Cyclic nucleotides and seizures in a hereditary model of epilepsy
The high seizure susceptibility in epilieptic fowl is due to an autosomal recessive mutation. Cyclic AMP and cyclic GMP concentrations were determined in brains from two day old epileptic chicks (homozygotes) during an inter-ictal period as well as during and following a seizure evoked by stroboscop...
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| Veröffentlicht in: | Brain research bulletin 1984, Vol.12 (1), p.137-142 |
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| creator | Crawford, K.D.A. Johnson, D.D. Hickie, R.A. Crawford, R.D. |
| description | The high seizure susceptibility in epilieptic fowl is due to an autosomal recessive mutation. Cyclic AMP and cyclic GMP concentrations were determined in brains from two day old epileptic chicks (homozygotes) during an inter-ictal period as well as during and following a seizure evoked by stroboscopic stimulation. The data were compared to values obtained from non-epileptic carrier chicks (heterozygotes) sacrificed in an unstimulated state or subjected to the seizure evoking stimulus. During the inter-ictal state in epileptics no abnormalities were found in cyclic nucleotide concentrations indicating that the high seizure susceptibility is not related to abnormalities of these nucleotides. Although seizure activity in epileptics was associated with reduced cyclic AMP in the optic lobes this also occurred in carrier chicks subjected to the seizure evoking stimulus. The only significant changes in cyclic GMP levels, occurring as a result of seizures in epileptics, were an increase in cyclic GMP in the cerebral hemispheres during the seizure and a decrease in the optic lobes during the postictal period. |
| doi_str_mv | 10.1016/0361-9230(84)90226-0 |
| format | Article |
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Cyclic AMP and cyclic GMP concentrations were determined in brains from two day old epileptic chicks (homozygotes) during an inter-ictal period as well as during and following a seizure evoked by stroboscopic stimulation. The data were compared to values obtained from non-epileptic carrier chicks (heterozygotes) sacrificed in an unstimulated state or subjected to the seizure evoking stimulus. During the inter-ictal state in epileptics no abnormalities were found in cyclic nucleotide concentrations indicating that the high seizure susceptibility is not related to abnormalities of these nucleotides. Although seizure activity in epileptics was associated with reduced cyclic AMP in the optic lobes this also occurred in carrier chicks subjected to the seizure evoking stimulus. The only significant changes in cyclic GMP levels, occurring as a result of seizures in epileptics, were an increase in cyclic GMP in the cerebral hemispheres during the seizure and a decrease in the optic lobes during the postictal period.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(84)90226-0</identifier><identifier>PMID: 6324961</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Brain - metabolism ; Chickens ; Cyclic AMP - metabolism ; Cyclic GMP - metabolism ; Cyclic nucleotides ; Disease Models, Animal ; Epilepsy ; Epilepsy - genetics ; Epilepsy - metabolism ; Heterozygote ; Homozygote ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Seizures - metabolism ; Tissue Distribution</subject><ispartof>Brain research bulletin, 1984, Vol.12 (1), p.137-142</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-51ceb3c3c9ec8d60b189de64086f0dd4b97b4311500df085e2978867ca7aaebe3</citedby><cites>FETCH-LOGICAL-c417t-51ceb3c3c9ec8d60b189de64086f0dd4b97b4311500df085e2978867ca7aaebe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0361-9230(84)90226-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8988234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6324961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crawford, K.D.A.</creatorcontrib><creatorcontrib>Johnson, D.D.</creatorcontrib><creatorcontrib>Hickie, R.A.</creatorcontrib><creatorcontrib>Crawford, R.D.</creatorcontrib><title>Cyclic nucleotides and seizures in a hereditary model of epilepsy</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>The high seizure susceptibility in epilieptic fowl is due to an autosomal recessive mutation. Cyclic AMP and cyclic GMP concentrations were determined in brains from two day old epileptic chicks (homozygotes) during an inter-ictal period as well as during and following a seizure evoked by stroboscopic stimulation. The data were compared to values obtained from non-epileptic carrier chicks (heterozygotes) sacrificed in an unstimulated state or subjected to the seizure evoking stimulus. During the inter-ictal state in epileptics no abnormalities were found in cyclic nucleotide concentrations indicating that the high seizure susceptibility is not related to abnormalities of these nucleotides. Although seizure activity in epileptics was associated with reduced cyclic AMP in the optic lobes this also occurred in carrier chicks subjected to the seizure evoking stimulus. The only significant changes in cyclic GMP levels, occurring as a result of seizures in epileptics, were an increase in cyclic GMP in the cerebral hemispheres during the seizure and a decrease in the optic lobes during the postictal period.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Chickens</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic GMP - metabolism</subject><subject>Cyclic nucleotides</subject><subject>Disease Models, Animal</subject><subject>Epilepsy</subject><subject>Epilepsy - genetics</subject><subject>Epilepsy - metabolism</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Seizures - metabolism</subject><subject>Tissue Distribution</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQQEVo2G43-Qct-FBKenAy-rAsXQJhSZvAQi7JWcjSmKp47a1kBza_vtqs2WN7GmbmzTDzCPlM4ZoClTfAJS0143ClxHcNjMkSzsiSqpqXrBb1B7I8IR_Jp5R-A4BUlVyQheRMaEmX5G69d11wRT-5DocxeEyF7X2RMLxNMSehL2zxCyP6MNq4L7aDx64Y2gJ3ocNd2l-Q89Z2CS_nuCIvP-6f1w_l5unn4_puUzpB67GsqMOGO-40OuUlNFRpj1KAki14LxpdN4JTWgH4FlSFTNdKydrZ2lpskK_It-PeXRz-TJhGsw3JYdfZHocpGUWBiSo_-z-Qcs0YA5pBcQRdHFKK2JpdDNv8pKFgDorNwZ85-DNKmHfFubQiX-b9U7NFfxqaneb-17lvk7NdG23vQjphSivFuMjY7RHDLO01YDTJBexdFh3RjcYP4d93_AWCmZak</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Crawford, K.D.A.</creator><creator>Johnson, D.D.</creator><creator>Hickie, R.A.</creator><creator>Crawford, R.D.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Cyclic nucleotides and seizures in a hereditary model of epilepsy</title><author>Crawford, K.D.A. ; Johnson, D.D. ; Hickie, R.A. ; Crawford, R.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-51ceb3c3c9ec8d60b189de64086f0dd4b97b4311500df085e2978867ca7aaebe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Chickens</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic GMP - metabolism</topic><topic>Cyclic nucleotides</topic><topic>Disease Models, Animal</topic><topic>Epilepsy</topic><topic>Epilepsy - genetics</topic><topic>Epilepsy - metabolism</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Seizures - metabolism</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crawford, K.D.A.</creatorcontrib><creatorcontrib>Johnson, D.D.</creatorcontrib><creatorcontrib>Hickie, R.A.</creatorcontrib><creatorcontrib>Crawford, R.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crawford, K.D.A.</au><au>Johnson, D.D.</au><au>Hickie, R.A.</au><au>Crawford, R.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclic nucleotides and seizures in a hereditary model of epilepsy</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1984</date><risdate>1984</risdate><volume>12</volume><issue>1</issue><spage>137</spage><epage>142</epage><pages>137-142</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>The high seizure susceptibility in epilieptic fowl is due to an autosomal recessive mutation. Cyclic AMP and cyclic GMP concentrations were determined in brains from two day old epileptic chicks (homozygotes) during an inter-ictal period as well as during and following a seizure evoked by stroboscopic stimulation. The data were compared to values obtained from non-epileptic carrier chicks (heterozygotes) sacrificed in an unstimulated state or subjected to the seizure evoking stimulus. During the inter-ictal state in epileptics no abnormalities were found in cyclic nucleotide concentrations indicating that the high seizure susceptibility is not related to abnormalities of these nucleotides. Although seizure activity in epileptics was associated with reduced cyclic AMP in the optic lobes this also occurred in carrier chicks subjected to the seizure evoking stimulus. The only significant changes in cyclic GMP levels, occurring as a result of seizures in epileptics, were an increase in cyclic GMP in the cerebral hemispheres during the seizure and a decrease in the optic lobes during the postictal period.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6324961</pmid><doi>10.1016/0361-9230(84)90226-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 1984, Vol.12 (1), p.137-142 |
| issn | 0361-9230 1873-2747 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Brain - metabolism Chickens Cyclic AMP - metabolism Cyclic GMP - metabolism Cyclic nucleotides Disease Models, Animal Epilepsy Epilepsy - genetics Epilepsy - metabolism Heterozygote Homozygote Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Seizures - metabolism Tissue Distribution |
| title | Cyclic nucleotides and seizures in a hereditary model of epilepsy |
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