Correlations of glucose metabolism and structural damage to language function in aphasia
Studies of aphasic patients using [ 18F]fluorodeoxyglucose positron computed tomographs have shown areas of metabolic depression in the left hemisphere larger than the area of infarction noted on CT. To evaluate these metabolic differences in relationship to language abnormalities, 11 patients had m...
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| Veröffentlicht in: | Brain and language 1984-03, Vol.21 (2), p.187-207 |
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| container_title | Brain and language |
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| creator | Metter, E.Jeffrey Riege, Walter H. Hanson, Wayne R. Camras, Lawrence R. Phelps, Michael E. Kuhl, David E. |
| description | Studies of aphasic patients using [
18F]fluorodeoxyglucose positron computed tomographs have shown areas of metabolic depression in the left hemisphere larger than the area of infarction noted on CT. To evaluate these metabolic differences in relationship to language abnormalities, 11 patients had metabolic scans, CT, and were administered the Boston Diagnostic Aphasia Battery and the Porch Index of Communicative Ability. Correlation analyses were computed between metabolic, CT, and language data. CT demonstrated reliable correlations of speaking, oral reading, and repetition to Wernicke' area, consistent with current anatomic language models, while metabolic data from areas posterior, inferior, and superior to the traditional Wernicke's area and the head of the caudate nucleus also had reliable correlations with aphasic language function. The utilization of both structural and metabolic brain measures may improve our understanding of the anatomy of language as related to aphasia. |
| doi_str_mv | 10.1016/0093-934X(84)90046-4 |
| format | Article |
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18F]fluorodeoxyglucose positron computed tomographs have shown areas of metabolic depression in the left hemisphere larger than the area of infarction noted on CT. To evaluate these metabolic differences in relationship to language abnormalities, 11 patients had metabolic scans, CT, and were administered the Boston Diagnostic Aphasia Battery and the Porch Index of Communicative Ability. Correlation analyses were computed between metabolic, CT, and language data. CT demonstrated reliable correlations of speaking, oral reading, and repetition to Wernicke' area, consistent with current anatomic language models, while metabolic data from areas posterior, inferior, and superior to the traditional Wernicke's area and the head of the caudate nucleus also had reliable correlations with aphasic language function. The utilization of both structural and metabolic brain measures may improve our understanding of the anatomy of language as related to aphasia.</description><identifier>ISSN: 0093-934X</identifier><identifier>EISSN: 1090-2155</identifier><identifier>DOI: 10.1016/0093-934X(84)90046-4</identifier><identifier>PMID: 6200176</identifier><identifier>CODEN: BRLGAZ</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Aged ; Aphasia - diagnosis ; Biological and medical sciences ; Blood Glucose - metabolism ; Brain Damage, Chronic - diagnostic imaging ; Brain Injuries - diagnostic imaging ; Brain Mapping ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Infarction - diagnostic imaging ; Deoxyglucose - analogs & derivatives ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Fluorodeoxyglucose F18 ; Humans ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropsychological Tests ; Tomography, Emission-Computed</subject><ispartof>Brain and language, 1984-03, Vol.21 (2), p.187-207</ispartof><rights>1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a534t-8747ec72c7ad43e7bd5f62781b3de4590f553eecd84123e9ead15b2c9cdc0fa13</citedby><cites>FETCH-LOGICAL-a534t-8747ec72c7ad43e7bd5f62781b3de4590f553eecd84123e9ead15b2c9cdc0fa13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0093-934X(84)90046-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27869,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9679451$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6200176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metter, E.Jeffrey</creatorcontrib><creatorcontrib>Riege, Walter H.</creatorcontrib><creatorcontrib>Hanson, Wayne R.</creatorcontrib><creatorcontrib>Camras, Lawrence R.</creatorcontrib><creatorcontrib>Phelps, Michael E.</creatorcontrib><creatorcontrib>Kuhl, David E.</creatorcontrib><title>Correlations of glucose metabolism and structural damage to language function in aphasia</title><title>Brain and language</title><addtitle>Brain Lang</addtitle><description>Studies of aphasic patients using [
18F]fluorodeoxyglucose positron computed tomographs have shown areas of metabolic depression in the left hemisphere larger than the area of infarction noted on CT. To evaluate these metabolic differences in relationship to language abnormalities, 11 patients had metabolic scans, CT, and were administered the Boston Diagnostic Aphasia Battery and the Porch Index of Communicative Ability. Correlation analyses were computed between metabolic, CT, and language data. CT demonstrated reliable correlations of speaking, oral reading, and repetition to Wernicke' area, consistent with current anatomic language models, while metabolic data from areas posterior, inferior, and superior to the traditional Wernicke's area and the head of the caudate nucleus also had reliable correlations with aphasic language function. The utilization of both structural and metabolic brain measures may improve our understanding of the anatomy of language as related to aphasia.</description><subject>Adult</subject><subject>Aged</subject><subject>Aphasia - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Brain Damage, Chronic - diagnostic imaging</subject><subject>Brain Injuries - diagnostic imaging</subject><subject>Brain Mapping</subject><subject>Cerebral Hemorrhage - diagnostic imaging</subject><subject>Cerebral Infarction - diagnostic imaging</subject><subject>Deoxyglucose - analogs & derivatives</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Tomography, Emission-Computed</subject><issn>0093-934X</issn><issn>1090-2155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNqFkUFrFTEUhYMo9Vn9BwoBRXQxmkySyWRTkEerhUI3FboLd5I7z5SZyTOZCP77zvgeb-FCV7lwv5ycnEPIa84-ccabz4wZURkh7z-08qNhTDaVfEI2nBlW1Vypp2RzQp6TFzk_MMa5bPkZOWvqZdbNhtxvY0o4wBzilGns6W4oLmakI87QxSHkkcLkaZ5TcXNJMFAPI-yQzpEOMO3KOvdlcqsCDROF_Q_IAV6SZz0MGV8dz3Py_erybvuturn9er39clOBEnKuWi01Ol07DV4K1J1XfVPrlnfCo1SG9UoJROdbyWuBBsFz1dXOOO9YD1yck_cH3X2KPwvm2Y4hOxwWbxhLti1nTC9P_RdULRdSylXx7V_gQyxpWj5heW0Ur7nQzULJA-VSzDlhb_cpjJB-W87s2o9dw7dr-LaV9k8_dnXx5iheuhH96dKxkGX_7riH7GDoE0wu5BNmGm2kWj1eHDBcov0VMNnsAk4OfUjoZutj-LePR5jVrE0</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>Metter, E.Jeffrey</creator><creator>Riege, Walter H.</creator><creator>Hanson, Wayne R.</creator><creator>Camras, Lawrence R.</creator><creator>Phelps, Michael E.</creator><creator>Kuhl, David E.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>JILTI</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7T9</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>198403</creationdate><title>Correlations of glucose metabolism and structural damage to language function in aphasia</title><author>Metter, E.Jeffrey ; Riege, Walter H. ; Hanson, Wayne R. ; Camras, Lawrence R. ; Phelps, Michael E. ; Kuhl, David E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a534t-8747ec72c7ad43e7bd5f62781b3de4590f553eecd84123e9ead15b2c9cdc0fa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aphasia - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Brain Damage, Chronic - diagnostic imaging</topic><topic>Brain Injuries - diagnostic imaging</topic><topic>Brain Mapping</topic><topic>Cerebral Hemorrhage - diagnostic imaging</topic><topic>Cerebral Infarction - diagnostic imaging</topic><topic>Deoxyglucose - analogs & derivatives</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metter, E.Jeffrey</creatorcontrib><creatorcontrib>Riege, Walter H.</creatorcontrib><creatorcontrib>Hanson, Wayne R.</creatorcontrib><creatorcontrib>Camras, Lawrence R.</creatorcontrib><creatorcontrib>Phelps, Michael E.</creatorcontrib><creatorcontrib>Kuhl, David E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 32</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><collection>Linguistics and Language Behavior Abstracts (LLBA)</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Brain and language</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metter, E.Jeffrey</au><au>Riege, Walter H.</au><au>Hanson, Wayne R.</au><au>Camras, Lawrence R.</au><au>Phelps, Michael E.</au><au>Kuhl, David E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlations of glucose metabolism and structural damage to language function in aphasia</atitle><jtitle>Brain and language</jtitle><addtitle>Brain Lang</addtitle><date>1984-03</date><risdate>1984</risdate><volume>21</volume><issue>2</issue><spage>187</spage><epage>207</epage><pages>187-207</pages><issn>0093-934X</issn><eissn>1090-2155</eissn><coden>BRLGAZ</coden><abstract>Studies of aphasic patients using [
18F]fluorodeoxyglucose positron computed tomographs have shown areas of metabolic depression in the left hemisphere larger than the area of infarction noted on CT. To evaluate these metabolic differences in relationship to language abnormalities, 11 patients had metabolic scans, CT, and were administered the Boston Diagnostic Aphasia Battery and the Porch Index of Communicative Ability. Correlation analyses were computed between metabolic, CT, and language data. CT demonstrated reliable correlations of speaking, oral reading, and repetition to Wernicke' area, consistent with current anatomic language models, while metabolic data from areas posterior, inferior, and superior to the traditional Wernicke's area and the head of the caudate nucleus also had reliable correlations with aphasic language function. The utilization of both structural and metabolic brain measures may improve our understanding of the anatomy of language as related to aphasia.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>6200176</pmid><doi>10.1016/0093-934X(84)90046-4</doi><tpages>21</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Brain and language, 1984-03, Vol.21 (2), p.187-207 |
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| language | eng |
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| source | MEDLINE; Periodicals Index Online; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Aphasia - diagnosis Biological and medical sciences Blood Glucose - metabolism Brain Damage, Chronic - diagnostic imaging Brain Injuries - diagnostic imaging Brain Mapping Cerebral Hemorrhage - diagnostic imaging Cerebral Infarction - diagnostic imaging Deoxyglucose - analogs & derivatives Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Fluorodeoxyglucose F18 Humans Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Neuropsychological Tests Tomography, Emission-Computed |
| title | Correlations of glucose metabolism and structural damage to language function in aphasia |
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