Increased transport of 3,4-dihydroxyphenylacetic acid from brain during performance of operant behavior in the rat
Although the performance of positively reinforced operant behavior is accompanied by increased turnover of brain dopamine in the rat, the accumulation of 3,4-dihydroxyphenylacetic acid (DOPAC), the major metabolic product of dopamine in brain, is not increased during operant performance. The hypothe...
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| Veröffentlicht in: | Brain research 1984-02, Vol.293 (1), p.85-91 |
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| creator | Heffner, Thomas G. Vosmer, Georgetta Seiden, Lewis S. |
| description | Although the performance of positively reinforced operant behavior is accompanied by increased turnover of brain dopamine in the rat, the accumulation of 3,4-dihydroxyphenylacetic acid (DOPAC), the major metabolic product of dopamine in brain, is not increased during operant performance. The hypothesis that the lack of increased DOPAC accumulation stems from an increase in the rate at which DOPAC is eliminated from the brain was tested by measuring the relative rate of DOPAC transport from brain in rats performing operant behavior and in control rats. The transport of DOPAC was estimated following inhibition of monoamine oxidase with pargyline. The pargyline-induced depletions of DOPAC in the caudate putamen and amygdala were significantly greater in rats that performed operant behavior than in control rats. In the caudate putamen, the concentrations of homovanillic acid and 5-hydroxyindoleacetic acid were also depleted by pargyline to a greater extent in operant performing rats than in controls. These results suggest that in addition to the increased turnover of dopamine in central neurons during operant behavior, the rate of elimination of acidic amine metabolites from brain is also accelerated. |
| doi_str_mv | 10.1016/0006-8993(84)91455-0 |
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The hypothesis that the lack of increased DOPAC accumulation stems from an increase in the rate at which DOPAC is eliminated from the brain was tested by measuring the relative rate of DOPAC transport from brain in rats performing operant behavior and in control rats. The transport of DOPAC was estimated following inhibition of monoamine oxidase with pargyline. The pargyline-induced depletions of DOPAC in the caudate putamen and amygdala were significantly greater in rats that performed operant behavior than in control rats. In the caudate putamen, the concentrations of homovanillic acid and 5-hydroxyindoleacetic acid were also depleted by pargyline to a greater extent in operant performing rats than in controls. These results suggest that in addition to the increased turnover of dopamine in central neurons during operant behavior, the rate of elimination of acidic amine metabolites from brain is also accelerated.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(84)91455-0</identifier><identifier>PMID: 6200185</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>3,4-dihydroxyphenylacetic acid ; 3,4-Dihydroxyphenylacetic Acid - metabolism ; Amygdala - analysis ; Animal ; Animals ; Biological and medical sciences ; brain ; Brain - metabolism ; Caudate Nucleus - analysis ; Conditioning ; Conditioning, Operant - physiology ; Dopamine - analysis ; dopamine metabolism ; Fundamental and applied biological sciences. Psychology ; Homovanillic Acid - analysis ; Hydroxyindoleacetic Acid - analysis ; Learning. Memory ; Male ; operant behavior ; operant conditioning ; Pargyline - pharmacology ; Phenylacetates - metabolism ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Putamen - analysis ; Rats</subject><ispartof>Brain research, 1984-02, Vol.293 (1), p.85-91</ispartof><rights>1984 Elsevier Science Publishers B.V., Amsterdam</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2245b3c6c6df8f71219b0a5bee04c47b575d6e9a0602a8334b55b702ccc7416d3</citedby><cites>FETCH-LOGICAL-c417t-2245b3c6c6df8f71219b0a5bee04c47b575d6e9a0602a8334b55b702ccc7416d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(84)91455-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9615895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6200185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heffner, Thomas G.</creatorcontrib><creatorcontrib>Vosmer, Georgetta</creatorcontrib><creatorcontrib>Seiden, Lewis S.</creatorcontrib><title>Increased transport of 3,4-dihydroxyphenylacetic acid from brain during performance of operant behavior in the rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Although the performance of positively reinforced operant behavior is accompanied by increased turnover of brain dopamine in the rat, the accumulation of 3,4-dihydroxyphenylacetic acid (DOPAC), the major metabolic product of dopamine in brain, is not increased during operant performance. The hypothesis that the lack of increased DOPAC accumulation stems from an increase in the rate at which DOPAC is eliminated from the brain was tested by measuring the relative rate of DOPAC transport from brain in rats performing operant behavior and in control rats. The transport of DOPAC was estimated following inhibition of monoamine oxidase with pargyline. The pargyline-induced depletions of DOPAC in the caudate putamen and amygdala were significantly greater in rats that performed operant behavior than in control rats. In the caudate putamen, the concentrations of homovanillic acid and 5-hydroxyindoleacetic acid were also depleted by pargyline to a greater extent in operant performing rats than in controls. These results suggest that in addition to the increased turnover of dopamine in central neurons during operant behavior, the rate of elimination of acidic amine metabolites from brain is also accelerated.</description><subject>3,4-dihydroxyphenylacetic acid</subject><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Amygdala - analysis</subject><subject>Animal</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Brain - metabolism</subject><subject>Caudate Nucleus - analysis</subject><subject>Conditioning</subject><subject>Conditioning, Operant - physiology</subject><subject>Dopamine - analysis</subject><subject>dopamine metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Homovanillic Acid - analysis</subject><subject>Hydroxyindoleacetic Acid - analysis</subject><subject>Learning. Memory</subject><subject>Male</subject><subject>operant behavior</subject><subject>operant conditioning</subject><subject>Pargyline - pharmacology</subject><subject>Phenylacetates - metabolism</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Putamen - analysis</subject><subject>Rats</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo67j6DxRyEFGwNd9JXxZk2dWFBS96Dumk2ol0d8ZKz-L8e7udYY56CkU9bxGel5CXnH3gjJuPjDHTuLaVb51613KldcMekQ13VjRGKPaYbM7IU_Ks1p_LKGXLLsiFEYxxpzcE76aIECokOmOY6q7gTEtP5XvVpLw9JCy_D7stTIchRJhzpCHmRHssI-0w5ImmPebpB90B9gXHMEVY82WZwzTTDrbhIRekCzlvgWKYn5MnfRgqvDi9l-T77c236y_N_dfPd9ef7puouJ0bIZTuZDTRpN71lgvedizoDoCpqGynrU4G2sAME8FJqTqtO8tEjNEqbpK8JG-Od3dYfu2hzn7MNcIwhAnKvnrHGbPW2P-CXDohuWALqI5gxFIrQu93mMeAB8-ZXzvxq3C_CvdO-b-d-DX26nR_342QzqFTCcv-9WkfagxDv4iLuZ6x1nDt2hW7OmKwSHvIgL7GDIvvlBHi7FPJ__7HH-IrqGE</recordid><startdate>19840213</startdate><enddate>19840213</enddate><creator>Heffner, Thomas G.</creator><creator>Vosmer, Georgetta</creator><creator>Seiden, Lewis S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19840213</creationdate><title>Increased transport of 3,4-dihydroxyphenylacetic acid from brain during performance of operant behavior in the rat</title><author>Heffner, Thomas G. ; Vosmer, Georgetta ; Seiden, Lewis S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2245b3c6c6df8f71219b0a5bee04c47b575d6e9a0602a8334b55b702ccc7416d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>3,4-dihydroxyphenylacetic acid</topic><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Amygdala - analysis</topic><topic>Animal</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Brain - metabolism</topic><topic>Caudate Nucleus - analysis</topic><topic>Conditioning</topic><topic>Conditioning, Operant - physiology</topic><topic>Dopamine - analysis</topic><topic>dopamine metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Homovanillic Acid - analysis</topic><topic>Hydroxyindoleacetic Acid - analysis</topic><topic>Learning. Memory</topic><topic>Male</topic><topic>operant behavior</topic><topic>operant conditioning</topic><topic>Pargyline - pharmacology</topic><topic>Phenylacetates - metabolism</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Putamen - analysis</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heffner, Thomas G.</creatorcontrib><creatorcontrib>Vosmer, Georgetta</creatorcontrib><creatorcontrib>Seiden, Lewis S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heffner, Thomas G.</au><au>Vosmer, Georgetta</au><au>Seiden, Lewis S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased transport of 3,4-dihydroxyphenylacetic acid from brain during performance of operant behavior in the rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1984-02-13</date><risdate>1984</risdate><volume>293</volume><issue>1</issue><spage>85</spage><epage>91</epage><pages>85-91</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Although the performance of positively reinforced operant behavior is accompanied by increased turnover of brain dopamine in the rat, the accumulation of 3,4-dihydroxyphenylacetic acid (DOPAC), the major metabolic product of dopamine in brain, is not increased during operant performance. The hypothesis that the lack of increased DOPAC accumulation stems from an increase in the rate at which DOPAC is eliminated from the brain was tested by measuring the relative rate of DOPAC transport from brain in rats performing operant behavior and in control rats. The transport of DOPAC was estimated following inhibition of monoamine oxidase with pargyline. The pargyline-induced depletions of DOPAC in the caudate putamen and amygdala were significantly greater in rats that performed operant behavior than in control rats. In the caudate putamen, the concentrations of homovanillic acid and 5-hydroxyindoleacetic acid were also depleted by pargyline to a greater extent in operant performing rats than in controls. These results suggest that in addition to the increased turnover of dopamine in central neurons during operant behavior, the rate of elimination of acidic amine metabolites from brain is also accelerated.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6200185</pmid><doi>10.1016/0006-8993(84)91455-0</doi><tpages>7</tpages></addata></record> |
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| subjects | 3,4-dihydroxyphenylacetic acid 3,4-Dihydroxyphenylacetic Acid - metabolism Amygdala - analysis Animal Animals Biological and medical sciences brain Brain - metabolism Caudate Nucleus - analysis Conditioning Conditioning, Operant - physiology Dopamine - analysis dopamine metabolism Fundamental and applied biological sciences. Psychology Homovanillic Acid - analysis Hydroxyindoleacetic Acid - analysis Learning. Memory Male operant behavior operant conditioning Pargyline - pharmacology Phenylacetates - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Putamen - analysis Rats |
| title | Increased transport of 3,4-dihydroxyphenylacetic acid from brain during performance of operant behavior in the rat |
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