Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model
The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic® on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast pr...
Gespeichert in:
| Veröffentlicht in: | Current eye research 1984, Vol.3 (4), p.619-623 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 623 |
|---|---|
| container_issue | 4 |
| container_start_page | 619 |
| container_title | Current eye research |
| container_volume | 3 |
| creator | Sunalp, Murad Wiedemann, Peter Sorgente, Nino Ryan, Stephen J. |
| description | The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic® on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast proliferation and prevented the formation of membranes as well as did triamcinolone, whereas methotrexate and Viroptic® had no beneficial effect in this model of PVR. |
| doi_str_mv | 10.3109/02713688409003063 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_81026803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81026803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c345t-42e31cc09fc08ef90133bd09ee834d71c78310b096c3daefa2b2bdf84fdc401e3</originalsourceid><addsrcrecordid>eNp9UF1LHDEUDWKxq_YH9KGQB_Ft2puPnZ1BX4qoLQi-6PM0k9y4WTKTbZLR7r83y26FUvDpwvni3EPIZwZfBYP2G_AFE3XTSGgBBNTigMyYrKHiHPghmW35qgjER3Kc0gpgC8gjclRLPgfWzsiva2tR50SDpXqTQw5_nKYmTk8FGuk6Bu8sRpXdM9JnlyOGiNmNYa3yckPdSPMSaVR97zLV6H2BViXQFfMQDPpT8sEqn_DT_p6Qx5vrh6sf1d397c-r73eVFnKeK8lRMK2htRoatC0wIXoDLWIjpFkwvWjKxz20tRZGoVW8572xjbRGS2AoTsj5LrdU_j1hyt3g0raQGjFMqWsY8LoBUYRsJ9QxpBTRduvoBhU3HYNuu2r336rF82UfPvUDmjfHfsbCn-15lbTyNqpRu_Qma-clT86L7HInc6MNcVAvIXrTZbXxIf71iPdaXPxjX6LyealVxG4VpjiWed_54RW-9KXu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81026803</pqid></control><display><type>article</type><title>Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Access via Taylor & Francis</source><creator>Sunalp, Murad ; Wiedemann, Peter ; Sorgente, Nino ; Ryan, Stephen J.</creator><creatorcontrib>Sunalp, Murad ; Wiedemann, Peter ; Sorgente, Nino ; Ryan, Stephen J.</creatorcontrib><description>The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic® on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast proliferation and prevented the formation of membranes as well as did triamcinolone, whereas methotrexate and Viroptic® had no beneficial effect in this model of PVR.</description><identifier>ISSN: 0271-3683</identifier><identifier>EISSN: 1460-2202</identifier><identifier>DOI: 10.3109/02713688409003063</identifier><identifier>PMID: 6425019</identifier><identifier>CODEN: CEYRDM</identifier><language>eng</language><publisher>Lisse: Informa UK Ltd</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Disease Models, Animal ; Doxorubicin - therapeutic use ; Eye ; Eye Diseases - drug therapy ; Female ; Fibroblasts - drug effects ; Fluorouracil - therapeutic use ; Male ; Medical sciences ; Methotrexate - therapeutic use ; Pharmacology. Drug treatments ; Rabbits ; Retinal Detachment - drug therapy ; Retinal Diseases - drug therapy ; Triamcinolone - therapeutic use ; Trifluridine - therapeutic use ; Vitreous Body - drug effects</subject><ispartof>Current eye research, 1984, Vol.3 (4), p.619-623</ispartof><rights>1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-42e31cc09fc08ef90133bd09ee834d71c78310b096c3daefa2b2bdf84fdc401e3</citedby><cites>FETCH-LOGICAL-c345t-42e31cc09fc08ef90133bd09ee834d71c78310b096c3daefa2b2bdf84fdc401e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02713688409003063$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02713688409003063$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9513645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6425019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sunalp, Murad</creatorcontrib><creatorcontrib>Wiedemann, Peter</creatorcontrib><creatorcontrib>Sorgente, Nino</creatorcontrib><creatorcontrib>Ryan, Stephen J.</creatorcontrib><title>Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model</title><title>Current eye research</title><addtitle>Curr Eye Res</addtitle><description>The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic® on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast proliferation and prevented the formation of membranes as well as did triamcinolone, whereas methotrexate and Viroptic® had no beneficial effect in this model of PVR.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Doxorubicin - therapeutic use</subject><subject>Eye</subject><subject>Eye Diseases - drug therapy</subject><subject>Female</subject><subject>Fibroblasts - drug effects</subject><subject>Fluorouracil - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methotrexate - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Retinal Detachment - drug therapy</subject><subject>Retinal Diseases - drug therapy</subject><subject>Triamcinolone - therapeutic use</subject><subject>Trifluridine - therapeutic use</subject><subject>Vitreous Body - drug effects</subject><issn>0271-3683</issn><issn>1460-2202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UF1LHDEUDWKxq_YH9KGQB_Ft2puPnZ1BX4qoLQi-6PM0k9y4WTKTbZLR7r83y26FUvDpwvni3EPIZwZfBYP2G_AFE3XTSGgBBNTigMyYrKHiHPghmW35qgjER3Kc0gpgC8gjclRLPgfWzsiva2tR50SDpXqTQw5_nKYmTk8FGuk6Bu8sRpXdM9JnlyOGiNmNYa3yckPdSPMSaVR97zLV6H2BViXQFfMQDPpT8sEqn_DT_p6Qx5vrh6sf1d397c-r73eVFnKeK8lRMK2htRoatC0wIXoDLWIjpFkwvWjKxz20tRZGoVW8572xjbRGS2AoTsj5LrdU_j1hyt3g0raQGjFMqWsY8LoBUYRsJ9QxpBTRduvoBhU3HYNuu2r336rF82UfPvUDmjfHfsbCn-15lbTyNqpRu_Qma-clT86L7HInc6MNcVAvIXrTZbXxIf71iPdaXPxjX6LyealVxG4VpjiWed_54RW-9KXu</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Sunalp, Murad</creator><creator>Wiedemann, Peter</creator><creator>Sorgente, Nino</creator><creator>Ryan, Stephen J.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Swets & Zeitlinger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model</title><author>Sunalp, Murad ; Wiedemann, Peter ; Sorgente, Nino ; Ryan, Stephen J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-42e31cc09fc08ef90133bd09ee834d71c78310b096c3daefa2b2bdf84fdc401e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Doxorubicin - therapeutic use</topic><topic>Eye</topic><topic>Eye Diseases - drug therapy</topic><topic>Female</topic><topic>Fibroblasts - drug effects</topic><topic>Fluorouracil - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methotrexate - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Retinal Detachment - drug therapy</topic><topic>Retinal Diseases - drug therapy</topic><topic>Triamcinolone - therapeutic use</topic><topic>Trifluridine - therapeutic use</topic><topic>Vitreous Body - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sunalp, Murad</creatorcontrib><creatorcontrib>Wiedemann, Peter</creatorcontrib><creatorcontrib>Sorgente, Nino</creatorcontrib><creatorcontrib>Ryan, Stephen J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sunalp, Murad</au><au>Wiedemann, Peter</au><au>Sorgente, Nino</au><au>Ryan, Stephen J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model</atitle><jtitle>Current eye research</jtitle><addtitle>Curr Eye Res</addtitle><date>1984</date><risdate>1984</risdate><volume>3</volume><issue>4</issue><spage>619</spage><epage>623</epage><pages>619-623</pages><issn>0271-3683</issn><eissn>1460-2202</eissn><coden>CEYRDM</coden><abstract>The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic® on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast proliferation and prevented the formation of membranes as well as did triamcinolone, whereas methotrexate and Viroptic® had no beneficial effect in this model of PVR.</abstract><cop>Lisse</cop><pub>Informa UK Ltd</pub><pmid>6425019</pmid><doi>10.3109/02713688409003063</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-3683 |
| ispartof | Current eye research, 1984, Vol.3 (4), p.619-623 |
| issn | 0271-3683 1460-2202 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81026803 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Disease Models, Animal Doxorubicin - therapeutic use Eye Eye Diseases - drug therapy Female Fibroblasts - drug effects Fluorouracil - therapeutic use Male Medical sciences Methotrexate - therapeutic use Pharmacology. Drug treatments Rabbits Retinal Detachment - drug therapy Retinal Diseases - drug therapy Triamcinolone - therapeutic use Trifluridine - therapeutic use Vitreous Body - drug effects |
| title | Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T20%3A17%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20cytotoxic%20drugs%20on%20proliferative%20vitreoretinopathy%20in%20the%20rabbit%20cell%20injection%20model&rft.jtitle=Current%20eye%20research&rft.au=Sunalp,%20Murad&rft.date=1984&rft.volume=3&rft.issue=4&rft.spage=619&rft.epage=623&rft.pages=619-623&rft.issn=0271-3683&rft.eissn=1460-2202&rft.coden=CEYRDM&rft_id=info:doi/10.3109/02713688409003063&rft_dat=%3Cproquest_infor%3E81026803%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81026803&rft_id=info:pmid/6425019&rfr_iscdi=true |