Serial passage of tumors in mice in the study of tumor progression and testing of antineoplastic drugs

AKR lymphoma cells derived from spontaneous tumors were serially transplanted at identical inocula. The degree of malignancy and sensitivity to the polysaccharide levan and methotrexate were tested at each transfer by assessing the lag of development of primary and distant tumors and survival of mic...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1984-05, Vol.44 (5), p.1981-1984
1. Verfasser:	LEIBOVICI, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Division - drug effects Cell Survival - drug effects Drug Evaluation, Preclinical - methods Fructans - therapeutic use General aspects Lymphoma - drug therapy Lymphoma - physiopathology Male Medical sciences Methotrexate - therapeutic use Mice Mice, Inbred AKR Neoplasm Transplantation Pharmacology. Drug treatments
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container_end_page	1984
container_issue	5
container_start_page	1981
container_title	Cancer research (Chicago, Ill.)
container_volume	44
creator	LEIBOVICI, J
description	AKR lymphoma cells derived from spontaneous tumors were serially transplanted at identical inocula. The degree of malignancy and sensitivity to the polysaccharide levan and methotrexate were tested at each transfer by assessing the lag of development of primary and distant tumors and survival of mice. A progressive increase in malignancy, accompanied by a loss of sensitivity to levan, were observed following serial passage of the lymphoma. Sensitivity to methotrexate was not affected. It is reasoned that, since serial passages permit a longer exposure of the tumor cells to selective forces of the internal milieu of the organism, better reflecting the situation in a long-life span animal, spontaneous and serial-passage tumors could serve as models for cancer therapy in humans.
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The degree of malignancy and sensitivity to the polysaccharide levan and methotrexate were tested at each transfer by assessing the lag of development of primary and distant tumors and survival of mice. A progressive increase in malignancy, accompanied by a loss of sensitivity to levan, were observed following serial passage of the lymphoma. Sensitivity to methotrexate was not affected. It is reasoned that, since serial passages permit a longer exposure of the tumor cells to selective forces of the internal milieu of the organism, better reflecting the situation in a long-life span animal, spontaneous and serial-passage tumors could serve as models for cancer therapy in humans.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 6713396</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Cell Division - drug effects ; Cell Survival - drug effects ; Drug Evaluation, Preclinical - methods ; Fructans - therapeutic use ; General aspects ; Lymphoma - drug therapy ; Lymphoma - physiopathology ; Male ; Medical sciences ; Methotrexate - therapeutic use ; Mice ; Mice, Inbred AKR ; Neoplasm Transplantation ; Pharmacology. 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The degree of malignancy and sensitivity to the polysaccharide levan and methotrexate were tested at each transfer by assessing the lag of development of primary and distant tumors and survival of mice. A progressive increase in malignancy, accompanied by a loss of sensitivity to levan, were observed following serial passage of the lymphoma. Sensitivity to methotrexate was not affected. It is reasoned that, since serial passages permit a longer exposure of the tumor cells to selective forces of the internal milieu of the organism, better reflecting the situation in a long-life span animal, spontaneous and serial-passage tumors could serve as models for cancer therapy in humans.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Fructans - therapeutic use</subject><subject>General aspects</subject><subject>Lymphoma - drug therapy</subject><subject>Lymphoma - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methotrexate - therapeutic use</subject><subject>Mice</subject><subject>Mice, Inbred AKR</subject><subject>Neoplasm Transplantation</subject><subject>Pharmacology. 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The degree of malignancy and sensitivity to the polysaccharide levan and methotrexate were tested at each transfer by assessing the lag of development of primary and distant tumors and survival of mice. A progressive increase in malignancy, accompanied by a loss of sensitivity to levan, were observed following serial passage of the lymphoma. Sensitivity to methotrexate was not affected. It is reasoned that, since serial passages permit a longer exposure of the tumor cells to selective forces of the internal milieu of the organism, better reflecting the situation in a long-life span animal, spontaneous and serial-passage tumors could serve as models for cancer therapy in humans.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>6713396</pmid><tpages>4</tpages></addata></record>
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source	MEDLINE; EZB Electronic Journals Library; Highwire Press American Association for Cancer Research - AACR Journals
subjects	Animals Antineoplastic agents Biological and medical sciences Cell Division - drug effects Cell Survival - drug effects Drug Evaluation, Preclinical - methods Fructans - therapeutic use General aspects Lymphoma - drug therapy Lymphoma - physiopathology Male Medical sciences Methotrexate - therapeutic use Mice Mice, Inbred AKR Neoplasm Transplantation Pharmacology. Drug treatments
title	Serial passage of tumors in mice in the study of tumor progression and testing of antineoplastic drugs
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