Effect of iodide, methimazole, and thyroxine on thyroidal accumulation of radioiodide in immature domestic fowl [Gallus domesticus]
Accumulation of radioiodide by the thyroids of individual domestic fowl was measured with the technique described by T. F. Davison, J. G. Rowell, and J. Rea, [1981) J. Endocrinol. 89, 371-378). Radioiodide uptake was markedly decreased in birds given an excess of iodide in the drinking water (60 mg...
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| Veröffentlicht in: | Gen. Comp. Endocrinol.; (United States) 1984-01, Vol.53 (1), p.86-89 |
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| description | Accumulation of radioiodide by the thyroids of individual domestic fowl was measured with the technique described by T. F. Davison, J. G. Rowell, and J. Rea, [1981) J. Endocrinol. 89, 371-378). Radioiodide uptake was markedly decreased in birds given an excess of iodide in the drinking water (60 mg KI/liter) or injections of thyroxine (T4: 5 X 50 micrograms T4/kg body wt), in agreement with published findings. Treatment with a goitrogen (250 mg methimazole/liter drinking water) decreased 125I uptake for at least 8 days but thereafter uptake increased and this was accompanied by gross thyroidal enlargement. The results indicate that the thyroid partly compensates for goitrogenic inhibition. |
| doi_str_mv | 10.1016/0016-6480(84)90227-2 |
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F. Davison, J. G. Rowell, and J. Rea, [1981) J. Endocrinol. 89, 371-378). Radioiodide uptake was markedly decreased in birds given an excess of iodide in the drinking water (60 mg KI/liter) or injections of thyroxine (T4: 5 X 50 micrograms T4/kg body wt), in agreement with published findings. Treatment with a goitrogen (250 mg methimazole/liter drinking water) decreased 125I uptake for at least 8 days but thereafter uptake increased and this was accompanied by gross thyroidal enlargement. The results indicate that the thyroid partly compensates for goitrogenic inhibition.</description><identifier>ISSN: 0016-6480</identifier><identifier>EISSN: 1095-6840</identifier><identifier>DOI: 10.1016/0016-6480(84)90227-2</identifier><identifier>PMID: 6714654</identifier><language>eng</language><publisher>United States</publisher><subject>560152 -- Radiation Effects on Animals-- Animals ; AMINO ACIDS ; ANIMALS ; AZOLES ; BETA DECAY RADIOISOTOPES ; BIOLOGICAL ACCUMULATION ; BIOLOGICAL EFFECTS ; BIRDS ; BODY ; CARBOXYLIC ACIDS ; CHICKENS ; Chickens - metabolism ; DAYS LIVING RADIOISOTOPES ; DRINKING WATER ; ELECTRON CAPTURE RADIOISOTOPES ; ENDOCRINE GLANDS ; Female ; FOWL ; GLANDS ; HETEROCYCLIC COMPOUNDS ; HORMONES ; HYDROGEN COMPOUNDS ; IMIDAZOLES ; INTERMEDIATE MASS NUCLEI ; Iodides - pharmacology ; IODINE 125 ; IODINE ISOTOPES ; Iodine Radioisotopes - metabolism ; ISOTOPES ; Kinetics ; Liver - drug effects ; Male ; Methimazole - pharmacology ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; ORGANIC IODINE COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; OXYGEN COMPOUNDS ; PEPTIDE HORMONES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOISOTOPES ; Radionuclide Imaging ; THYROID ; Thyroid Gland - diagnostic imaging ; Thyroid Gland - drug effects ; Thyroid Gland - metabolism ; THYROID HORMONES ; THYROXINE ; Thyroxine - blood ; Thyroxine - pharmacology ; VERTEBRATES ; WATER 560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)</subject><ispartof>Gen. Comp. 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Endocrinol.; (United States)</title><addtitle>Gen Comp Endocrinol</addtitle><description>Accumulation of radioiodide by the thyroids of individual domestic fowl was measured with the technique described by T. F. Davison, J. G. Rowell, and J. Rea, [1981) J. Endocrinol. 89, 371-378). Radioiodide uptake was markedly decreased in birds given an excess of iodide in the drinking water (60 mg KI/liter) or injections of thyroxine (T4: 5 X 50 micrograms T4/kg body wt), in agreement with published findings. Treatment with a goitrogen (250 mg methimazole/liter drinking water) decreased 125I uptake for at least 8 days but thereafter uptake increased and this was accompanied by gross thyroidal enlargement. The results indicate that the thyroid partly compensates for goitrogenic inhibition.</description><subject>560152 -- Radiation Effects on Animals-- Animals</subject><subject>AMINO ACIDS</subject><subject>ANIMALS</subject><subject>AZOLES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BIOLOGICAL ACCUMULATION</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIRDS</subject><subject>BODY</subject><subject>CARBOXYLIC ACIDS</subject><subject>CHICKENS</subject><subject>Chickens - metabolism</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DRINKING WATER</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>ENDOCRINE GLANDS</subject><subject>Female</subject><subject>FOWL</subject><subject>GLANDS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HORMONES</subject><subject>HYDROGEN COMPOUNDS</subject><subject>IMIDAZOLES</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>Iodides - pharmacology</subject><subject>IODINE 125</subject><subject>IODINE ISOTOPES</subject><subject>Iodine Radioisotopes - metabolism</subject><subject>ISOTOPES</subject><subject>Kinetics</subject><subject>Liver - drug effects</subject><subject>Male</subject><subject>Methimazole - pharmacology</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>ORGANIC IODINE COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>OXYGEN COMPOUNDS</subject><subject>PEPTIDE HORMONES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOISOTOPES</subject><subject>Radionuclide Imaging</subject><subject>THYROID</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - metabolism</subject><subject>THYROID HORMONES</subject><subject>THYROXINE</subject><subject>Thyroxine - blood</subject><subject>Thyroxine - pharmacology</subject><subject>VERTEBRATES</subject><subject>WATER 560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMlKBDEQhoMoOi4vIArBgyjYmj2Zo4iOguBBPYk0mSxOJN3RTjcuV1_cSA9eqqiqr_4qfgD2MDrFCIszVEIlmEJHih1PESGyIitggtGUV0IxtAom_8gG2Mz5FSHEqcDrYF1IzARnE_Bz6b0zPUwehmSDdSewcf0iNPo7xVLo1sJ-8dWlz9A6mNqxCFZHqI0ZmiHqPpR22e-0DWkUgaGFoWl0P3QO2tS43AcDffqI8GmmYxzyf3fIz9tgzeuY3c4yb4HHq8uHi-vq9m52c3F-W3msWF9RL6nnhs-5xcwSKqygc2bFFDNCCaKWe0Mwx0Ii6ZgmnBHGEdJ87p2XU0G3wMGom8rhOpvQO7MwqW2LAbWQjAj2Bx2O0FuX3ofyYt2EbFyMunVpyLXCiFCl_sD9JTjMG2frt66Y1n3VS2vLfHece51q_dKFXD_eKyaZwpL-AvEahM0</recordid><startdate>198401</startdate><enddate>198401</enddate><creator>Davison, T.F</creator><creator>Rea, J</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198401</creationdate><title>Effect of iodide, methimazole, and thyroxine on thyroidal accumulation of radioiodide in immature domestic fowl [Gallus domesticus]</title><author>Davison, T.F ; Rea, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f184t-3f73f5c5b5d14d236d63b4d691423203d5fc21516707e4a25424500a5bfef7963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>560152 -- Radiation Effects on Animals-- Animals</topic><topic>AMINO ACIDS</topic><topic>ANIMALS</topic><topic>AZOLES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BIOLOGICAL ACCUMULATION</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIRDS</topic><topic>BODY</topic><topic>CARBOXYLIC ACIDS</topic><topic>CHICKENS</topic><topic>Chickens - metabolism</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DRINKING WATER</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>ENDOCRINE GLANDS</topic><topic>Female</topic><topic>FOWL</topic><topic>GLANDS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HORMONES</topic><topic>HYDROGEN COMPOUNDS</topic><topic>IMIDAZOLES</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>Iodides - pharmacology</topic><topic>IODINE 125</topic><topic>IODINE ISOTOPES</topic><topic>Iodine Radioisotopes - metabolism</topic><topic>ISOTOPES</topic><topic>Kinetics</topic><topic>Liver - drug effects</topic><topic>Male</topic><topic>Methimazole - pharmacology</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>ORGANIC IODINE COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>OXYGEN COMPOUNDS</topic><topic>PEPTIDE HORMONES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOISOTOPES</topic><topic>Radionuclide Imaging</topic><topic>THYROID</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - metabolism</topic><topic>THYROID HORMONES</topic><topic>THYROXINE</topic><topic>Thyroxine - blood</topic><topic>Thyroxine - pharmacology</topic><topic>VERTEBRATES</topic><topic>WATER 560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davison, T.F</creatorcontrib><creatorcontrib>Rea, J</creatorcontrib><creatorcontrib>Houghton Poultry Research Station, Huntingdon, Cambridgeshire, England</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Gen. Comp. Endocrinol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davison, T.F</au><au>Rea, J</au><aucorp>Houghton Poultry Research Station, Huntingdon, Cambridgeshire, England</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of iodide, methimazole, and thyroxine on thyroidal accumulation of radioiodide in immature domestic fowl [Gallus domesticus]</atitle><jtitle>Gen. Comp. Endocrinol.; (United States)</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>1984-01</date><risdate>1984</risdate><volume>53</volume><issue>1</issue><spage>86</spage><epage>89</epage><pages>86-89</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>Accumulation of radioiodide by the thyroids of individual domestic fowl was measured with the technique described by T. F. Davison, J. G. Rowell, and J. Rea, [1981) J. Endocrinol. 89, 371-378). Radioiodide uptake was markedly decreased in birds given an excess of iodide in the drinking water (60 mg KI/liter) or injections of thyroxine (T4: 5 X 50 micrograms T4/kg body wt), in agreement with published findings. Treatment with a goitrogen (250 mg methimazole/liter drinking water) decreased 125I uptake for at least 8 days but thereafter uptake increased and this was accompanied by gross thyroidal enlargement. The results indicate that the thyroid partly compensates for goitrogenic inhibition.</abstract><cop>United States</cop><pmid>6714654</pmid><doi>10.1016/0016-6480(84)90227-2</doi><tpages>4</tpages></addata></record> |
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| subjects | 560152 -- Radiation Effects on Animals-- Animals AMINO ACIDS ANIMALS AZOLES BETA DECAY RADIOISOTOPES BIOLOGICAL ACCUMULATION BIOLOGICAL EFFECTS BIRDS BODY CARBOXYLIC ACIDS CHICKENS Chickens - metabolism DAYS LIVING RADIOISOTOPES DRINKING WATER ELECTRON CAPTURE RADIOISOTOPES ENDOCRINE GLANDS Female FOWL GLANDS HETEROCYCLIC COMPOUNDS HORMONES HYDROGEN COMPOUNDS IMIDAZOLES INTERMEDIATE MASS NUCLEI Iodides - pharmacology IODINE 125 IODINE ISOTOPES Iodine Radioisotopes - metabolism ISOTOPES Kinetics Liver - drug effects Male Methimazole - pharmacology NUCLEI ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC IODINE COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS OXYGEN COMPOUNDS PEPTIDE HORMONES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES Radionuclide Imaging THYROID Thyroid Gland - diagnostic imaging Thyroid Gland - drug effects Thyroid Gland - metabolism THYROID HORMONES THYROXINE Thyroxine - blood Thyroxine - pharmacology VERTEBRATES WATER 560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987) |
| title | Effect of iodide, methimazole, and thyroxine on thyroidal accumulation of radioiodide in immature domestic fowl [Gallus domesticus] |
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