Neural plasticity of basal forebrain cholinergic neurons: effects of gangliosides
Nucleus basalis magnocellularis (NBM) cholinergic neurons, furnishing the major portion of the extrinsic cholinergic innervation of the rat cortex, undergo specific retrograde changes in cell somata and choline acetyltransferase (ChAT) activity after cortical lesions. These are prevented in young an...
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| Veröffentlicht in: | Neuroscience letters 1987-09, Vol.80 (1), p.80-84 |
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| container_title | Neuroscience letters |
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| creator | Stephens, P.H. Tagari, P.C. Garofalo, L. Maysinger, D. Piotte, M. Cuello, A.C. |
| description | Nucleus basalis magnocellularis (NBM) cholinergic neurons, furnishing the major portion of the extrinsic cholinergic innervation of the rat cortex, undergo specific retrograde changes in cell somata and choline acetyltransferase (ChAT) activity after cortical lesions. These are prevented in young and mature animals, but not in aged rats, by the chronic administration of exogenous ganglioside GM
1 after lesioning. However, a delay of 10 days (in young animals) in the commencement of treatment averted the responses to GM
1 in lesioned animals. It is suggested that the effects of exogenous gangliosides on retrograde biochemical and morphological alteration of cholinergic neurons may vary with circumstances permissive of plastic changes of central nervous system neurons at the time of administration. |
| doi_str_mv | 10.1016/0304-3940(87)90499-X |
| format | Article |
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1 after lesioning. However, a delay of 10 days (in young animals) in the commencement of treatment averted the responses to GM
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1 after lesioning. However, a delay of 10 days (in young animals) in the commencement of treatment averted the responses to GM
1 in lesioned animals. It is suggested that the effects of exogenous gangliosides on retrograde biochemical and morphological alteration of cholinergic neurons may vary with circumstances permissive of plastic changes of central nervous system neurons at the time of administration.</description><subject>Acetylcholine</subject><subject>Animals</subject><subject>Basal Ganglia - cytology</subject><subject>Basal Ganglia - drug effects</subject><subject>Basal Ganglia - enzymology</subject><subject>Biological and medical sciences</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Cholinergic Fibers - drug effects</subject><subject>Cholinergic Fibers - enzymology</subject><subject>Cholinergic Fibers - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G(M1) Ganglioside - pharmacology</subject><subject>Ganglioside</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Neural plasticity</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Nucleus basalis</subject><subject>Rat</subject><subject>Rats</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFEEQhhsxxDXmHyjMQYI5TOye_s4hEIIxQogICrk1PdXVa8vs9No9K-TfZza77NFTQdXzvhQPIe8ZvWCUqc-UU9FyK-gno88tFda2j6_Ighndtdrq7jVZHJA35G2tfyilkklxTI65kqbjckF-POCm-KFZD75OCdL01OTY9L7Ou5gL9sWnsYHfeUgjlmWCZpwDeayXDcaIMNUtv_Tjcki5poD1HTmKfqh4up8n5Nftl583d-3996_fbq7vW-BGTa0S2AvLDZPKAO8CRE0hBEDKAguCRiWDocpCL7SMnbDGqgB9MBKFVbHnJ-Rs17su-e8G6-RWqQIOgx8xb6ozjHKptZhBsQOh5FoLRrcuaeXLk2PUbU26rSa31eSMdi8m3eMc-7Dv3_QrDIfQXt18_7i_-wp-iMWPkOoB00Jao7oZu9phOLv4l7C4CglHwJDKrM-FnP7_xzMxTJBT</recordid><startdate>19870911</startdate><enddate>19870911</enddate><creator>Stephens, P.H.</creator><creator>Tagari, P.C.</creator><creator>Garofalo, L.</creator><creator>Maysinger, D.</creator><creator>Piotte, M.</creator><creator>Cuello, A.C.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870911</creationdate><title>Neural plasticity of basal forebrain cholinergic neurons: effects of gangliosides</title><author>Stephens, P.H. ; Tagari, P.C. ; Garofalo, L. ; Maysinger, D. ; Piotte, M. ; Cuello, A.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-64eb49381568c32dcf70cddce01d1d40f65d8069cb475f249896dcbd85e496fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acetylcholine</topic><topic>Animals</topic><topic>Basal Ganglia - cytology</topic><topic>Basal Ganglia - drug effects</topic><topic>Basal Ganglia - enzymology</topic><topic>Biological and medical sciences</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Cholinergic Fibers - drug effects</topic><topic>Cholinergic Fibers - enzymology</topic><topic>Cholinergic Fibers - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G(M1) Ganglioside - pharmacology</topic><topic>Ganglioside</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Neural plasticity</topic><topic>Neuronal Plasticity - drug effects</topic><topic>Nucleus basalis</topic><topic>Rat</topic><topic>Rats</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stephens, P.H.</creatorcontrib><creatorcontrib>Tagari, P.C.</creatorcontrib><creatorcontrib>Garofalo, L.</creatorcontrib><creatorcontrib>Maysinger, D.</creatorcontrib><creatorcontrib>Piotte, M.</creatorcontrib><creatorcontrib>Cuello, A.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stephens, P.H.</au><au>Tagari, P.C.</au><au>Garofalo, L.</au><au>Maysinger, D.</au><au>Piotte, M.</au><au>Cuello, A.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural plasticity of basal forebrain cholinergic neurons: effects of gangliosides</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1987-09-11</date><risdate>1987</risdate><volume>80</volume><issue>1</issue><spage>80</spage><epage>84</epage><pages>80-84</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Nucleus basalis magnocellularis (NBM) cholinergic neurons, furnishing the major portion of the extrinsic cholinergic innervation of the rat cortex, undergo specific retrograde changes in cell somata and choline acetyltransferase (ChAT) activity after cortical lesions. These are prevented in young and mature animals, but not in aged rats, by the chronic administration of exogenous ganglioside GM
1 after lesioning. However, a delay of 10 days (in young animals) in the commencement of treatment averted the responses to GM
1 in lesioned animals. It is suggested that the effects of exogenous gangliosides on retrograde biochemical and morphological alteration of cholinergic neurons may vary with circumstances permissive of plastic changes of central nervous system neurons at the time of administration.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3658235</pmid><doi>10.1016/0304-3940(87)90499-X</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1987-09, Vol.80 (1), p.80-84 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acetylcholine Animals Basal Ganglia - cytology Basal Ganglia - drug effects Basal Ganglia - enzymology Biological and medical sciences Choline O-Acetyltransferase - metabolism Cholinergic Fibers - drug effects Cholinergic Fibers - enzymology Cholinergic Fibers - physiology Fundamental and applied biological sciences. Psychology G(M1) Ganglioside - pharmacology Ganglioside Isolated neuron and nerve. Neuroglia Neural plasticity Neuronal Plasticity - drug effects Nucleus basalis Rat Rats Vertebrates: nervous system and sense organs |
| title | Neural plasticity of basal forebrain cholinergic neurons: effects of gangliosides |
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