Supraspinal tonic influence on spinal reflexes and involvement in the effect of chlorpromazine
1. 1. Chlorpromazine (CPZ) depressed mono-(MSR) and polysynaptic reflexes in anesthetized rats. 2. 2. The MSR remained unaltered after spinal transection (C 1). After spinal transection, the inhibitory effect of CPZ on the MSR disappeared. After CPZ injection, spinal transection enhanced the MSR to...
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| Veröffentlicht in: | General pharmacology 1984, Vol.15 (2), p.155-158 |
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| container_title | General pharmacology |
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| creator | Hino, Masataka Ono, Hideki Fukuda, Hideomi |
| description | 1.
1. Chlorpromazine (CPZ) depressed mono-(MSR) and polysynaptic reflexes in anesthetized rats.
2.
2. The MSR remained unaltered after spinal transection (C
1). After spinal transection, the inhibitory effect of CPZ on the MSR disappeared. After CPZ injection, spinal transection enhanced the MSR to pre-drug level.
3.
3. Reserpine pretreatment abolished the inhibitory effect of CPZ on the MSR. Phenoxybenzamine inhibited the MSR and, when pre-injected, markedly attenuated the effect of CPZ on the MSR.
4.
4. These results suggest that in anesthetized rats, CPZ blocks the α-adrenoceptor-mediated facilitatory component of the spontaneous tonic influence on the MSR. |
| doi_str_mv | 10.1016/0306-3623(84)90100-9 |
| format | Article |
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1. Chlorpromazine (CPZ) depressed mono-(MSR) and polysynaptic reflexes in anesthetized rats.
2.
2. The MSR remained unaltered after spinal transection (C
1). After spinal transection, the inhibitory effect of CPZ on the MSR disappeared. After CPZ injection, spinal transection enhanced the MSR to pre-drug level.
3.
3. Reserpine pretreatment abolished the inhibitory effect of CPZ on the MSR. Phenoxybenzamine inhibited the MSR and, when pre-injected, markedly attenuated the effect of CPZ on the MSR.
4.
4. These results suggest that in anesthetized rats, CPZ blocks the α-adrenoceptor-mediated facilitatory component of the spontaneous tonic influence on the MSR.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(84)90100-9</identifier><identifier>PMID: 6143706</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Chlorpromazine - pharmacology ; Dose-Response Relationship, Drug ; Haloperidol - pharmacology ; Male ; Neurotransmitter Agents - physiology ; Phenoxybenzamine - pharmacology ; Rats ; Rats, Inbred Strains ; Reflex - drug effects ; Reflex - physiology ; Reflex, Monosynaptic - drug effects ; Reserpine - pharmacology ; Spinal Cord - drug effects ; Spinal Cord - physiology</subject><ispartof>General pharmacology, 1984, Vol.15 (2), p.155-158</ispartof><rights>1984</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-4af339d8f18a6b4e0d97866563d74394c11df95331dee2b9c0bbee9a7ebfaac43</citedby><cites>FETCH-LOGICAL-c423t-4af339d8f18a6b4e0d97866563d74394c11df95331dee2b9c0bbee9a7ebfaac43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6143706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hino, Masataka</creatorcontrib><creatorcontrib>Ono, Hideki</creatorcontrib><creatorcontrib>Fukuda, Hideomi</creatorcontrib><title>Supraspinal tonic influence on spinal reflexes and involvement in the effect of chlorpromazine</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. Chlorpromazine (CPZ) depressed mono-(MSR) and polysynaptic reflexes in anesthetized rats.
2.
2. The MSR remained unaltered after spinal transection (C
1). After spinal transection, the inhibitory effect of CPZ on the MSR disappeared. After CPZ injection, spinal transection enhanced the MSR to pre-drug level.
3.
3. Reserpine pretreatment abolished the inhibitory effect of CPZ on the MSR. Phenoxybenzamine inhibited the MSR and, when pre-injected, markedly attenuated the effect of CPZ on the MSR.
4.
4. These results suggest that in anesthetized rats, CPZ blocks the α-adrenoceptor-mediated facilitatory component of the spontaneous tonic influence on the MSR.</description><subject>Animals</subject><subject>Chlorpromazine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Haloperidol - pharmacology</subject><subject>Male</subject><subject>Neurotransmitter Agents - physiology</subject><subject>Phenoxybenzamine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reflex - drug effects</subject><subject>Reflex - physiology</subject><subject>Reflex, Monosynaptic - drug effects</subject><subject>Reserpine - pharmacology</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - physiology</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9r3DAQxUVpSTdpv0EKOpXk4GZkaWXrUighfwqBHNJeK2RpRBRsaSvZS5tPX213yTGnGXhv3mN-hJwy-MKAyQvgIBsuW37Wi3MFDKBRb8iK9Z1qABh7S1YvlvfkuJQnAGjXbXtEjiQTvAO5Ir8elk02ZROiGemcYrA0RD8uGC3SFOlByehH_IOFmuiqYZvGLU4Y57rT-REpeo92pslT-zimvMlpMs8h4gfyzpux4MfDPCE_r69-XN42d_c33y-_3TVWtHxuhPGcK9d71hs5CASnul7KteSuE1wJy5jzas05c4jtoCwMA6IyHQ7eGCv4Cfm8z63Nvxcss55CsTiOJmJaiu4ZtLxvu2oUe6PNqZT6lt7kMJn8VzPQO6x6x0zvmOle6P9Ytapnnw75yzChezk6cKz6172O9cltwKyLDTuGLuQKRrsUXi_4Bw-_iIo</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Hino, Masataka</creator><creator>Ono, Hideki</creator><creator>Fukuda, Hideomi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Supraspinal tonic influence on spinal reflexes and involvement in the effect of chlorpromazine</title><author>Hino, Masataka ; Ono, Hideki ; Fukuda, Hideomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-4af339d8f18a6b4e0d97866563d74394c11df95331dee2b9c0bbee9a7ebfaac43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Chlorpromazine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Haloperidol - pharmacology</topic><topic>Male</topic><topic>Neurotransmitter Agents - physiology</topic><topic>Phenoxybenzamine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reflex - drug effects</topic><topic>Reflex - physiology</topic><topic>Reflex, Monosynaptic - drug effects</topic><topic>Reserpine - pharmacology</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Hino, Masataka</creatorcontrib><creatorcontrib>Ono, Hideki</creatorcontrib><creatorcontrib>Fukuda, Hideomi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hino, Masataka</au><au>Ono, Hideki</au><au>Fukuda, Hideomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supraspinal tonic influence on spinal reflexes and involvement in the effect of chlorpromazine</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1984</date><risdate>1984</risdate><volume>15</volume><issue>2</issue><spage>155</spage><epage>158</epage><pages>155-158</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><abstract>1.
1. Chlorpromazine (CPZ) depressed mono-(MSR) and polysynaptic reflexes in anesthetized rats.
2.
2. The MSR remained unaltered after spinal transection (C
1). After spinal transection, the inhibitory effect of CPZ on the MSR disappeared. After CPZ injection, spinal transection enhanced the MSR to pre-drug level.
3.
3. Reserpine pretreatment abolished the inhibitory effect of CPZ on the MSR. Phenoxybenzamine inhibited the MSR and, when pre-injected, markedly attenuated the effect of CPZ on the MSR.
4.
4. These results suggest that in anesthetized rats, CPZ blocks the α-adrenoceptor-mediated facilitatory component of the spontaneous tonic influence on the MSR.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>6143706</pmid><doi>10.1016/0306-3623(84)90100-9</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-3623 |
| ispartof | General pharmacology, 1984, Vol.15 (2), p.155-158 |
| issn | 0306-3623 1879-0011 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81023827 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Chlorpromazine - pharmacology Dose-Response Relationship, Drug Haloperidol - pharmacology Male Neurotransmitter Agents - physiology Phenoxybenzamine - pharmacology Rats Rats, Inbred Strains Reflex - drug effects Reflex - physiology Reflex, Monosynaptic - drug effects Reserpine - pharmacology Spinal Cord - drug effects Spinal Cord - physiology |
| title | Supraspinal tonic influence on spinal reflexes and involvement in the effect of chlorpromazine |
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