Enhanced Natural Killer Sensitivity With Concomitant Clonal Selection for Cells Bearing Homogeneously Staining Regions in the Human Melanoma Cell Line MeWo Upon Induction of Differentiation With Theophylline

Culture of the human melanoma cell line MeWo in the presence of 1 mM theophylline was associated with an increase in susceptibility to natural killer (NK)-mediated cytolysis. The phenomenon was detected as early as 72 hours after initiation of theophylline treatment, reaching maximum values at 3–4 w...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1984-05, Vol.72 (5), p.991-998
Hauptverfasser:	Haliotis, T., Werkmeister, J. A., Louwman, I., Liao, S.-K., Matthews, J., Riopelle, R., Pross, H. F., Holden, J. J. A., White, B. N., Smith, A., Roder, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Cycle Cell Differentiation - drug effects Cell Line Clone Cells Cytotoxicity, Immunologic Dermatology Flow Cytometry Humans Interferons - pharmacology Karyotyping Killer Cells, Natural - immunology Kinetics Medical sciences Melanoma - genetics Melanoma - pathology Theophylline - pharmacology Tumors of the skin and soft tissue. Premalignant lesions
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