Inhibition of deoxyhemoglobin S polymerization by glyceraldehyde

Glyceraldehyde reacts with hemoglobin S in the intact erythrocyte to reduce the degree of polymerization, thereby inhibiting sickling of the erythrocyte. Only five of the 24 amino groups per αβ dimer react with glyceraldehyde; the adducts are present as ketoamine structures, formed by Amadori rearra...

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Veröffentlicht in:	Analytical biochemistry 1984, Vol.136 (1), p.101-109
Hauptverfasser:	Acharya, A.Seetharama, Sussman, Leslie G., Jones, Wanda M., Manning, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Anemia, Sickle Cell - blood Biological and medical sciences Biopolymers Chemical Phenomena Chemistry Cyanates deoxyhemoglobin S erythrocytes Erythrocytes, Abnormal - metabolism Fundamental and applied biological sciences. Psychology glyceraldehyde Glyceraldehyde - pharmacology Hemoglobin, Sickle - metabolism Hemoproteins Humans In Vitro Techniques Metalloproteins Oxygen - blood Proteins
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