Induction of monocytic differentiation of HL-60 cells by 1,25-dihydroxyvitamin D analogs

1,25-Dihydroxyvitamin D3, the hormonal form of vitamin D, induces differentiation of HL-60 human promyelocytes into monocyte-like cells in vitro. We assessed the relative activity of 30 analogs of 1,25-dihydroxyvitamin D3 in inducing development of monocytic markers in HL-60 cells. The three differe...

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Veröffentlicht in:	The Journal of biological chemistry 1987-10, Vol.262 (29), p.14164-14171
Hauptverfasser:	Ostrem, V K, Lau, W F, Lee, S H, Perlman, K, Prahl, J, Schnoes, H K, DeLuca, H F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcitriol - analogs & derivatives Calcitriol - pharmacology Carboxylesterase Carboxylic Ester Hydrolases - metabolism Cell Differentiation - drug effects Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Fundamental and applied biological sciences. Psychology Humans Leukemia, Myeloid, Acute Molecular and cellular biology Monocytes - cytology Phagocytosis - drug effects Structure-Activity Relationship
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