Healing pattern of small caliber Dacron grafts in the baboon: An animal model for the study of vascular prostheses
Although dogs have been used widely to study the healing of large caliber synthetic grafts, hypercoagulability probably makes the dog a poor model for studies of small caliber vascular prostheses. The baboon's coagulation system is similar to man's, but large caliber baboon grafts were rep...
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| Veröffentlicht in: | Journal of biomedical materials research 1984-03, Vol.18 (3), p.281-292 |
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| container_title | Journal of biomedical materials research |
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| creator | Keough, E. M. Callow, A. D. Connolly, R. J. Weinberg, K. S. Aalberg, J. J. O'Donnell Jr, T. F. |
| description | Although dogs have been used widely to study the healing of large caliber synthetic grafts, hypercoagulability probably makes the dog a poor model for studies of small caliber vascular prostheses. The baboon's coagulation system is similar to man's, but large caliber baboon grafts were reported to endothelialize rapidly. In this study the healing pattern of 4mm internal diameter Dacron carotid interpositon grafts in baboons was determined using specimens harvested at time points between 2 weeks and 18 months post‐implantation and examined with light and scanning electron microscopy. The luminal surface of baboon grafts in the acute healing phase ( |
| doi_str_mv | 10.1002/jbm.820180305 |
| format | Article |
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M. ; Callow, A. D. ; Connolly, R. J. ; Weinberg, K. S. ; Aalberg, J. J. ; O'Donnell Jr, T. F.</creator><creatorcontrib>Keough, E. M. ; Callow, A. D. ; Connolly, R. J. ; Weinberg, K. S. ; Aalberg, J. J. ; O'Donnell Jr, T. F.</creatorcontrib><description>Although dogs have been used widely to study the healing of large caliber synthetic grafts, hypercoagulability probably makes the dog a poor model for studies of small caliber vascular prostheses. The baboon's coagulation system is similar to man's, but large caliber baboon grafts were reported to endothelialize rapidly. In this study the healing pattern of 4mm internal diameter Dacron carotid interpositon grafts in baboons was determined using specimens harvested at time points between 2 weeks and 18 months post‐implantation and examined with light and scanning electron microscopy. The luminal surface of baboon grafts in the acute healing phase (<1 month) was comparable to that reported in the literature for dogs. Baboon grafts did not completely endothelialize until 10–12 weeks post‐implantation. For work with small caliber vascular protheses, the dog appears to have no advantage over the baboon as an animal model on the basis of graft healing.</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/jbm.820180305</identifier><identifier>PMID: 6232280</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Vessel Prosthesis - adverse effects ; Carotid Arteries - physiology ; Carotid Arteries - surgery ; Endothelium - physiology ; Fundamental and applied biological sciences. Psychology ; General aspects ; Instrumentation. Materials. Reagents. 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M.</creatorcontrib><creatorcontrib>Callow, A. D.</creatorcontrib><creatorcontrib>Connolly, R. J.</creatorcontrib><creatorcontrib>Weinberg, K. S.</creatorcontrib><creatorcontrib>Aalberg, J. J.</creatorcontrib><creatorcontrib>O'Donnell Jr, T. F.</creatorcontrib><title>Healing pattern of small caliber Dacron grafts in the baboon: An animal model for the study of vascular prostheses</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Although dogs have been used widely to study the healing of large caliber synthetic grafts, hypercoagulability probably makes the dog a poor model for studies of small caliber vascular prostheses. The baboon's coagulation system is similar to man's, but large caliber baboon grafts were reported to endothelialize rapidly. In this study the healing pattern of 4mm internal diameter Dacron carotid interpositon grafts in baboons was determined using specimens harvested at time points between 2 weeks and 18 months post‐implantation and examined with light and scanning electron microscopy. The luminal surface of baboon grafts in the acute healing phase (<1 month) was comparable to that reported in the literature for dogs. Baboon grafts did not completely endothelialize until 10–12 weeks post‐implantation. For work with small caliber vascular protheses, the dog appears to have no advantage over the baboon as an animal model on the basis of graft healing.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Vessel Prosthesis - adverse effects</subject><subject>Carotid Arteries - physiology</subject><subject>Carotid Arteries - surgery</subject><subject>Endothelium - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Instrumentation. Materials. Reagents. 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D.</creatorcontrib><creatorcontrib>Connolly, R. J.</creatorcontrib><creatorcontrib>Weinberg, K. S.</creatorcontrib><creatorcontrib>Aalberg, J. J.</creatorcontrib><creatorcontrib>O'Donnell Jr, T. F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keough, E. M.</au><au>Callow, A. D.</au><au>Connolly, R. J.</au><au>Weinberg, K. S.</au><au>Aalberg, J. J.</au><au>O'Donnell Jr, T. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Healing pattern of small caliber Dacron grafts in the baboon: An animal model for the study of vascular prostheses</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>1984-03</date><risdate>1984</risdate><volume>18</volume><issue>3</issue><spage>281</spage><epage>292</epage><pages>281-292</pages><issn>0021-9304</issn><eissn>1097-4636</eissn><coden>JBMRBG</coden><abstract>Although dogs have been used widely to study the healing of large caliber synthetic grafts, hypercoagulability probably makes the dog a poor model for studies of small caliber vascular prostheses. The baboon's coagulation system is similar to man's, but large caliber baboon grafts were reported to endothelialize rapidly. In this study the healing pattern of 4mm internal diameter Dacron carotid interpositon grafts in baboons was determined using specimens harvested at time points between 2 weeks and 18 months post‐implantation and examined with light and scanning electron microscopy. The luminal surface of baboon grafts in the acute healing phase (<1 month) was comparable to that reported in the literature for dogs. Baboon grafts did not completely endothelialize until 10–12 weeks post‐implantation. For work with small caliber vascular protheses, the dog appears to have no advantage over the baboon as an animal model on the basis of graft healing.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>6232280</pmid><doi>10.1002/jbm.820180305</doi><tpages>12</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Biological and medical sciences Blood Vessel Prosthesis - adverse effects Carotid Arteries - physiology Carotid Arteries - surgery Endothelium - physiology Fundamental and applied biological sciences. Psychology General aspects Instrumentation. Materials. Reagents. Research laboratory organization Male Models, Biological Papio Polyethylene Terephthalates - pharmacology Wound Healing - drug effects |
| title | Healing pattern of small caliber Dacron grafts in the baboon: An animal model for the study of vascular prostheses |
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