Pulmonary vascular disease in fatal meconium aspiration
Although not proved, it is generally accepted that pulmonary vasospasm is responsible for the persistent pulmonary hypertension frequently associated with meconium aspiration. We have studied the pulmonary vasculature in 11 consecutive infants with fatal meconium aspiration, applying morphometric te...
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| Veröffentlicht in: | The Journal of pediatrics 1984-01, Vol.104 (5), p.758-762 |
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| container_title | The Journal of pediatrics |
| container_volume | 104 |
| creator | Murphy, John D. Vawter, Gordon F. Reid, Lynne M. |
| description | Although not proved, it is generally accepted that pulmonary vasospasm is responsible for the persistent pulmonary hypertension frequently associated with meconium aspiration. We have studied the pulmonary vasculature in 11 consecutive infants with fatal meconium aspiration, applying morphometric techniques to pulmonaryarteries distended with barium gelatin before fixation. In 10 of the 11 infants, persistent pulmonary hypertension was evident clinically, with right-to-left shunting through the foramen ovale or ductus arteriosus. In all but one, severe structural abnormal muscularization of the smallest intra-acinar arteries was present. These changes must have developed before birth. In only one infant was the structure of the intra-acinar precapillary arteries virtually normal, as would be expected if vasospasm alone had caused the hypertension. The persistent pulmonary hypertension associated with fatal meconium aspiration may be the result of a structurally abnormal pulmonary microcirculation. |
| doi_str_mv | 10.1016/S0022-3476(84)80962-2 |
| format | Article |
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We have studied the pulmonary vasculature in 11 consecutive infants with fatal meconium aspiration, applying morphometric techniques to pulmonaryarteries distended with barium gelatin before fixation. In 10 of the 11 infants, persistent pulmonary hypertension was evident clinically, with right-to-left shunting through the foramen ovale or ductus arteriosus. In all but one, severe structural abnormal muscularization of the smallest intra-acinar arteries was present. These changes must have developed before birth. In only one infant was the structure of the intra-acinar precapillary arteries virtually normal, as would be expected if vasospasm alone had caused the hypertension. 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Sudden death ; Female ; Humans ; Hypertension, Pulmonary - etiology ; Infant, Newborn ; Intensive care medicine ; Lung - blood supply ; Meconium ; Medical sciences ; Microcirculation - pathology ; Pneumonia, Aspiration - etiology ; Pregnancy ; Pulmonary Artery - pathology ; Vascular Diseases - etiology</subject><ispartof>The Journal of pediatrics, 1984-01, Vol.104 (5), p.758-762</ispartof><rights>1984 The C. V. 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We have studied the pulmonary vasculature in 11 consecutive infants with fatal meconium aspiration, applying morphometric techniques to pulmonaryarteries distended with barium gelatin before fixation. In 10 of the 11 infants, persistent pulmonary hypertension was evident clinically, with right-to-left shunting through the foramen ovale or ductus arteriosus. In all but one, severe structural abnormal muscularization of the smallest intra-acinar arteries was present. These changes must have developed before birth. In only one infant was the structure of the intra-acinar precapillary arteries virtually normal, as would be expected if vasospasm alone had caused the hypertension. The persistent pulmonary hypertension associated with fatal meconium aspiration may be the result of a structurally abnormal pulmonary microcirculation.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Lung - blood supply</subject><subject>Meconium</subject><subject>Medical sciences</subject><subject>Microcirculation - pathology</subject><subject>Pneumonia, Aspiration - etiology</subject><subject>Pregnancy</subject><subject>Pulmonary Artery - pathology</subject><subject>Vascular Diseases - etiology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMo4zj6CANdiOiienJpmq5EBm8woODsQ5qcQqSXMWkHfHs7F2br6izO95_LR8icwj0FKh--ABhLucjlrRJ3CgrJUnZCphSKPJWK81MyPSLn5CLGbwAoBMCETGROJWN8SvLPoW661oTfZGOiHWoTEucjmoiJb5PK9KZOGrRd64cmMXHtg-l9116Ss8rUEa8OdUZWL8-rxVu6_Hh9XzwtUyuo6lNkrDCcFdwpbpzktBIURO7QUWQik1Ka7SWg8rJUTjpLbcYNyKwsypIpPiM3-7Hr0P0MGHvd-Gixrk2L3RC1osCp4MUIZnvQhi7GgJVeB9-Mb2kKeutL73zprQythN750mzMzQ8LhrJBd0wdBI3960N_tGPqKpjW-njECkkVzWHEHvcYji42HoOO1mNr0fmAtteu8_8c8gcsHIXR</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Murphy, John D.</creator><creator>Vawter, Gordon F.</creator><creator>Reid, Lynne M.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Pulmonary vascular disease in fatal meconium aspiration</title><author>Murphy, John D. ; Vawter, Gordon F. ; Reid, Lynne M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-e229a3293d83ad631f41047ded1e245666a7162087bb8d6dc1c53a065b9bb283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Lung - blood supply</topic><topic>Meconium</topic><topic>Medical sciences</topic><topic>Microcirculation - pathology</topic><topic>Pneumonia, Aspiration - etiology</topic><topic>Pregnancy</topic><topic>Pulmonary Artery - pathology</topic><topic>Vascular Diseases - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murphy, John D.</creatorcontrib><creatorcontrib>Vawter, Gordon F.</creatorcontrib><creatorcontrib>Reid, Lynne M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murphy, John D.</au><au>Vawter, Gordon F.</au><au>Reid, Lynne M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary vascular disease in fatal meconium aspiration</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>104</volume><issue>5</issue><spage>758</spage><epage>762</epage><pages>758-762</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Although not proved, it is generally accepted that pulmonary vasospasm is responsible for the persistent pulmonary hypertension frequently associated with meconium aspiration. We have studied the pulmonary vasculature in 11 consecutive infants with fatal meconium aspiration, applying morphometric techniques to pulmonaryarteries distended with barium gelatin before fixation. In 10 of the 11 infants, persistent pulmonary hypertension was evident clinically, with right-to-left shunting through the foramen ovale or ductus arteriosus. In all but one, severe structural abnormal muscularization of the smallest intra-acinar arteries was present. These changes must have developed before birth. In only one infant was the structure of the intra-acinar precapillary arteries virtually normal, as would be expected if vasospasm alone had caused the hypertension. The persistent pulmonary hypertension associated with fatal meconium aspiration may be the result of a structurally abnormal pulmonary microcirculation.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>6716223</pmid><doi>10.1016/S0022-3476(84)80962-2</doi><tpages>5</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Humans Hypertension, Pulmonary - etiology Infant, Newborn Intensive care medicine Lung - blood supply Meconium Medical sciences Microcirculation - pathology Pneumonia, Aspiration - etiology Pregnancy Pulmonary Artery - pathology Vascular Diseases - etiology |
| title | Pulmonary vascular disease in fatal meconium aspiration |
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