Concentrations of Immunoreactive Thyrotropin-Releasing Hormone in Spinal Cord of Patients with Amyotrophic Lateral Sclerosis
Concentrations of immunoreactive thyrotropin-releasing hormone (ir-TRH) were measured by specific radioimmunoassay in the spinal cord of six patients with amyotrophic lateral sclerosis (ALS) and seven with non- neurological diseases. Ir-TRH concentrations were the highest in the anterior horn, compa...
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| Veröffentlicht in: | The American journal of the medical sciences 1984-04, Vol.287 (2), p.34-36 |
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| creator | Mitsuma, Terunori Nogimori, Tsuyoshi Adachi, Koshin Mukoyama, Masakuni Ando, Kazuya |
| description | Concentrations of immunoreactive thyrotropin-releasing hormone (ir-TRH) were measured by specific radioimmunoassay in the spinal cord of six patients with amyotrophic lateral sclerosis (ALS) and seven with non- neurological diseases. Ir-TRH concentrations were the highest in the anterior horn, compared with other areas of the spinal cord, both in nonneurological diseases and ALS. Ir-TRH concentrations in the anterior horn of ALS were significantly lower than in nonneurological diseases, but were the same in both groups in other parts of the spinal cord (e.g. posterior horn, frontal part, lateral and central part, posterior part). Ir-TRH concentrations in rat spinal cords were stable for up to seven hours when spinal cord was stored after death at 4°C or 22°C. An elution profile of methanol-extracted human spinal cord on Sephandex G-10 column was identical to that of synthetic TRH. The cell population in the anterior horn in ALS was decreased markedly. The findings suggest that TRH is present in the human spinal cord and its decreased concentrations in the anterior horn of ALS may be due to a decrease in the cell population. |
| doi_str_mv | 10.1097/00000441-198403000-00007 |
| format | Article |
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Ir-TRH concentrations were the highest in the anterior horn, compared with other areas of the spinal cord, both in nonneurological diseases and ALS. Ir-TRH concentrations in the anterior horn of ALS were significantly lower than in nonneurological diseases, but were the same in both groups in other parts of the spinal cord (e.g. posterior horn, frontal part, lateral and central part, posterior part). Ir-TRH concentrations in rat spinal cords were stable for up to seven hours when spinal cord was stored after death at 4°C or 22°C. An elution profile of methanol-extracted human spinal cord on Sephandex G-10 column was identical to that of synthetic TRH. The cell population in the anterior horn in ALS was decreased markedly. The findings suggest that TRH is present in the human spinal cord and its decreased concentrations in the anterior horn of ALS may be due to a decrease in the cell population.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/00000441-198403000-00007</identifier><identifier>PMID: 6424472</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - metabolism ; Amyotrophic Lateral Sclerosis - pathology ; Animals ; Biological and medical sciences ; Cell Count ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Humans ; Immunoreactive thyrotropin-releasing hormone ; Male ; Medical sciences ; Middle Aged ; Neurology ; Radioimmunoassay ; Rats ; Spinal Cord - analysis ; Spinal Cord - pathology ; Thyrotropin - blood ; Thyrotropin-Releasing Hormone - analysis ; Thyroxine - blood</subject><ispartof>The American journal of the medical sciences, 1984-04, Vol.287 (2), p.34-36</ispartof><rights>1984 Southern Society for Clinical Investigation</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-35cb62c2bb39fb3e307ec8ccc6c97944747ead950f9ad4919ec464301c62cd7f3</citedby><cites>FETCH-LOGICAL-c398t-35cb62c2bb39fb3e307ec8ccc6c97944747ead950f9ad4919ec464301c62cd7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8957351$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6424472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitsuma, Terunori</creatorcontrib><creatorcontrib>Nogimori, Tsuyoshi</creatorcontrib><creatorcontrib>Adachi, Koshin</creatorcontrib><creatorcontrib>Mukoyama, Masakuni</creatorcontrib><creatorcontrib>Ando, Kazuya</creatorcontrib><title>Concentrations of Immunoreactive Thyrotropin-Releasing Hormone in Spinal Cord of Patients with Amyotrophic Lateral Sclerosis</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Concentrations of immunoreactive thyrotropin-releasing hormone (ir-TRH) were measured by specific radioimmunoassay in the spinal cord of six patients with amyotrophic lateral sclerosis (ALS) and seven with non- neurological diseases. Ir-TRH concentrations were the highest in the anterior horn, compared with other areas of the spinal cord, both in nonneurological diseases and ALS. Ir-TRH concentrations in the anterior horn of ALS were significantly lower than in nonneurological diseases, but were the same in both groups in other parts of the spinal cord (e.g. posterior horn, frontal part, lateral and central part, posterior part). Ir-TRH concentrations in rat spinal cords were stable for up to seven hours when spinal cord was stored after death at 4°C or 22°C. An elution profile of methanol-extracted human spinal cord on Sephandex G-10 column was identical to that of synthetic TRH. The cell population in the anterior horn in ALS was decreased markedly. The findings suggest that TRH is present in the human spinal cord and its decreased concentrations in the anterior horn of ALS may be due to a decrease in the cell population.</description><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - metabolism</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoreactive thyrotropin-releasing hormone</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Spinal Cord - analysis</subject><subject>Spinal Cord - pathology</subject><subject>Thyrotropin - blood</subject><subject>Thyrotropin-Releasing Hormone - analysis</subject><subject>Thyroxine - blood</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUFuPEyEUJkazdld_ggkPxrdZYWCG4XFt3EvSRLOXZ8KcOWMxM1CBrmnij5dua1_lhfDdzuEjhHJ2yZlWn9n-SMkrrjvJRHlUe0S9IgveiK6qtWavyaJAdaXbWr8l5yn9ZIzXHRdn5KyVtZSqXpA_y-ABfY42u-ATDSO9m-etDxEtZPeM9HG9iyHHsHG-uscJbXL-B70NcQ4eqfP0oTB2ossQh739e0kqgYn-dnlNr-bdi3ntgK5sxliUDzBhDMmld-TNaKeE74_3BXm6_vq4vK1W327ullerCoTuciUa6Nsa6r4XeuwFCqYQOgBoQStd_iEV2kE3bNR2kJprBNlKwTgU16BGcUE-HXI3MfzaYspmdglwmqzHsE2m44wrxdoi7A5CKPuliKPZRDfbuDOcmX3x5l_x5lT8C6SK9cNxxrafcTgZj00X_uORtwnsNEbrwaWTrNONEg0vsi8HGZY-nh1Gk6DUCTi4iJDNENz_d_kLmlihsA</recordid><startdate>198404</startdate><enddate>198404</enddate><creator>Mitsuma, Terunori</creator><creator>Nogimori, Tsuyoshi</creator><creator>Adachi, Koshin</creator><creator>Mukoyama, Masakuni</creator><creator>Ando, Kazuya</creator><general>Elsevier Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198404</creationdate><title>Concentrations of Immunoreactive Thyrotropin-Releasing Hormone in Spinal Cord of Patients with Amyotrophic Lateral Sclerosis</title><author>Mitsuma, Terunori ; Nogimori, Tsuyoshi ; Adachi, Koshin ; Mukoyama, Masakuni ; Ando, Kazuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-35cb62c2bb39fb3e307ec8ccc6c97944747ead950f9ad4919ec464301c62cd7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - metabolism</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoreactive thyrotropin-releasing hormone</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Spinal Cord - analysis</topic><topic>Spinal Cord - pathology</topic><topic>Thyrotropin - blood</topic><topic>Thyrotropin-Releasing Hormone - analysis</topic><topic>Thyroxine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitsuma, Terunori</creatorcontrib><creatorcontrib>Nogimori, Tsuyoshi</creatorcontrib><creatorcontrib>Adachi, Koshin</creatorcontrib><creatorcontrib>Mukoyama, Masakuni</creatorcontrib><creatorcontrib>Ando, Kazuya</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitsuma, Terunori</au><au>Nogimori, Tsuyoshi</au><au>Adachi, Koshin</au><au>Mukoyama, Masakuni</au><au>Ando, Kazuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concentrations of Immunoreactive Thyrotropin-Releasing Hormone in Spinal Cord of Patients with Amyotrophic Lateral Sclerosis</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>1984-04</date><risdate>1984</risdate><volume>287</volume><issue>2</issue><spage>34</spage><epage>36</epage><pages>34-36</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>Concentrations of immunoreactive thyrotropin-releasing hormone (ir-TRH) were measured by specific radioimmunoassay in the spinal cord of six patients with amyotrophic lateral sclerosis (ALS) and seven with non- neurological diseases. Ir-TRH concentrations were the highest in the anterior horn, compared with other areas of the spinal cord, both in nonneurological diseases and ALS. Ir-TRH concentrations in the anterior horn of ALS were significantly lower than in nonneurological diseases, but were the same in both groups in other parts of the spinal cord (e.g. posterior horn, frontal part, lateral and central part, posterior part). Ir-TRH concentrations in rat spinal cords were stable for up to seven hours when spinal cord was stored after death at 4°C or 22°C. An elution profile of methanol-extracted human spinal cord on Sephandex G-10 column was identical to that of synthetic TRH. The cell population in the anterior horn in ALS was decreased markedly. The findings suggest that TRH is present in the human spinal cord and its decreased concentrations in the anterior horn of ALS may be due to a decrease in the cell population.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>6424472</pmid><doi>10.1097/00000441-198403000-00007</doi><tpages>3</tpages></addata></record> |
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| subjects | Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Biological and medical sciences Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Immunoreactive thyrotropin-releasing hormone Male Medical sciences Middle Aged Neurology Radioimmunoassay Rats Spinal Cord - analysis Spinal Cord - pathology Thyrotropin - blood Thyrotropin-Releasing Hormone - analysis Thyroxine - blood |
| title | Concentrations of Immunoreactive Thyrotropin-Releasing Hormone in Spinal Cord of Patients with Amyotrophic Lateral Sclerosis |
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