Improvement of myocardial function in diabetic rats after treatment with L-carnitine
The effects of L-carnitine administration on the severity of diabetes were investigated. Serum glucose, free fatty acids (FFA), triglycerides, and ketones from diabetic and normal rats injected for 2 weeks with 3 g/kg/d of either L-carnitine or saline were assayed. Hearts were analyzed for carnitine...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1984-01, Vol.33 (4), p.358-363 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Paulson, Dennis J. Schmidt, Mary J. Traxler, John S. Ramacci, Maria T. Shug, Austin L. |
| description | The effects of L-carnitine administration on the severity of diabetes were investigated. Serum glucose, free fatty acids (FFA), triglycerides, and ketones from diabetic and normal rats injected for 2 weeks with 3 g/kg/d of either L-carnitine or saline were assayed. Hearts were analyzed for carnitine and long-chain acyl coenzyme A. L-carnitine treatment to diabetic rats significantly reduced serum glucose, FFA, triglycerides, and ketones. In nondiabetic rats, carnitine increased serum ketones while FFA and triglycerides were decreased. L-carnitine treatment to diabetic rats prevented a decrease in myocardial total carnitine content. Long-chain acyl carnitine increased while long-chain acyl coenzyme A decreased. In another experiment, L-carnitine administration (750 mg/kg/d for 14 days) significantly improved the recovery of cardiac output after 60, 90, and 120 minutes of ischemia in diabetic perfused hearts. These results suggest that L-carnitine therapy may reduce the severity of diabetes mellitus and improve myocardial performance. |
| doi_str_mv | 10.1016/0026-0495(84)90199-9 |
| format | Article |
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Serum glucose, free fatty acids (FFA), triglycerides, and ketones from diabetic and normal rats injected for 2 weeks with 3 g/kg/d of either L-carnitine or saline were assayed. Hearts were analyzed for carnitine and long-chain acyl coenzyme A. L-carnitine treatment to diabetic rats significantly reduced serum glucose, FFA, triglycerides, and ketones. In nondiabetic rats, carnitine increased serum ketones while FFA and triglycerides were decreased. L-carnitine treatment to diabetic rats prevented a decrease in myocardial total carnitine content. Long-chain acyl carnitine increased while long-chain acyl coenzyme A decreased. In another experiment, L-carnitine administration (750 mg/kg/d for 14 days) significantly improved the recovery of cardiac output after 60, 90, and 120 minutes of ischemia in diabetic perfused hearts. These results suggest that L-carnitine therapy may reduce the severity of diabetes mellitus and improve myocardial performance.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(84)90199-9</identifier><identifier>PMID: 6708820</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - analysis ; Carnitine - metabolism ; Carnitine - therapeutic use ; Coenzyme A - metabolism ; Coronary Disease - metabolism ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Fatty Acids, Nonesterified - blood ; Heart - drug effects ; Ketones - blood ; Male ; Medical sciences ; Myocardium - metabolism ; Perfusion ; Rats ; Rats, Inbred Strains ; Triglycerides - blood</subject><ispartof>Metabolism, clinical and experimental, 1984-01, Vol.33 (4), p.358-363</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-8210916978f6cf3b68e629783a91d59e46055a20f64ed96b5b88f8a8c3de18e3</citedby><cites>FETCH-LOGICAL-c415t-8210916978f6cf3b68e629783a91d59e46055a20f64ed96b5b88f8a8c3de18e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0026-0495(84)90199-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9006230$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6708820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paulson, Dennis J.</creatorcontrib><creatorcontrib>Schmidt, Mary J.</creatorcontrib><creatorcontrib>Traxler, John S.</creatorcontrib><creatorcontrib>Ramacci, Maria T.</creatorcontrib><creatorcontrib>Shug, Austin L.</creatorcontrib><title>Improvement of myocardial function in diabetic rats after treatment with L-carnitine</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The effects of L-carnitine administration on the severity of diabetes were investigated. Serum glucose, free fatty acids (FFA), triglycerides, and ketones from diabetic and normal rats injected for 2 weeks with 3 g/kg/d of either L-carnitine or saline were assayed. Hearts were analyzed for carnitine and long-chain acyl coenzyme A. L-carnitine treatment to diabetic rats significantly reduced serum glucose, FFA, triglycerides, and ketones. In nondiabetic rats, carnitine increased serum ketones while FFA and triglycerides were decreased. L-carnitine treatment to diabetic rats prevented a decrease in myocardial total carnitine content. Long-chain acyl carnitine increased while long-chain acyl coenzyme A decreased. In another experiment, L-carnitine administration (750 mg/kg/d for 14 days) significantly improved the recovery of cardiac output after 60, 90, and 120 minutes of ischemia in diabetic perfused hearts. These results suggest that L-carnitine therapy may reduce the severity of diabetes mellitus and improve myocardial performance.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Carnitine - metabolism</subject><subject>Carnitine - therapeutic use</subject><subject>Coenzyme A - metabolism</subject><subject>Coronary Disease - metabolism</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Heart - drug effects</subject><subject>Ketones - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardium - metabolism</subject><subject>Perfusion</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Triglycerides - blood</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWqv_QCEHET2sTvYjTS6CFL-g4KX3kM1OMLKb1SRV_PemtvToKUzmeSeZh5AzBjcMGL8FKHkBtWyuRH0tgUlZyD0yYU1VFoID7JPJDjkixzG-A8BsJvghOeQzEKKECVm-DB9h_MIBfaKjpcPPaHTonO6pXXmT3Oip8zRftJicoUGnSLVNGGgKqNNf7tulN7ooctC75DyekAOr-4in23NKlo8Py_lzsXh9epnfZ7JmTSpEyUAyLmfCcmOrlgvkZa4qLVnXSKw5NI0uwfIaO8nbphXCCi1M1SETWE3J5WZs3uBzhTGpwUWDfa89jquoBAPgXLAM1hvQhDHGgFZ9BDfo8KMYqLVLtRal1qKUqNWfSyVz7Hw7f9UO2O1CW3m5f7Ht62h0b4P2xsUdJvPrZbXG7jYYZhVfDoOKxqE32LmAJqludP__4xc8do-4</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Paulson, Dennis J.</creator><creator>Schmidt, Mary J.</creator><creator>Traxler, John S.</creator><creator>Ramacci, Maria T.</creator><creator>Shug, Austin L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Improvement of myocardial function in diabetic rats after treatment with L-carnitine</title><author>Paulson, Dennis J. ; Schmidt, Mary J. ; Traxler, John S. ; Ramacci, Maria T. ; Shug, Austin L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-8210916978f6cf3b68e629783a91d59e46055a20f64ed96b5b88f8a8c3de18e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Carnitine - metabolism</topic><topic>Carnitine - therapeutic use</topic><topic>Coenzyme A - metabolism</topic><topic>Coronary Disease - metabolism</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes. 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Serum glucose, free fatty acids (FFA), triglycerides, and ketones from diabetic and normal rats injected for 2 weeks with 3 g/kg/d of either L-carnitine or saline were assayed. Hearts were analyzed for carnitine and long-chain acyl coenzyme A. L-carnitine treatment to diabetic rats significantly reduced serum glucose, FFA, triglycerides, and ketones. In nondiabetic rats, carnitine increased serum ketones while FFA and triglycerides were decreased. L-carnitine treatment to diabetic rats prevented a decrease in myocardial total carnitine content. Long-chain acyl carnitine increased while long-chain acyl coenzyme A decreased. In another experiment, L-carnitine administration (750 mg/kg/d for 14 days) significantly improved the recovery of cardiac output after 60, 90, and 120 minutes of ischemia in diabetic perfused hearts. These results suggest that L-carnitine therapy may reduce the severity of diabetes mellitus and improve myocardial performance.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6708820</pmid><doi>10.1016/0026-0495(84)90199-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Blood Glucose - analysis Carnitine - metabolism Carnitine - therapeutic use Coenzyme A - metabolism Coronary Disease - metabolism Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fatty Acids, Nonesterified - blood Heart - drug effects Ketones - blood Male Medical sciences Myocardium - metabolism Perfusion Rats Rats, Inbred Strains Triglycerides - blood |
| title | Improvement of myocardial function in diabetic rats after treatment with L-carnitine |
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