High malformation rates and decreased mortality in infants of diabetic mothers managed after the first trimester of pregnancy (1956–1978)
Over a period of 23 years we accumulated data on 182 pregnant juvenile diabetic subjects during pregnancy, labor, and delivery. Diabetic subjects were evaluated generally after the first trimester of pregnancy. Data examined included diabetic class, maternal complications of pregnancy and infant mor...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1984-04, Vol.148 (8), p.1111-1118 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 148 |
| creator | Ballard, Jeanne L. Holroyde, Jane Tsang, Reginald C. Chan, Gary Sutherland, James M. Knowles, Harvey C. |
| description | Over a period of 23 years we accumulated data on 182 pregnant juvenile diabetic subjects during pregnancy, labor, and delivery. Diabetic subjects were evaluated generally after the first trimester of pregnancy. Data examined included diabetic class, maternal complications of pregnancy and infant morbidity and mortality. Data were analyzed in two periods-before and after 1970. In the second period, maternal polyhydramnios and acidosis rates improved, neonatal problems of homeostasis did not change significantly, and combined fetal and neonatal losses fell from 34.7% to 16.4%. The neonatal malformation rate, however, increased from 1.4% to 16.8% and was not influenced by maternal age ondiabetic class. |
| doi_str_mv | 10.1016/0002-9378(84)90637-9 |
| format | Article |
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Diabetic subjects were evaluated generally after the first trimester of pregnancy. Data examined included diabetic class, maternal complications of pregnancy and infant morbidity and mortality. Data were analyzed in two periods-before and after 1970. In the second period, maternal polyhydramnios and acidosis rates improved, neonatal problems of homeostasis did not change significantly, and combined fetal and neonatal losses fell from 34.7% to 16.4%. 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Diabetic subjects were evaluated generally after the first trimester of pregnancy. Data examined included diabetic class, maternal complications of pregnancy and infant morbidity and mortality. Data were analyzed in two periods-before and after 1970. In the second period, maternal polyhydramnios and acidosis rates improved, neonatal problems of homeostasis did not change significantly, and combined fetal and neonatal losses fell from 34.7% to 16.4%. The neonatal malformation rate, however, increased from 1.4% to 16.8% and was not influenced by maternal age ondiabetic class.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetal Death - epidemiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant Mortality</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Ohio</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - physiopathology</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy. Fetus. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant Mortality</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Ohio</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - physiopathology</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy. Fetus. Placenta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ballard, Jeanne L.</creatorcontrib><creatorcontrib>Holroyde, Jane</creatorcontrib><creatorcontrib>Tsang, Reginald C.</creatorcontrib><creatorcontrib>Chan, Gary</creatorcontrib><creatorcontrib>Sutherland, James M.</creatorcontrib><creatorcontrib>Knowles, Harvey C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ballard, Jeanne L.</au><au>Holroyde, Jane</au><au>Tsang, Reginald C.</au><au>Chan, Gary</au><au>Sutherland, James M.</au><au>Knowles, Harvey C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High malformation rates and decreased mortality in infants of diabetic mothers managed after the first trimester of pregnancy (1956–1978)</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1984-04-15</date><risdate>1984</risdate><volume>148</volume><issue>8</issue><spage>1111</spage><epage>1118</epage><pages>1111-1118</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Over a period of 23 years we accumulated data on 182 pregnant juvenile diabetic subjects during pregnancy, labor, and delivery. Diabetic subjects were evaluated generally after the first trimester of pregnancy. Data examined included diabetic class, maternal complications of pregnancy and infant morbidity and mortality. Data were analyzed in two periods-before and after 1970. In the second period, maternal polyhydramnios and acidosis rates improved, neonatal problems of homeostasis did not change significantly, and combined fetal and neonatal losses fell from 34.7% to 16.4%. The neonatal malformation rate, however, increased from 1.4% to 16.8% and was not influenced by maternal age ondiabetic class.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>6711647</pmid><doi>10.1016/0002-9378(84)90637-9</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1984-04, Vol.148 (8), p.1111-1118 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Biological and medical sciences Congenital Abnormalities - epidemiology Diabetes Mellitus, Type 1 - physiopathology Diseases of mother, fetus and pregnancy Female Fetal Death - epidemiology Gynecology. Andrology. Obstetrics Humans Infant Mortality Infant, Newborn Medical sciences Ohio Pregnancy Pregnancy in Diabetics - physiopathology Pregnancy Trimester, First Pregnancy. Fetus. Placenta |
| title | High malformation rates and decreased mortality in infants of diabetic mothers managed after the first trimester of pregnancy (1956–1978) |
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