Pathogenetic Studies of Cardiac Allograft Rejection Using Inbred Rat Models
Applying established genetic data for selection of the appropriate donor-recipient strain combinations, the authors have carried out a series of comparative morphologic studies of the pathogenesis of humoral-mediated hyperacute rejection and of acute cellular rejection in the inbred rat cardiac mode...
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| Veröffentlicht in: | Immunological reviews 1984-01, Vol.77 (1), p.5-29 |
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| container_title | Immunological reviews |
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| creator | Forbes, R. D. C. Guttmann, R. D. |
| description | Applying established genetic data for selection of the appropriate donor-recipient strain combinations, the authors have carried out a series of comparative morphologic studies of the pathogenesis of humoral-mediated hyperacute rejection and of acute cellular rejection in the inbred rat cardiac model. These studies, using inbred rat cardiac models in the appropriate strain combinations, have demonstrated the usefulness of systematic comparative morphologic analysis in the elucidation of the pathogenesis of organ allograft rejection. Such investigations provide significant additional insight into the nature of these complex and varied forms of lethal organ injury. |
| doi_str_mv | 10.1111/j.1600-065X.1984.tb00716.x |
| format | Article |
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D. C.</creatorcontrib><creatorcontrib>Guttmann, R. D.</creatorcontrib><title>Pathogenetic Studies of Cardiac Allograft Rejection Using Inbred Rat Models</title><title>Immunological reviews</title><addtitle>Immunol Rev</addtitle><description>Applying established genetic data for selection of the appropriate donor-recipient strain combinations, the authors have carried out a series of comparative morphologic studies of the pathogenesis of humoral-mediated hyperacute rejection and of acute cellular rejection in the inbred rat cardiac model. These studies, using inbred rat cardiac models in the appropriate strain combinations, have demonstrated the usefulness of systematic comparative morphologic analysis in the elucidation of the pathogenesis of organ allograft rejection. Such investigations provide significant additional insight into the nature of these complex and varied forms of lethal organ injury.</description><subject>Animals</subject><subject>Blood Platelets - immunology</subject><subject>Complement System Proteins - immunology</subject><subject>Coronary Circulation</subject><subject>Coronary Vessels - pathology</subject><subject>Endothelium - pathology</subject><subject>Graft Rejection</subject><subject>Heart Transplantation</subject><subject>Histocompatibility Antigens - immunology</subject><subject>Immunization, Passive</subject><subject>Immunologic Techniques</subject><subject>Leukocytes - immunology</subject><subject>Microcirculation</subject><subject>Myocardium - immunology</subject><subject>Myocardium - pathology</subject><subject>Myocardium - ultrastructure</subject><subject>Neutrophils - immunology</subject><subject>Platelet Aggregation</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Transplantation, Homologous</subject><issn>0105-2896</issn><issn>1600-065X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1v0zAYx62JaSuDjzDJ4sAtwY5fg7hMFawV3QaFaYiLZTtOcUmTYbui-_Y4atXrxCNLz-H_Yj0_AN5gVOI879Yl5ggViLMfJa4lLZNBSGBe7k7A5Ci9ABOEESsqWfNz8DLGNUJYkIqegTNOBJKETsDnLzr9Glaud8lb-C1tG-8iHFo41aHx2sKrrhtWQbcJLt3a2eSHHt5H36_gvDfBNXCpE7wZGtfFV-C01V10rw_7Atx_-vh9OisWd9fz6dWisJRwVlhjibBM1lg02LaUS8Jb45DWDaOVpNpwYURLTE1IlR0sn8wkNQ3lJhdQcgHe7nsfw_Bn62JSGx-t6zrdu2EblcSIMJLfc0ZMJCOZUTa-3xttGGIMrlWPwW90eFIYqRG5WquRqxq5qhG5OiBXuxy-PPyyNRvXHKMHxln_sNf_-s49_Uezmt8sxyOKfdzH5HbHuA6_FRdEMPVwe61ms2rB6-VP9ZX8AznRnu4</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Forbes, R. D. C.</creator><creator>Guttmann, R. D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Pathogenetic Studies of Cardiac Allograft Rejection Using Inbred Rat Models</title><author>Forbes, R. D. C. ; Guttmann, R. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4365-cbc37c58917d1cf46836fbe0aad54284ab67b7f3b9332d1c5111584bd46b43643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Blood Platelets - immunology</topic><topic>Complement System Proteins - immunology</topic><topic>Coronary Circulation</topic><topic>Coronary Vessels - pathology</topic><topic>Endothelium - pathology</topic><topic>Graft Rejection</topic><topic>Heart Transplantation</topic><topic>Histocompatibility Antigens - immunology</topic><topic>Immunization, Passive</topic><topic>Immunologic Techniques</topic><topic>Leukocytes - immunology</topic><topic>Microcirculation</topic><topic>Myocardium - immunology</topic><topic>Myocardium - pathology</topic><topic>Myocardium - ultrastructure</topic><topic>Neutrophils - immunology</topic><topic>Platelet Aggregation</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forbes, R. D. C.</creatorcontrib><creatorcontrib>Guttmann, R. D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunological reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forbes, R. D. C.</au><au>Guttmann, R. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathogenetic Studies of Cardiac Allograft Rejection Using Inbred Rat Models</atitle><jtitle>Immunological reviews</jtitle><addtitle>Immunol Rev</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>77</volume><issue>1</issue><spage>5</spage><epage>29</epage><pages>5-29</pages><issn>0105-2896</issn><eissn>1600-065X</eissn><abstract>Applying established genetic data for selection of the appropriate donor-recipient strain combinations, the authors have carried out a series of comparative morphologic studies of the pathogenesis of humoral-mediated hyperacute rejection and of acute cellular rejection in the inbred rat cardiac model. These studies, using inbred rat cardiac models in the appropriate strain combinations, have demonstrated the usefulness of systematic comparative morphologic analysis in the elucidation of the pathogenesis of organ allograft rejection. Such investigations provide significant additional insight into the nature of these complex and varied forms of lethal organ injury.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6370834</pmid><doi>10.1111/j.1600-065X.1984.tb00716.x</doi><tpages>25</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0105-2896 |
| ispartof | Immunological reviews, 1984-01, Vol.77 (1), p.5-29 |
| issn | 0105-2896 1600-065X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81035335 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Blood Platelets - immunology Complement System Proteins - immunology Coronary Circulation Coronary Vessels - pathology Endothelium - pathology Graft Rejection Heart Transplantation Histocompatibility Antigens - immunology Immunization, Passive Immunologic Techniques Leukocytes - immunology Microcirculation Myocardium - immunology Myocardium - pathology Myocardium - ultrastructure Neutrophils - immunology Platelet Aggregation Rats Rats, Inbred Strains Transplantation, Homologous |
| title | Pathogenetic Studies of Cardiac Allograft Rejection Using Inbred Rat Models |
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