Translational control at the level of initiation between mRNAs for pre-existing proteins and a 22-kDa heat-shock protein of Chlamydomonas by small cytosolic RNAs
Small cytosolic RNAs (scRNAs) from human placenta inhibit translation of poly(A)‐rich RNA from Chlamydomonas in the wheat germ cell‐free system. The major exception is the mRNA for a nuclear‐coded 22‐kDa chloroplast heat‐shock protein whose translation is much less affected. Evidence is presented wh...
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| Veröffentlicht in: | European journal of biochemistry 1987, Vol.167 (3), p.501-505 |
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| container_title | European journal of biochemistry |
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| creator | Kloppstech, K Lorberboum, H De Groot, N Hochberg, A.A |
| description | Small cytosolic RNAs (scRNAs) from human placenta inhibit translation of poly(A)‐rich RNA from Chlamydomonas in the wheat germ cell‐free system. The major exception is the mRNA for a nuclear‐coded 22‐kDa chloroplast heat‐shock protein whose translation is much less affected. Evidence is presented which suggests that scRNAs do not directly interact with the mRNAs but with a factor of the wheat germ system instead. It has been found that run‐off translation of polyribosomes is not impaired by scRNAs whereas the formation of initiation complexes in vitro, again with the exception of those of the mRNA for the 22‐kDa heat‐shock protein, is heavily affected. From this evidence we conclude that scRNAs interfere with the action of one or more of the wheat germ initiation factors and that the translation of the mRNA for the 22‐kDa heat‐shock protein is much less dependent upon this (these) factor(s). |
| doi_str_mv | 10.1111/j.1432-1033.1987.tb13365.x |
| format | Article |
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The major exception is the mRNA for a nuclear‐coded 22‐kDa chloroplast heat‐shock protein whose translation is much less affected. Evidence is presented which suggests that scRNAs do not directly interact with the mRNAs but with a factor of the wheat germ system instead. It has been found that run‐off translation of polyribosomes is not impaired by scRNAs whereas the formation of initiation complexes in vitro, again with the exception of those of the mRNA for the 22‐kDa heat‐shock protein, is heavily affected. From this evidence we conclude that scRNAs interfere with the action of one or more of the wheat germ initiation factors and that the translation of the mRNA for the 22‐kDa heat‐shock protein is much less dependent upon this (these) factor(s).</description><identifier>ISSN: 0014-2956</identifier><identifier>EISSN: 1432-1033</identifier><identifier>DOI: 10.1111/j.1432-1033.1987.tb13365.x</identifier><identifier>PMID: 2443351</identifier><identifier>CODEN: EJBCAI</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Cell-Free System ; Chlamydomonas ; Chlamydomonas - genetics ; Chlamydomonas reinhardtii ; Fundamental and applied biological sciences. Psychology ; heat stress ; Heat-Shock Proteins - genetics ; Molecular and cellular biology ; Molecular genetics ; Molecular Weight ; Peptide Chain Initiation, Translational ; plant proteins ; Plants - metabolism ; Protein Biosynthesis ; ribosomes ; RNA ; RNA - genetics ; RNA, Messenger - genetics ; RNA, Small Cytoplasmic ; Translation. Translation factors. Protein processing ; Triticum - metabolism ; wheat germ</subject><ispartof>European journal of biochemistry, 1987, Vol.167 (3), p.501-505</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3691-b7bc81bcaf5fabd0d48bd6a3c9bcb55fee773f4b148e7228b18a8af258a428063</citedby><cites>FETCH-LOGICAL-c3691-b7bc81bcaf5fabd0d48bd6a3c9bcb55fee773f4b148e7228b18a8af258a428063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7442676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2443351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kloppstech, K</creatorcontrib><creatorcontrib>Lorberboum, H</creatorcontrib><creatorcontrib>De Groot, N</creatorcontrib><creatorcontrib>Hochberg, A.A</creatorcontrib><title>Translational control at the level of initiation between mRNAs for pre-existing proteins and a 22-kDa heat-shock protein of Chlamydomonas by small cytosolic RNAs</title><title>European journal of biochemistry</title><addtitle>Eur J Biochem</addtitle><description>Small cytosolic RNAs (scRNAs) from human placenta inhibit translation of poly(A)‐rich RNA from Chlamydomonas in the wheat germ cell‐free system. The major exception is the mRNA for a nuclear‐coded 22‐kDa chloroplast heat‐shock protein whose translation is much less affected. Evidence is presented which suggests that scRNAs do not directly interact with the mRNAs but with a factor of the wheat germ system instead. It has been found that run‐off translation of polyribosomes is not impaired by scRNAs whereas the formation of initiation complexes in vitro, again with the exception of those of the mRNA for the 22‐kDa heat‐shock protein, is heavily affected. From this evidence we conclude that scRNAs interfere with the action of one or more of the wheat germ initiation factors and that the translation of the mRNA for the 22‐kDa heat‐shock protein is much less dependent upon this (these) factor(s).</description><subject>Biological and medical sciences</subject><subject>Cell-Free System</subject><subject>Chlamydomonas</subject><subject>Chlamydomonas - genetics</subject><subject>Chlamydomonas reinhardtii</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>heat stress</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Weight</subject><subject>Peptide Chain Initiation, Translational</subject><subject>plant proteins</subject><subject>Plants - metabolism</subject><subject>Protein Biosynthesis</subject><subject>ribosomes</subject><subject>RNA</subject><subject>RNA - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Small Cytoplasmic</subject><subject>Translation. Translation factors. Protein processing</subject><subject>Triticum - metabolism</subject><subject>wheat germ</subject><issn>0014-2956</issn><issn>1432-1033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc1u1DAUhSMEKtPCIyAshLpL8E9-HDZVGVpAqkCi7dq6duyOp05cYg-dPA5visMMs0V4Y1nn3HuO9WXZG4ILks67dUFKRnOCGStIy5siSsJYXRXbJ9niID3NFhiTMqdtVT_PjkNYY4zrtm6OsiNaloxVZJH9uhlhCA6i9QM4pPwQR-8QRBRXGjn9UzvkDbKDjfaPCUkdH7UeUP_963lAxo_oYdS53toQ7XCXHj5qOwQEQ4cAUZrffwS00hDzsPLq_q9h3rpcOeinzvcpOyA5odCDSyWm6IN3VqE54kX2zIAL-uX-PsluLy9ulp_zq2-fvizPr3LF6pbkspGKE6nAVAZkh7uSy64GplqpZFUZrZuGmVKSkuuGUi4JBw6GVhxKynHNTrLT3d5U8MdGhyh6G5R2DgbtN0FwggnhjP7TmBKqmnGSjO93RjX6EEZtxMNoexgnQbCYQYq1mGmJmZaYQYo9SLFNw6_2KRvZ6-4wuieX9Ld7HYICZxJGZcPB1pQlrZv5V2c726N1evqPAuLy4sN1heeg17sNBryAuzGF3F7TJGCKa1K1nP0GqGjGoA</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Kloppstech, K</creator><creator>Lorberboum, H</creator><creator>De Groot, N</creator><creator>Hochberg, A.A</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Translational control at the level of initiation between mRNAs for pre-existing proteins and a 22-kDa heat-shock protein of Chlamydomonas by small cytosolic RNAs</title><author>Kloppstech, K ; Lorberboum, H ; De Groot, N ; Hochberg, A.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3691-b7bc81bcaf5fabd0d48bd6a3c9bcb55fee773f4b148e7228b18a8af258a428063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biological and medical sciences</topic><topic>Cell-Free System</topic><topic>Chlamydomonas</topic><topic>Chlamydomonas - genetics</topic><topic>Chlamydomonas reinhardtii</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>heat stress</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Weight</topic><topic>Peptide Chain Initiation, Translational</topic><topic>plant proteins</topic><topic>Plants - metabolism</topic><topic>Protein Biosynthesis</topic><topic>ribosomes</topic><topic>RNA</topic><topic>RNA - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Small Cytoplasmic</topic><topic>Translation. Translation factors. Protein processing</topic><topic>Triticum - metabolism</topic><topic>wheat germ</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kloppstech, K</creatorcontrib><creatorcontrib>Lorberboum, H</creatorcontrib><creatorcontrib>De Groot, N</creatorcontrib><creatorcontrib>Hochberg, A.A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kloppstech, K</au><au>Lorberboum, H</au><au>De Groot, N</au><au>Hochberg, A.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Translational control at the level of initiation between mRNAs for pre-existing proteins and a 22-kDa heat-shock protein of Chlamydomonas by small cytosolic RNAs</atitle><jtitle>European journal of biochemistry</jtitle><addtitle>Eur J Biochem</addtitle><date>1987</date><risdate>1987</risdate><volume>167</volume><issue>3</issue><spage>501</spage><epage>505</epage><pages>501-505</pages><issn>0014-2956</issn><eissn>1432-1033</eissn><coden>EJBCAI</coden><abstract>Small cytosolic RNAs (scRNAs) from human placenta inhibit translation of poly(A)‐rich RNA from Chlamydomonas in the wheat germ cell‐free system. The major exception is the mRNA for a nuclear‐coded 22‐kDa chloroplast heat‐shock protein whose translation is much less affected. Evidence is presented which suggests that scRNAs do not directly interact with the mRNAs but with a factor of the wheat germ system instead. It has been found that run‐off translation of polyribosomes is not impaired by scRNAs whereas the formation of initiation complexes in vitro, again with the exception of those of the mRNA for the 22‐kDa heat‐shock protein, is heavily affected. From this evidence we conclude that scRNAs interfere with the action of one or more of the wheat germ initiation factors and that the translation of the mRNA for the 22‐kDa heat‐shock protein is much less dependent upon this (these) factor(s).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2443351</pmid><doi>10.1111/j.1432-1033.1987.tb13365.x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0014-2956 |
| ispartof | European journal of biochemistry, 1987, Vol.167 (3), p.501-505 |
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| language | eng |
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| subjects | Biological and medical sciences Cell-Free System Chlamydomonas Chlamydomonas - genetics Chlamydomonas reinhardtii Fundamental and applied biological sciences. Psychology heat stress Heat-Shock Proteins - genetics Molecular and cellular biology Molecular genetics Molecular Weight Peptide Chain Initiation, Translational plant proteins Plants - metabolism Protein Biosynthesis ribosomes RNA RNA - genetics RNA, Messenger - genetics RNA, Small Cytoplasmic Translation. Translation factors. Protein processing Triticum - metabolism wheat germ |
| title | Translational control at the level of initiation between mRNAs for pre-existing proteins and a 22-kDa heat-shock protein of Chlamydomonas by small cytosolic RNAs |
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