A comparison of the LH-releasing activities of LH-RH and its agonistic analogue buserelin in the ovariectomized rat
LH-RH and the potent agonistic analogue (D-Ser(Bu t) 6-des-Gly 10)-LH-RH(1–9)-ethylamide ( (HOE-766 or buserelin) were at several doses either infused or injected intravenously in 5-weeks-ovariectomized rats, which had been treated with either 3 μg estradiol-benzoate (EB) or with oil, 24 h previousl...
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| Veröffentlicht in: | Life sciences (1973) 1984-04, Vol.34 (16), p.1597-1604 |
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| container_title | Life sciences (1973) |
| container_volume | 34 |
| creator | Koiter, T.R. van der Schaaf-Verdonk, G.C.J. Kuiper, H. Pols-Valkhof, N. Schuiling, G.A. |
| description | LH-RH and the potent agonistic analogue (D-Ser(Bu
t)
6-des-Gly
10)-LH-RH(1–9)-ethylamide ( (HOE-766 or buserelin) were at several doses either infused or injected intravenously in 5-weeks-ovariectomized rats, which had been treated with either 3 μg estradiol-benzoate (EB) or with oil, 24 h previously. Blood samples for assay of LH were taken during the subsequent 24 h. Potuitary glands were removed at the end of the experiments. Buserelin, when infused, was slightly more effective than LH-RH in releasing LH. When injected, however, buserelin was at the higher dose ranges increasingly more effective as an LH-releasing agent than LH-RH. EB-treatment increased the LH response of the pituitary gland to both peptides in an identical way. It was concluded that buserelin derives its high potency not from its intrinsic LH-releasing activity, which is only slightly greater than that of LH-RH, but from a longer duration of action. |
| doi_str_mv | 10.1016/0024-3205(84)90615-5 |
| format | Article |
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t)
6-des-Gly
10)-LH-RH(1–9)-ethylamide ( (HOE-766 or buserelin) were at several doses either infused or injected intravenously in 5-weeks-ovariectomized rats, which had been treated with either 3 μg estradiol-benzoate (EB) or with oil, 24 h previously. Blood samples for assay of LH were taken during the subsequent 24 h. Potuitary glands were removed at the end of the experiments. Buserelin, when infused, was slightly more effective than LH-RH in releasing LH. When injected, however, buserelin was at the higher dose ranges increasingly more effective as an LH-releasing agent than LH-RH. EB-treatment increased the LH response of the pituitary gland to both peptides in an identical way. It was concluded that buserelin derives its high potency not from its intrinsic LH-releasing activity, which is only slightly greater than that of LH-RH, but from a longer duration of action.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(84)90615-5</identifier><identifier>PMID: 6425589</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Buserelin - pharmacology ; Castration ; Dose-Response Relationship, Drug ; Female ; Fundamental and applied biological sciences. Psychology ; Gonadotropin-Releasing Hormone - pharmacology ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Luteinizing Hormone - blood ; Luteinizing Hormone - metabolism ; Ovary - physiology ; Rats ; Rats, Inbred Strains ; Vertebrates: endocrinology</subject><ispartof>Life sciences (1973), 1984-04, Vol.34 (16), p.1597-1604</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-408fb16e0091b3e774dd8a6a14d098efa6e63987f6589d9516a32e8fb084bc043</citedby><cites>FETCH-LOGICAL-c386t-408fb16e0091b3e774dd8a6a14d098efa6e63987f6589d9516a32e8fb084bc043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0024320584906155$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8903847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6425589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koiter, T.R.</creatorcontrib><creatorcontrib>van der Schaaf-Verdonk, G.C.J.</creatorcontrib><creatorcontrib>Kuiper, H.</creatorcontrib><creatorcontrib>Pols-Valkhof, N.</creatorcontrib><creatorcontrib>Schuiling, G.A.</creatorcontrib><title>A comparison of the LH-releasing activities of LH-RH and its agonistic analogue buserelin in the ovariectomized rat</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>LH-RH and the potent agonistic analogue (D-Ser(Bu
t)
6-des-Gly
10)-LH-RH(1–9)-ethylamide ( (HOE-766 or buserelin) were at several doses either infused or injected intravenously in 5-weeks-ovariectomized rats, which had been treated with either 3 μg estradiol-benzoate (EB) or with oil, 24 h previously. Blood samples for assay of LH were taken during the subsequent 24 h. Potuitary glands were removed at the end of the experiments. Buserelin, when infused, was slightly more effective than LH-RH in releasing LH. When injected, however, buserelin was at the higher dose ranges increasingly more effective as an LH-releasing agent than LH-RH. EB-treatment increased the LH response of the pituitary gland to both peptides in an identical way. It was concluded that buserelin derives its high potency not from its intrinsic LH-releasing activity, which is only slightly greater than that of LH-RH, but from a longer duration of action.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Buserelin - pharmacology</subject><subject>Castration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Ovary - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: endocrinology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF2L1DAYhYMo67j6DxRyIYtedH3TfDS9EZZFHWFAEL0Oafp2jLTNmKQD7q_f1BnmUggUcp5zSB9CXjO4ZcDUB4BaVLwG-U6L9y0oJiv5hGyYbtoKFGdPyeaCPCcvUvoNAFI2_IpcKVFLqdsNSXfUhelgo09hpmGg-RfS3baKOKJNft5T67I_-uwxrXGJvm-pnXvqc6J2H2afsnflxo5hvyDtloSl7GdazjoWjmUcXQ6Tf8CeRptfkmeDHRO-On-vyc_Pn37cb6vdty9f7-92leNa5UqAHjqmEKBlHcemEX2vrbJM9NBqHKxCxVvdDKr8Sd9KpiyvsXRAi86B4Nfk5rR7iOHPgimbySeH42hnDEsymgFv6poXUJxAF0NKEQdziH6y8a9hYFbXZhVpVpFGC_PPtZGl9ua8v3QT9pfSWW7J355zm5wdh2hn59MF0y1wLZqCfTxhWFwcPUaTnMfZYe9j8Wb64P__jkdIApps</recordid><startdate>19840416</startdate><enddate>19840416</enddate><creator>Koiter, T.R.</creator><creator>van der Schaaf-Verdonk, G.C.J.</creator><creator>Kuiper, H.</creator><creator>Pols-Valkhof, N.</creator><creator>Schuiling, G.A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840416</creationdate><title>A comparison of the LH-releasing activities of LH-RH and its agonistic analogue buserelin in the ovariectomized rat</title><author>Koiter, T.R. ; van der Schaaf-Verdonk, G.C.J. ; Kuiper, H. ; Pols-Valkhof, N. ; Schuiling, G.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-408fb16e0091b3e774dd8a6a14d098efa6e63987f6589d9516a32e8fb084bc043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Buserelin - pharmacology</topic><topic>Castration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Ovary - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koiter, T.R.</creatorcontrib><creatorcontrib>van der Schaaf-Verdonk, G.C.J.</creatorcontrib><creatorcontrib>Kuiper, H.</creatorcontrib><creatorcontrib>Pols-Valkhof, N.</creatorcontrib><creatorcontrib>Schuiling, G.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koiter, T.R.</au><au>van der Schaaf-Verdonk, G.C.J.</au><au>Kuiper, H.</au><au>Pols-Valkhof, N.</au><au>Schuiling, G.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the LH-releasing activities of LH-RH and its agonistic analogue buserelin in the ovariectomized rat</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1984-04-16</date><risdate>1984</risdate><volume>34</volume><issue>16</issue><spage>1597</spage><epage>1604</epage><pages>1597-1604</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>LH-RH and the potent agonistic analogue (D-Ser(Bu
t)
6-des-Gly
10)-LH-RH(1–9)-ethylamide ( (HOE-766 or buserelin) were at several doses either infused or injected intravenously in 5-weeks-ovariectomized rats, which had been treated with either 3 μg estradiol-benzoate (EB) or with oil, 24 h previously. Blood samples for assay of LH were taken during the subsequent 24 h. Potuitary glands were removed at the end of the experiments. Buserelin, when infused, was slightly more effective than LH-RH in releasing LH. When injected, however, buserelin was at the higher dose ranges increasingly more effective as an LH-releasing agent than LH-RH. EB-treatment increased the LH response of the pituitary gland to both peptides in an identical way. It was concluded that buserelin derives its high potency not from its intrinsic LH-releasing activity, which is only slightly greater than that of LH-RH, but from a longer duration of action.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>6425589</pmid><doi>10.1016/0024-3205(84)90615-5</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Buserelin - pharmacology Castration Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Gonadotropin-Releasing Hormone - pharmacology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Luteinizing Hormone - blood Luteinizing Hormone - metabolism Ovary - physiology Rats Rats, Inbred Strains Vertebrates: endocrinology |
| title | A comparison of the LH-releasing activities of LH-RH and its agonistic analogue buserelin in the ovariectomized rat |
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