A NEW ANTI-HUMAN IMMUNODEFICIENCY VIRUS SUBSTANCE, GLYCYRRHIZIN SULFATE; ENDOWMENT OF GLYCYRRHIZIN WITH REVERSE TRANSCRIPTASE-INHIBITORY ACTIVITY BY CHEMICAL MODIFICATION
Glycyrrhizin sulfate (GLS) was synthesized and investigated for antiviral effect on the human immunodeficiency virus (HIV) in vitro in comparison with the parental anti-HIV compound glycyrrhizin (GL). In MT-4 cells after HIV infection, the virus-induced cytopathic effect and the expression of viral...
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| Veröffentlicht in: | Japanese Journal of Cancer Research GANN 1987, Vol.78(8), pp.767-771 |
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| container_title | Japanese Journal of Cancer Research GANN |
| container_volume | 78 |
| creator | NAKASHIMA, Hideki MATSUI, Toshio YOSHIDA, Osamu ISOWA, Yoshikazu KIDO, Yasuji MOTOKI, Yoshinobu ITO, Masahiko SHIGETA, Shiro MORI, Takeo YAMAMOTO, Naoki |
| description | Glycyrrhizin sulfate (GLS) was synthesized and investigated for antiviral effect on the human immunodeficiency virus (HIV) in vitro in comparison with the parental anti-HIV compound glycyrrhizin (GL). In MT-4 cells after HIV infection, the virus-induced cytopathic effect and the expression of viral antigens were inhibited by 0.25mg/ml (0.184 mM) of GLS. Moreover, GLS completely inhibited HIV-induced plaque formation in MT-4 cells at a concentration of 1mg/ml (736μM), the 50% inhibitory dose being 0.055mg/ml (40μM). GLS was found to be an efficient inhibitor of reverse transcriptase. The effect of GLS was 4 times stronger than that of GL in molar terms. |
| doi_str_mv | 10.20772/cancersci1985.78.8_767 |
| format | Article |
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In MT-4 cells after HIV infection, the virus-induced cytopathic effect and the expression of viral antigens were inhibited by 0.25mg/ml (0.184 mM) of GLS. Moreover, GLS completely inhibited HIV-induced plaque formation in MT-4 cells at a concentration of 1mg/ml (736μM), the 50% inhibitory dose being 0.055mg/ml (40μM). GLS was found to be an efficient inhibitor of reverse transcriptase. The effect of GLS was 4 times stronger than that of GL in molar terms.</description><identifier>ISSN: 0910-5050</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.20772/cancersci1985.78.8_767</identifier><identifier>PMID: 2443473</identifier><identifier>CODEN: GANNA2</identifier><language>eng</language><publisher>Tokyo: The Japanese Cancer Association</publisher><subject>AIDS/HIV ; Anti-retroviral drug ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Glycyrrhetinic Acid - analogs & derivatives ; Glycyrrhetinic Acid - pharmacology ; Glycyrrhizic Acid ; Glycyrrhizin ; Glycyrrhizin sulfate ; HIV - drug effects ; Human immunodeficiency virus ; Medical sciences ; Pharmacology. Drug treatments ; Reverse transcriptase inhibitor ; Reverse Transcriptase Inhibitors ; Sulfuric Acids - pharmacology</subject><ispartof>Japanese Journal of Cancer Research GANN, 1987, Vol.78(8), pp.767-771</ispartof><rights>The Japanese Cancer Association</rights><rights>1988 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-99d362d61458443a5f2249865c945721cc5d7043b75266da17f9b74fd6f8fc243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7741681$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2443473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAKASHIMA, Hideki</creatorcontrib><creatorcontrib>MATSUI, Toshio</creatorcontrib><creatorcontrib>YOSHIDA, Osamu</creatorcontrib><creatorcontrib>ISOWA, Yoshikazu</creatorcontrib><creatorcontrib>KIDO, Yasuji</creatorcontrib><creatorcontrib>MOTOKI, Yoshinobu</creatorcontrib><creatorcontrib>ITO, Masahiko</creatorcontrib><creatorcontrib>SHIGETA, Shiro</creatorcontrib><creatorcontrib>MORI, Takeo</creatorcontrib><creatorcontrib>YAMAMOTO, Naoki</creatorcontrib><title>A NEW ANTI-HUMAN IMMUNODEFICIENCY VIRUS SUBSTANCE, GLYCYRRHIZIN SULFATE; ENDOWMENT OF GLYCYRRHIZIN WITH REVERSE TRANSCRIPTASE-INHIBITORY ACTIVITY BY CHEMICAL MODIFICATION</title><title>Japanese Journal of Cancer Research GANN</title><addtitle>Japanese Journal of Cancer Research GANN</addtitle><description>Glycyrrhizin sulfate (GLS) was synthesized and investigated for antiviral effect on the human immunodeficiency virus (HIV) in vitro in comparison with the parental anti-HIV compound glycyrrhizin (GL). In MT-4 cells after HIV infection, the virus-induced cytopathic effect and the expression of viral antigens were inhibited by 0.25mg/ml (0.184 mM) of GLS. Moreover, GLS completely inhibited HIV-induced plaque formation in MT-4 cells at a concentration of 1mg/ml (736μM), the 50% inhibitory dose being 0.055mg/ml (40μM). GLS was found to be an efficient inhibitor of reverse transcriptase. The effect of GLS was 4 times stronger than that of GL in molar terms.</description><subject>AIDS/HIV</subject><subject>Anti-retroviral drug</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Glycyrrhetinic Acid - analogs & derivatives</subject><subject>Glycyrrhetinic Acid - pharmacology</subject><subject>Glycyrrhizic Acid</subject><subject>Glycyrrhizin</subject><subject>Glycyrrhizin sulfate</subject><subject>HIV - drug effects</subject><subject>Human immunodeficiency virus</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Reverse transcriptase inhibitor</subject><subject>Reverse Transcriptase Inhibitors</subject><subject>Sulfuric Acids - pharmacology</subject><issn>0910-5050</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0UFvmzAUB3Br2tRl3T7CNB-mnUZmg7GNdiLEKZaCmcAkYhfkGNioSNpBcuhX6qccU1GnXmzJ_5-e3vMD4BNGSxcx5n6z5mSbYbQdDri_ZHzJK0bZK7DAnFGHUOa9BgsUYOT4yEdvwbtxvEUIM0TdK3DlEuIR5i3AYwiV2MNQaenERRIqKJOkUOlabGQkhYpKuJNZkcO8WOU6VJH4Cm-2ZVRmWSx_SjW9bzehFt-hUOt0nwilYbp5SfZSxzATO5HlAuosVHmUyR86zIUjVSxXUqdZCcNIy53UJVyVMIpFIqNwC5N0LadGQi1T9R68aU0_Nh_m-xoUG6Gj2NmmN_-wY4mPzk4Q1B51a4qJz6cpjd-6Lgk49W1AfOZia_2aIeIdmO9SWhvM2uDASFvTlrfWJd41-PJU9364-3NpxnN17Ebb9L05NXeXseIYeZwEwQQ_zvByODZ1dT90RzM8VPPnTvnnOTejNX07TCvrxmfGGMGU44nJJ3Y7ns2v5jk3w7mzfVO92HTFeMXng7L_5rcZqubk_QWKAZjT</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>NAKASHIMA, Hideki</creator><creator>MATSUI, Toshio</creator><creator>YOSHIDA, Osamu</creator><creator>ISOWA, Yoshikazu</creator><creator>KIDO, Yasuji</creator><creator>MOTOKI, Yoshinobu</creator><creator>ITO, Masahiko</creator><creator>SHIGETA, Shiro</creator><creator>MORI, Takeo</creator><creator>YAMAMOTO, Naoki</creator><general>The Japanese Cancer Association</general><general>Japanese Cancer Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>A NEW ANTI-HUMAN IMMUNODEFICIENCY VIRUS SUBSTANCE, GLYCYRRHIZIN SULFATE; ENDOWMENT OF GLYCYRRHIZIN WITH REVERSE TRANSCRIPTASE-INHIBITORY ACTIVITY BY CHEMICAL MODIFICATION</title><author>NAKASHIMA, Hideki ; MATSUI, Toshio ; YOSHIDA, Osamu ; ISOWA, Yoshikazu ; KIDO, Yasuji ; MOTOKI, Yoshinobu ; ITO, Masahiko ; SHIGETA, Shiro ; MORI, Takeo ; YAMAMOTO, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-99d362d61458443a5f2249865c945721cc5d7043b75266da17f9b74fd6f8fc243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>AIDS/HIV</topic><topic>Anti-retroviral drug</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Glycyrrhetinic Acid - analogs & derivatives</topic><topic>Glycyrrhetinic Acid - pharmacology</topic><topic>Glycyrrhizic Acid</topic><topic>Glycyrrhizin</topic><topic>Glycyrrhizin sulfate</topic><topic>HIV - drug effects</topic><topic>Human immunodeficiency virus</topic><topic>Medical sciences</topic><topic>Pharmacology. 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In MT-4 cells after HIV infection, the virus-induced cytopathic effect and the expression of viral antigens were inhibited by 0.25mg/ml (0.184 mM) of GLS. Moreover, GLS completely inhibited HIV-induced plaque formation in MT-4 cells at a concentration of 1mg/ml (736μM), the 50% inhibitory dose being 0.055mg/ml (40μM). GLS was found to be an efficient inhibitor of reverse transcriptase. The effect of GLS was 4 times stronger than that of GL in molar terms.</abstract><cop>Tokyo</cop><pub>The Japanese Cancer Association</pub><pmid>2443473</pmid><doi>10.20772/cancersci1985.78.8_767</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Journal of Cancer Research GANN, 1987, Vol.78(8), pp.767-771 |
| issn | 0910-5050 1876-4673 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | AIDS/HIV Anti-retroviral drug Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - pharmacology Glycyrrhizic Acid Glycyrrhizin Glycyrrhizin sulfate HIV - drug effects Human immunodeficiency virus Medical sciences Pharmacology. Drug treatments Reverse transcriptase inhibitor Reverse Transcriptase Inhibitors Sulfuric Acids - pharmacology |
| title | A NEW ANTI-HUMAN IMMUNODEFICIENCY VIRUS SUBSTANCE, GLYCYRRHIZIN SULFATE; ENDOWMENT OF GLYCYRRHIZIN WITH REVERSE TRANSCRIPTASE-INHIBITORY ACTIVITY BY CHEMICAL MODIFICATION |
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