Peripheral nerve reconnection: Inhibition of early degenerative processes through the use of a novel fluid medium
Two pharmacologic manipulations were applied to injured nerves in the rat to minimize the secondary damage that accompanies peripheral nerve transection. It is known that calcium influx into the nerve is responsible for some of the processes that have been termed Wallerian degeneration. These disrup...
Gespeichert in:
| Veröffentlicht in: | Experimental neurology 1984-05, Vol.84 (2), p.396-408 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 408 |
|---|---|
| container_issue | 2 |
| container_start_page | 396 |
| container_title | Experimental neurology |
| container_volume | 84 |
| creator | de Medinaceli, Luis Church, Allen C. |
| description | Two pharmacologic manipulations were applied to injured nerves in the rat to minimize the secondary damage that accompanies peripheral nerve transection. It is known that calcium influx into the nerve is responsible for some of the processes that have been termed Wallerian degeneration. These disruptive effects of high intracellular calcium were retarded by chlorpromazine, a potent inhibitor of calmodulin. Our results suggested a new method for reducing posttraumatic neural disruption and supported our hypothesis regarding the involvement of calmodulin or some other Ca
2+ binding protein in Wallerian degeneration. The second part of this report describes changes observed at the tips of a severed nerve and their prevention through the use of polyvinyl alcohol. Finally, we showed that neither substance produced functional deficits when injected directly into the sciatic nerve of rats and could thus be used in animal experimentation. |
| doi_str_mv | 10.1016/0014-4886(84)90236-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81022664</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>001448868490236X</els_id><sourcerecordid>81022664</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-4793d5e6f650ba5ac9c7c4881b85ff60b401b9b425abbfd73203314cec3ac0d13</originalsourceid><addsrcrecordid>eNp9kUuLFDEQgIMo67j6DxRykEUPvVYenUl7EJbFx8LCelDYW0jSlZ1IT3o26R7Yf2_aGeboqQL1VaXqK0LeMrhkwNQnACYbqbX6oOXHDrhQzf0zsmLQQcOlgOdkdUJeklel_AGATvL1GTlTHJjQYkUef2KOuw1mO9CEeY80ox9TQj_FMX2mN2kTXVzedAwUbR6eaI8PWFk7xYrv8uixFCx02uRxftjUiHQuuPCWpnGPAw3DHHu6xT7O29fkRbBDwTfHeE5-f_v66_pHc3v3_eb66rbxQqupketO9C2qoFpwtrW-82tfV2FOtyEocBKY65zkrXUu9GvBQQgmPXphPfRMnJOLQ9864eOMZTLbWDwOg004zsVoBpwrJSsoD6DPYykZg9nluLX5yTAwi2mzaDSLRqOl-Wfa3Neyd8f-s6ubnYqOamv-_TFvi7dDyDb5WE6Y1ppzvfz-5YBhdbGPmE3xEZOvruolJtOP8f9z_AUBXZv8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81022664</pqid></control><display><type>article</type><title>Peripheral nerve reconnection: Inhibition of early degenerative processes through the use of a novel fluid medium</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>de Medinaceli, Luis ; Church, Allen C.</creator><creatorcontrib>de Medinaceli, Luis ; Church, Allen C.</creatorcontrib><description>Two pharmacologic manipulations were applied to injured nerves in the rat to minimize the secondary damage that accompanies peripheral nerve transection. It is known that calcium influx into the nerve is responsible for some of the processes that have been termed Wallerian degeneration. These disruptive effects of high intracellular calcium were retarded by chlorpromazine, a potent inhibitor of calmodulin. Our results suggested a new method for reducing posttraumatic neural disruption and supported our hypothesis regarding the involvement of calmodulin or some other Ca
2+ binding protein in Wallerian degeneration. The second part of this report describes changes observed at the tips of a severed nerve and their prevention through the use of polyvinyl alcohol. Finally, we showed that neither substance produced functional deficits when injected directly into the sciatic nerve of rats and could thus be used in animal experimentation.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/0014-4886(84)90236-X</identifier><identifier>PMID: 6201383</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Axonal Transport - drug effects ; Biological and medical sciences ; Calcium - physiology ; Chlorpromazine - pharmacology ; Culture Media - pharmacology ; Drug Combinations ; Fundamental and applied biological sciences. Psychology ; Isolated neuron and nerve. Neuroglia ; Nerve Degeneration - drug effects ; Polyvinyl Alcohol - pharmacology ; Rats ; Rats, Inbred Strains ; Sciatic Nerve - physiology ; Vertebrates: nervous system and sense organs ; Wallerian Degeneration - drug effects</subject><ispartof>Experimental neurology, 1984-05, Vol.84 (2), p.396-408</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-4793d5e6f650ba5ac9c7c4881b85ff60b401b9b425abbfd73203314cec3ac0d13</citedby><cites>FETCH-LOGICAL-c386t-4793d5e6f650ba5ac9c7c4881b85ff60b401b9b425abbfd73203314cec3ac0d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-4886(84)90236-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8882284$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6201383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Medinaceli, Luis</creatorcontrib><creatorcontrib>Church, Allen C.</creatorcontrib><title>Peripheral nerve reconnection: Inhibition of early degenerative processes through the use of a novel fluid medium</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>Two pharmacologic manipulations were applied to injured nerves in the rat to minimize the secondary damage that accompanies peripheral nerve transection. It is known that calcium influx into the nerve is responsible for some of the processes that have been termed Wallerian degeneration. These disruptive effects of high intracellular calcium were retarded by chlorpromazine, a potent inhibitor of calmodulin. Our results suggested a new method for reducing posttraumatic neural disruption and supported our hypothesis regarding the involvement of calmodulin or some other Ca
2+ binding protein in Wallerian degeneration. The second part of this report describes changes observed at the tips of a severed nerve and their prevention through the use of polyvinyl alcohol. Finally, we showed that neither substance produced functional deficits when injected directly into the sciatic nerve of rats and could thus be used in animal experimentation.</description><subject>Animals</subject><subject>Axonal Transport - drug effects</subject><subject>Biological and medical sciences</subject><subject>Calcium - physiology</subject><subject>Chlorpromazine - pharmacology</subject><subject>Culture Media - pharmacology</subject><subject>Drug Combinations</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Nerve Degeneration - drug effects</subject><subject>Polyvinyl Alcohol - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sciatic Nerve - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Wallerian Degeneration - drug effects</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuLFDEQgIMo67j6DxRykEUPvVYenUl7EJbFx8LCelDYW0jSlZ1IT3o26R7Yf2_aGeboqQL1VaXqK0LeMrhkwNQnACYbqbX6oOXHDrhQzf0zsmLQQcOlgOdkdUJeklel_AGATvL1GTlTHJjQYkUef2KOuw1mO9CEeY80ox9TQj_FMX2mN2kTXVzedAwUbR6eaI8PWFk7xYrv8uixFCx02uRxftjUiHQuuPCWpnGPAw3DHHu6xT7O29fkRbBDwTfHeE5-f_v66_pHc3v3_eb66rbxQqupketO9C2qoFpwtrW-82tfV2FOtyEocBKY65zkrXUu9GvBQQgmPXphPfRMnJOLQ9864eOMZTLbWDwOg004zsVoBpwrJSsoD6DPYykZg9nluLX5yTAwi2mzaDSLRqOl-Wfa3Neyd8f-s6ubnYqOamv-_TFvi7dDyDb5WE6Y1ppzvfz-5YBhdbGPmE3xEZOvruolJtOP8f9z_AUBXZv8</recordid><startdate>198405</startdate><enddate>198405</enddate><creator>de Medinaceli, Luis</creator><creator>Church, Allen C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198405</creationdate><title>Peripheral nerve reconnection: Inhibition of early degenerative processes through the use of a novel fluid medium</title><author>de Medinaceli, Luis ; Church, Allen C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-4793d5e6f650ba5ac9c7c4881b85ff60b401b9b425abbfd73203314cec3ac0d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Axonal Transport - drug effects</topic><topic>Biological and medical sciences</topic><topic>Calcium - physiology</topic><topic>Chlorpromazine - pharmacology</topic><topic>Culture Media - pharmacology</topic><topic>Drug Combinations</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Nerve Degeneration - drug effects</topic><topic>Polyvinyl Alcohol - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sciatic Nerve - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Wallerian Degeneration - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Medinaceli, Luis</creatorcontrib><creatorcontrib>Church, Allen C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Medinaceli, Luis</au><au>Church, Allen C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral nerve reconnection: Inhibition of early degenerative processes through the use of a novel fluid medium</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1984-05</date><risdate>1984</risdate><volume>84</volume><issue>2</issue><spage>396</spage><epage>408</epage><pages>396-408</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Two pharmacologic manipulations were applied to injured nerves in the rat to minimize the secondary damage that accompanies peripheral nerve transection. It is known that calcium influx into the nerve is responsible for some of the processes that have been termed Wallerian degeneration. These disruptive effects of high intracellular calcium were retarded by chlorpromazine, a potent inhibitor of calmodulin. Our results suggested a new method for reducing posttraumatic neural disruption and supported our hypothesis regarding the involvement of calmodulin or some other Ca
2+ binding protein in Wallerian degeneration. The second part of this report describes changes observed at the tips of a severed nerve and their prevention through the use of polyvinyl alcohol. Finally, we showed that neither substance produced functional deficits when injected directly into the sciatic nerve of rats and could thus be used in animal experimentation.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>6201383</pmid><doi>10.1016/0014-4886(84)90236-X</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4886 |
| ispartof | Experimental neurology, 1984-05, Vol.84 (2), p.396-408 |
| issn | 0014-4886 1090-2430 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81022664 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Axonal Transport - drug effects Biological and medical sciences Calcium - physiology Chlorpromazine - pharmacology Culture Media - pharmacology Drug Combinations Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia Nerve Degeneration - drug effects Polyvinyl Alcohol - pharmacology Rats Rats, Inbred Strains Sciatic Nerve - physiology Vertebrates: nervous system and sense organs Wallerian Degeneration - drug effects |
| title | Peripheral nerve reconnection: Inhibition of early degenerative processes through the use of a novel fluid medium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T01%3A45%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Peripheral%20nerve%20reconnection:%20Inhibition%20of%20early%20degenerative%20processes%20through%20the%20use%20of%20a%20novel%20fluid%20medium&rft.jtitle=Experimental%20neurology&rft.au=de%20Medinaceli,%20Luis&rft.date=1984-05&rft.volume=84&rft.issue=2&rft.spage=396&rft.epage=408&rft.pages=396-408&rft.issn=0014-4886&rft.eissn=1090-2430&rft.coden=EXNEAC&rft_id=info:doi/10.1016/0014-4886(84)90236-X&rft_dat=%3Cproquest_cross%3E81022664%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81022664&rft_id=info:pmid/6201383&rft_els_id=001448868490236X&rfr_iscdi=true |