Leucyl-leucine methyl ester treatment of donor cells permits establishment of immunocompetent parent----F1 chimeras that are selectively tolerant of host alloantigens

Treatment of murine lymphocytes with L-leucyl-L-leucine methyl ester (Leu-Leu-OMe) selectively removes natural killer cells, cytotoxic T lymphocyte precursors, and the capacity to cause lethal graft-vs-host disease, whereas bone marrow stem cell function and alloantigen-induced L3T4+ T helper functi...

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Veröffentlicht in:	The Journal of immunology (1950) 1987-10, Vol.139 (7), p.2137-2142
Hauptverfasser:	Thiele, DL, Calomeni, JA, Lipsky, PE
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences B-Lymphocytes - immunology Bone Marrow - immunology Bone Marrow Transplantation Crosses, Genetic Dipeptides - pharmacology Exact sciences and technology H-2 Antigens - immunology Immune Tolerance Immunocompetence - drug effects Lymphocyte Activation Mice Mice, Inbred C57BL - immunology Mice, Inbred DBA - immunology Other techniques and industries Radiation Chimera Spleen - immunology Spleen - transplantation T-Lymphocytes, Cytotoxic - immunology
Online-Zugang:	Volltext
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