The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition of HLA are located in this site, in positions...

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Veröffentlicht in:	Nature (London) 1987-10, Vol.329 (6139), p.512-518
Hauptverfasser:	Bjorkman, P. J, Saper, M. A, Samraoui, B, Bennett, W. S, Strominger, J. L, Wiley, D. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis of the immune response. Humoral and cellular immunity Antigens - metabolism Binding Sites Biochemistry Biological and medical sciences Computer Graphics Cytotoxicity, Immunologic Epitopes Fundamental and applied biological sciences. Psychology Fundamental immunology HLA Antigens - metabolism HLA-A2 Antigen Humans Immunity (Disease) Immunobiology Models, Molecular Organs and cells involved in the immune response Polymorphism, Genetic Protein Conformation Receptors, Immunologic - metabolism T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology
Online-Zugang:	Volltext
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