Modulation of the growth of transformed cells by human tumor necrosis factor-alpha and interferon-gamma

Recombinant human tumor necrosis factor-alpha (rHuTNF-alpha) inhibited growth of the cervical carcinoma cell line, ME-180neo, at doses greater than 50 units/ml, but stimulated the growth of these cells at low doses (0.1-10 units/ml). ME-180neo variants selected for resistance to the cytotoxic effect...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987-10, Vol.47 (20), p.5382-5385
Hauptverfasser:	Lewis, G D, Aggarwal, B B, Eessalu, T E, Sugarman, B J, Shepard, H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Division - drug effects Cell Line Cell Transformation, Neoplastic - drug effects Female Humans Interferon-gamma - pharmacology Kinetics Receptors, Cell Surface - metabolism Receptors, Tumor Necrosis Factor Recombinant Proteins - pharmacology Tumor Necrosis Factor-alpha - pharmacology Uterine Cervical Neoplasms - pathology
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