Chronic cocaine administration depletes tyrosine hydroxylase immunoreactivity in the meso-limbic dopamine system in rat brain: quantitative light microscopic studies

Chronic administration of cocaine (10 mg/kg, IP, every 12 hours for 10 consecutive days) produced a large decrease in tyrosine hydroxylase staining axons and terminal boutons in the frontal cortex and nucleus accumbens in rats. This treatment also produced a depletion of tyrosine hydroxylase immunor...

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Veröffentlicht in:	Brain research bulletin 1987-07, Vol.19 (1), p.39-45
Hauptverfasser:	TRULSON, M. E, JOE, J. C, BABB, S, RAESE, J. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cocaine - administration & dosage Cocaine - pharmacology Frontal Lobe - drug effects Frontal Lobe - enzymology Immunohistochemistry Injections, Intraperitoneal Limbic System - drug effects Limbic System - enzymology Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychodysleptics: hallucinogen Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Tegmentum Mesencephali - drug effects Tegmentum Mesencephali - enzymology Time Factors Tyrosine 3-Monooxygenase - metabolism
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