A soluble interleukin 2 receptor produced by a normal alloreactive human T cell clone binds interleukin 2 with low affinity

Several alloreactive human T cell clones derived from a rejected kidney graft were found to produce in their culture supernatants soluble interleukin 2 receptors (IL-2R) upon specific antigenic challenge (irradiated B cell line from the graft's donor). Among them, the 2B11, a high producer clon...

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Veröffentlicht in:	The Journal of immunology (1950) 1987-10, Vol.139 (7), p.2308-2316
Hauptverfasser:	Jacques, Y, Le Mauff, B, Boeffard, F, Godard, A, Soulillou, JP
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal - immunology Antigen-Antibody Reactions Antigens, Surface - metabolism Binding, Competitive Biological and medical sciences Cell Membrane - metabolism Clone Cells - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology interleukin 2 Interleukin-2 - metabolism lymphocytes T Lymphokines, interleukins ( function, expression) Radioimmunoassay Receptors, Immunologic - biosynthesis Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Receptors, Interleukin-2 Regulatory factors and their cellular receptors Solubility T-Lymphocytes - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 7
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