volunteers and Their Correlation with Anaerobe Cultural Counts</title><author>Meijer-Severs, G. J. ; Van Santen, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-18f8132daa8aac51f8dc54ff157ed061ef39dc46dfa9e14f81286113ff54f1543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Anaerobes</topic><topic>Bacteria, Aerobic - analysis</topic><topic>Bacteria, Anaerobic - analysis</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Gas</topic><topic>cultural counts</topic><topic>Fatty Acids, Volatile - analysis</topic><topic>Feces - analysis</topic><topic>Feces - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gas-liquid chromatography</topic><topic>Humans</topic><topic>Intestine. Mesentery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>short-chain fatty acids</topic><topic>Specimen Handling</topic><topic>succinate</topic><topic>Succinates - analysis</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meijer-Severs, G. J.</creatorcontrib><creatorcontrib>Van Santen, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meijer-Severs, G. J.</au><au>Van Santen, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-Chain Fatty Acids and Succinate in Feces of Healthy Human Volunteers and Their Correlation with Anaerobe Cultural Counts</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1987</date><risdate>1987</risdate><volume>22</volume><issue>6</issue><spage>672</spage><epage>676</epage><pages>672-676</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Short-chain fatty acids (SCFA) and succinate in fresh feces from 10 healthy human volunteers were detected with gas-liquid chromatography and were correlated with their fecal cultural counts. The SCFA content of feces did not change significantly after freezing, but the cultural counts of total anaerobes and bifidobacteria showed significant changes (0.001 < P < 0.01). A significant negative correlation (r = -0.78; 0.01 < P < 0.02) was found between the bifidobacteria cultural counts and the succinic acid concentration in fresh feces, which disappeared after freezing of the samples. Because of the significant differences in cultural counts and the shift in significant correlations after freezing, it is important to use fresh fecal samples for these correlation studies. Lactic acid and i-caproic acid were not found in the fecal samples. The results show that SCFA and organic acid concentrations cannot replace (an)aerobe cultural counts in fecal flora studies of healthy human volunteers because of the low rate of significant correlations between these two.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>3659829</pmid><doi>10.3109/00365528709011141</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Scandinavian journal of gastroenterology, 1987, Vol.22 (6), p.672-676 |
| issn | 0036-5521 1502-7708 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adult Anaerobes Bacteria, Aerobic - analysis Bacteria, Anaerobic - analysis Biological and medical sciences Chromatography, Gas cultural counts Fatty Acids, Volatile - analysis Feces - analysis Feces - microbiology Fundamental and applied biological sciences. Psychology gas-liquid chromatography Humans Intestine. Mesentery Male Middle Aged short-chain fatty acids Specimen Handling succinate Succinates - analysis Vertebrates: digestive system |
| title | Short-Chain Fatty Acids and Succinate in Feces of Healthy Human Volunteers and Their Correlation with Anaerobe Cultural Counts |
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