Immunoglobulin G (IgG) subclasses and human disease
The isotypes of IgG, IgG 1, IgG 2, IgG 3, and IgG 4 were determined in immunoglobulin preparations and the effect on serum levels of treated patients. Serum IgG subclass deficiencies were recorded in different patient groups: (1) IgG 2–IgG 4 deficiency was associated with IgA deficiency. (2) IgG 2–I...
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| Veröffentlicht in: | The American journal of medicine 1984-03, Vol.76 (3), p.7-18 |
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| creator | Oxelius, Vivi-Anne |
| description | The isotypes of IgG, IgG
1, IgG
2, IgG
3, and IgG
4 were determined in immunoglobulin preparations and the effect on serum levels of treated patients. Serum IgG subclass deficiencies were recorded in different patient groups: (1) IgG
2–IgG
4 deficiency was associated with IgA deficiency. (2) IgG
2–IgG
4 deficiency was found in patients with ataxia telangiectasia. (3) Low IgG
2 levels were recorded in patients with SLE; one of these patients with recurrent pericarditis was treated with immunoglobulin with good results. (4) Low IgG
2 and/or low IgG
3 levels were found in patients with juvenile diabetes mellitus. (5) Mothers giving birth to severely group B streptococci infected infants showed low levels of IgG subclasses indicating that the newborns were IgG subclass deficient at birth. (6) In a prospective study of children with recurrent otitis media aged 12 and 32 months the IgG
2 levels were significantly reduced in the group with considerably high otitis proneness. In patients with IgG
2–IgG
4 deficiency, absence of antibodies to polysaccharide antigen teichoic acid and the protein antigen α-toxin of staphylococci was demonstrated. Imbalanced IgG subclass pattern with increased IgG
4 was recorded in patients with different diseases such as atopic diseases and also in combination with increased IgE, Henoch-Schönlein vasculitis, idiopathic pulmonary hemosiderosis, chronic mucocutaneous candidiasis, and in patients with Trichuris trichurea infection. |
| doi_str_mv | 10.1016/0002-9343(84)90314-0 |
| format | Article |
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1, IgG
2, IgG
3, and IgG
4 were determined in immunoglobulin preparations and the effect on serum levels of treated patients. Serum IgG subclass deficiencies were recorded in different patient groups: (1) IgG
2–IgG
4 deficiency was associated with IgA deficiency. (2) IgG
2–IgG
4 deficiency was found in patients with ataxia telangiectasia. (3) Low IgG
2 levels were recorded in patients with SLE; one of these patients with recurrent pericarditis was treated with immunoglobulin with good results. (4) Low IgG
2 and/or low IgG
3 levels were found in patients with juvenile diabetes mellitus. (5) Mothers giving birth to severely group B streptococci infected infants showed low levels of IgG subclasses indicating that the newborns were IgG subclass deficient at birth. (6) In a prospective study of children with recurrent otitis media aged 12 and 32 months the IgG
2 levels were significantly reduced in the group with considerably high otitis proneness. In patients with IgG
2–IgG
4 deficiency, absence of antibodies to polysaccharide antigen teichoic acid and the protein antigen α-toxin of staphylococci was demonstrated. Imbalanced IgG subclass pattern with increased IgG
4 was recorded in patients with different diseases such as atopic diseases and also in combination with increased IgE, Henoch-Schönlein vasculitis, idiopathic pulmonary hemosiderosis, chronic mucocutaneous candidiasis, and in patients with Trichuris trichurea infection.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(84)90314-0</identifier><identifier>PMID: 6369977</identifier><identifier>CODEN: AJMEAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Animals ; Antibodies, Heterophile - deficiency ; Ataxia Telangiectasia - complications ; Ataxia Telangiectasia - immunology ; Biological and medical sciences ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - immunology ; Female ; Humans ; Hypersensitivity - complications ; Hypersensitivity - immunology ; IgA Deficiency ; IgG Deficiency ; Immunization, Passive ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulin G - administration & dosage ; Immunoglobulin G - classification ; Immunoglobulinopathies ; Immunologic Deficiency Syndromes - complications ; Immunologic Deficiency Syndromes - immunology ; Immunologic Deficiency Syndromes - therapy ; Immunopathology ; Infant ; Infant, Newborn ; Lupus Erythematosus, Systemic - immunology ; Medical sciences ; Otitis Media - complications ; Otitis Media - immunology ; Rabbits ; Streptococcal Infections - complications ; Streptococcal Infections - immunology ; Streptococcus agalactiae - immunology</subject><ispartof>The American journal of medicine, 1984-03, Vol.76 (3), p.7-18</ispartof><rights>1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-2d3c436b7b0d5af1b7bdce7a6e00d238902ce110e4b7e511d4c16a0864ad35ed3</citedby><cites>FETCH-LOGICAL-c415t-2d3c436b7b0d5af1b7bdce7a6e00d238902ce110e4b7e511d4c16a0864ad35ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9343(84)90314-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9538758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6369977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oxelius, Vivi-Anne</creatorcontrib><title>Immunoglobulin G (IgG) subclasses and human disease</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>The isotypes of IgG, IgG
1, IgG
2, IgG
3, and IgG
4 were determined in immunoglobulin preparations and the effect on serum levels of treated patients. Serum IgG subclass deficiencies were recorded in different patient groups: (1) IgG
2–IgG
4 deficiency was associated with IgA deficiency. (2) IgG
2–IgG
4 deficiency was found in patients with ataxia telangiectasia. (3) Low IgG
2 levels were recorded in patients with SLE; one of these patients with recurrent pericarditis was treated with immunoglobulin with good results. (4) Low IgG
2 and/or low IgG
3 levels were found in patients with juvenile diabetes mellitus. (5) Mothers giving birth to severely group B streptococci infected infants showed low levels of IgG subclasses indicating that the newborns were IgG subclass deficient at birth. (6) In a prospective study of children with recurrent otitis media aged 12 and 32 months the IgG
2 levels were significantly reduced in the group with considerably high otitis proneness. In patients with IgG
2–IgG
4 deficiency, absence of antibodies to polysaccharide antigen teichoic acid and the protein antigen α-toxin of staphylococci was demonstrated. Imbalanced IgG subclass pattern with increased IgG
4 was recorded in patients with different diseases such as atopic diseases and also in combination with increased IgE, Henoch-Schönlein vasculitis, idiopathic pulmonary hemosiderosis, chronic mucocutaneous candidiasis, and in patients with Trichuris trichurea infection.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Antibodies, Heterophile - deficiency</subject><subject>Ataxia Telangiectasia - complications</subject><subject>Ataxia Telangiectasia - immunology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity - complications</subject><subject>Hypersensitivity - immunology</subject><subject>IgA Deficiency</subject><subject>IgG Deficiency</subject><subject>Immunization, Passive</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulin G - administration & dosage</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulinopathies</subject><subject>Immunologic Deficiency Syndromes - complications</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>Immunologic Deficiency Syndromes - therapy</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Medical sciences</subject><subject>Otitis Media - complications</subject><subject>Otitis Media - immunology</subject><subject>Rabbits</subject><subject>Streptococcal Infections - complications</subject><subject>Streptococcal Infections - immunology</subject><subject>Streptococcus agalactiae - immunology</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQgIMotVb_gcIeRNrDarJ57O5FkKK1UPCi55BNZmtkH5rpCv57U1t69DQzzDfDzEfIJaO3jDJ1RynN0pILPi3ErKSciZQekTGTUqY5U9kxGR-QU3KG-BFLWko1IiPFVVnm-ZjwZdsOXb9u-mpofJcskulyvZglOFS2MYiAielc8j60pkucRzAI5-SkNg3CxT5OyNvT4-v8OV29LJbzh1VqBZObNHPcCq6qvKJOmprFxFnIjQJKXcaLkmYWGKMgqhwkY05YpgwtlDCOS3B8Qm52ez9D_zUAbnTr0ULTmA76AXXB4jusyCIodqANPWKAWn8G35rwoxnVW1d6K0JvRehC6D9Xmsaxq_3-oWrBHYb2cmL_et83aE1TB9NZjweslLzIZRGx-x0G0cW3h6DReugsOB_AbrTr_f93_ALMZ4Na</recordid><startdate>19840330</startdate><enddate>19840330</enddate><creator>Oxelius, Vivi-Anne</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840330</creationdate><title>Immunoglobulin G (IgG) subclasses and human disease</title><author>Oxelius, Vivi-Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-2d3c436b7b0d5af1b7bdce7a6e00d238902ce110e4b7e511d4c16a0864ad35ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Antibodies, Heterophile - deficiency</topic><topic>Ataxia Telangiectasia - complications</topic><topic>Ataxia Telangiectasia - immunology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity - complications</topic><topic>Hypersensitivity - immunology</topic><topic>IgA Deficiency</topic><topic>IgG Deficiency</topic><topic>Immunization, Passive</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulin G - administration & dosage</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulinopathies</topic><topic>Immunologic Deficiency Syndromes - complications</topic><topic>Immunologic Deficiency Syndromes - immunology</topic><topic>Immunologic Deficiency Syndromes - therapy</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Medical sciences</topic><topic>Otitis Media - complications</topic><topic>Otitis Media - immunology</topic><topic>Rabbits</topic><topic>Streptococcal Infections - complications</topic><topic>Streptococcal Infections - immunology</topic><topic>Streptococcus agalactiae - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oxelius, Vivi-Anne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oxelius, Vivi-Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin G (IgG) subclasses and human disease</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1984-03-30</date><risdate>1984</risdate><volume>76</volume><issue>3</issue><spage>7</spage><epage>18</epage><pages>7-18</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>The isotypes of IgG, IgG
1, IgG
2, IgG
3, and IgG
4 were determined in immunoglobulin preparations and the effect on serum levels of treated patients. Serum IgG subclass deficiencies were recorded in different patient groups: (1) IgG
2–IgG
4 deficiency was associated with IgA deficiency. (2) IgG
2–IgG
4 deficiency was found in patients with ataxia telangiectasia. (3) Low IgG
2 levels were recorded in patients with SLE; one of these patients with recurrent pericarditis was treated with immunoglobulin with good results. (4) Low IgG
2 and/or low IgG
3 levels were found in patients with juvenile diabetes mellitus. (5) Mothers giving birth to severely group B streptococci infected infants showed low levels of IgG subclasses indicating that the newborns were IgG subclass deficient at birth. (6) In a prospective study of children with recurrent otitis media aged 12 and 32 months the IgG
2 levels were significantly reduced in the group with considerably high otitis proneness. In patients with IgG
2–IgG
4 deficiency, absence of antibodies to polysaccharide antigen teichoic acid and the protein antigen α-toxin of staphylococci was demonstrated. Imbalanced IgG subclass pattern with increased IgG
4 was recorded in patients with different diseases such as atopic diseases and also in combination with increased IgE, Henoch-Schönlein vasculitis, idiopathic pulmonary hemosiderosis, chronic mucocutaneous candidiasis, and in patients with Trichuris trichurea infection.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6369977</pmid><doi>10.1016/0002-9343(84)90314-0</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The American journal of medicine, 1984-03, Vol.76 (3), p.7-18 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Animals Antibodies, Heterophile - deficiency Ataxia Telangiectasia - complications Ataxia Telangiectasia - immunology Biological and medical sciences Child Child, Preschool Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - immunology Female Humans Hypersensitivity - complications Hypersensitivity - immunology IgA Deficiency IgG Deficiency Immunization, Passive Immunodeficiencies. Immunoglobulinopathies Immunoglobulin G - administration & dosage Immunoglobulin G - classification Immunoglobulinopathies Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - therapy Immunopathology Infant Infant, Newborn Lupus Erythematosus, Systemic - immunology Medical sciences Otitis Media - complications Otitis Media - immunology Rabbits Streptococcal Infections - complications Streptococcal Infections - immunology Streptococcus agalactiae - immunology |
| title | Immunoglobulin G (IgG) subclasses and human disease |
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