Adrenergic and Serotonergic Receptor-Blocking Potencies of Terazosin, a New Antihypertensive Agent, as Assessed by Radioligand Binding Assay

To assess the antihypertensive effect of terazosin, 2 [4- (tetrahydro-2-furanyl) carbonyl-l-piperazinyl] -6, 7-dimethoxy-4-quinazolinamine hydrochloride dihydrate, the inhibitory potency of terazosin on 3H-prazosin, 3H-p-aminoclonidine, 3H-dihydroalprenolol (3H-DHA), 3H-serotonin and 3H-ketanserin b...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1987/04/25, Vol.35(4), pp.1629-1632
Hauptverfasser:	NAGATOMO, TAKAFUMI, TAJIRI, AKIRA, NAKAMURA, TAKASHI, HOKIBARA, REI, TANAKA, YUKO, AONO, JUNICHIRO, TSUCHIHASHI, HIROSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - pharmacology alpha-adrenoceptor Animals antagonist Antihypertensive agents aorta Biological and medical sciences brain Brain Chemistry - drug effects Cardiovascular system dog Dogs In Vitro Techniques Male Medical sciences Pharmacology. Drug treatments Prazosin - analogs & derivatives Prazosin - pharmacology Radioligand Assay radioligand binding assay Receptors, Adrenergic - drug effects Receptors, Serotonin - drug effects serotonergic receptor
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