Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model

The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic® on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast pr...

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Veröffentlicht in:	Current eye research 1984, Vol.3 (4), p.619-623
Hauptverfasser:	Sunalp, Murad, Wiedemann, Peter, Sorgente, Nino, Ryan, Stephen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Disease Models, Animal Doxorubicin - therapeutic use Eye Eye Diseases - drug therapy Female Fibroblasts - drug effects Fluorouracil - therapeutic use Male Medical sciences Methotrexate - therapeutic use Pharmacology. Drug treatments Rabbits Retinal Detachment - drug therapy Retinal Diseases - drug therapy Triamcinolone - therapeutic use Trifluridine - therapeutic use Vitreous Body - drug effects
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Beschreibung
Zusammenfassung:	The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic® on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast proliferation and prevented the formation of membranes as well as did triamcinolone, whereas methotrexate and Viroptic® had no beneficial effect in this model of PVR.
ISSN:	0271-3683 1460-2202
DOI:	10.3109/02713688409003063