Abolition of the behavioral effects of cholecystokinin following bilateral radiofrequency lesions of the parvocellular subdivision of the nucleus tractus solitarius
Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of...
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| Veröffentlicht in: | Brain research 1984-03, Vol.295 (2), p.289-299 |
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| creator | Crawley, J.N. Schwaber, J.S. |
| description | Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Selective destruction of the parvocellular subdivisions of the nucleus tractus solitarius (NTS) blocked the effects of acute doses of CCK on exploratory behaviors. Sham lesions and lesions destroying only the remaining regions of the NTS or the vagal motor nulei had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. These findings delineate the first central site along the ascending sensory pathway which appears to mediate the satiety-related behavioral effects of CCK. |
| doi_str_mv | 10.1016/0006-8993(84)90978-8 |
| format | Article |
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Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Selective destruction of the parvocellular subdivisions of the nucleus tractus solitarius (NTS) blocked the effects of acute doses of CCK on exploratory behaviors. Sham lesions and lesions destroying only the remaining regions of the NTS or the vagal motor nulei had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. These findings delineate the first central site along the ascending sensory pathway which appears to mediate the satiety-related behavioral effects of CCK.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(84)90978-8</identifier><identifier>PMID: 6713189</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Behavior, Animal - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; cholecystokinin ; Cholecystokinin - pharmacology ; exploratory behavior ; Fundamental and applied biological sciences. Psychology ; Male ; Medulla Oblongata - physiology ; Motor Activity - drug effects ; Neural Pathways - physiology ; nucleus tractus solitarius ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Radio Waves ; Rats ; Rats, Inbred Strains ; vagus nerve</subject><ispartof>Brain research, 1984-03, Vol.295 (2), p.289-299</ispartof><rights>1984 Elsevier Science Publishers B.V., Amsterdam</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-8831732d210129f0f4b9da84d2552fbb3d9ba204f90cbfb65221d254865db203</citedby><cites>FETCH-LOGICAL-c483t-8831732d210129f0f4b9da84d2552fbb3d9ba204f90cbfb65221d254865db203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899384909788$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9615894$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6713189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crawley, J.N.</creatorcontrib><creatorcontrib>Schwaber, J.S.</creatorcontrib><title>Abolition of the behavioral effects of cholecystokinin following bilateral radiofrequency lesions of the parvocellular subdivision of the nucleus tractus solitarius</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Selective destruction of the parvocellular subdivisions of the nucleus tractus solitarius (NTS) blocked the effects of acute doses of CCK on exploratory behaviors. Sham lesions and lesions destroying only the remaining regions of the NTS or the vagal motor nulei had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. These findings delineate the first central site along the ascending sensory pathway which appears to mediate the satiety-related behavioral effects of CCK.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>cholecystokinin</subject><subject>Cholecystokinin - pharmacology</subject><subject>exploratory behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medulla Oblongata - physiology</subject><subject>Motor Activity - drug effects</subject><subject>Neural Pathways - physiology</subject><subject>nucleus tractus solitarius</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Radio Waves</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>vagus nerve</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctuFDEQRS0ECpPAH4DUC4Rg0cGv7rY3SFFECFKkbLK3_GQMnvbg6h40_5MPxc0MI1awKln31HVVXYReEXxJMOk_YIz7VkjJ3gn-XmI5iFY8QSsiBtr2lOOnaHVCnqNzgG_1yZjEZ-isHwgjQq7Q45XJKU4xj00OzbT2jfFrvYu56NT4ELydYFHsOidv9zDl73GMYxNySvlnHL82JiY9-QUv2sUciv8x-9Hum-Sh2sIf360uu2x9SnPSpYHZuLiL8NfH42yTn6GZirZTrbAMpkuc4QV6FnQC__JYL9DDzaeH69v27v7zl-uru9ZywaZWCEYGRh2t56Ey4MCNdFpwR7uOBmOYk0ZTzIPE1gTTd5SSqnHRd85QzC7Q24PttuS6A0xqE2GZWI8-z6AEwZQMgvwXJEz0PeYLyA-gLRmg-KC2JW502SuC1RKiWhJSS0JKcPU7RCVq2-uj_2w23p2ajqlV_c1R12B1CkWPNsIJkz3phOQV-3jAfL3ZLvqiwMYajXex1FyVy_Hfc_wCVSy8_A</recordid><startdate>19840319</startdate><enddate>19840319</enddate><creator>Crawley, J.N.</creator><creator>Schwaber, J.S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19840319</creationdate><title>Abolition of the behavioral effects of cholecystokinin following bilateral radiofrequency lesions of the parvocellular subdivision of the nucleus tractus solitarius</title><author>Crawley, J.N. ; Schwaber, J.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-8831732d210129f0f4b9da84d2552fbb3d9ba204f90cbfb65221d254865db203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>cholecystokinin</topic><topic>Cholecystokinin - pharmacology</topic><topic>exploratory behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medulla Oblongata - physiology</topic><topic>Motor Activity - drug effects</topic><topic>Neural Pathways - physiology</topic><topic>nucleus tractus solitarius</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Radio Waves</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>vagus nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crawley, J.N.</creatorcontrib><creatorcontrib>Schwaber, J.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crawley, J.N.</au><au>Schwaber, J.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abolition of the behavioral effects of cholecystokinin following bilateral radiofrequency lesions of the parvocellular subdivision of the nucleus tractus solitarius</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1984-03-19</date><risdate>1984</risdate><volume>295</volume><issue>2</issue><spage>289</spage><epage>299</epage><pages>289-299</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Selective destruction of the parvocellular subdivisions of the nucleus tractus solitarius (NTS) blocked the effects of acute doses of CCK on exploratory behaviors. Sham lesions and lesions destroying only the remaining regions of the NTS or the vagal motor nulei had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. 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| ispartof | Brain research, 1984-03, Vol.295 (2), p.289-299 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences cholecystokinin Cholecystokinin - pharmacology exploratory behavior Fundamental and applied biological sciences. Psychology Male Medulla Oblongata - physiology Motor Activity - drug effects Neural Pathways - physiology nucleus tractus solitarius Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Radio Waves Rats Rats, Inbred Strains vagus nerve |
| title | Abolition of the behavioral effects of cholecystokinin following bilateral radiofrequency lesions of the parvocellular subdivision of the nucleus tractus solitarius |
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