Dose and flow dependence of 5-fluorouracil elimination by the isolated perfused rat liver

The influences of dose and hepatic blood flow on the elimination of 5-fluorouracil (FUra) by the isolated perfused rat liver were investigated. FUra was injected into the perfusion reservoir and then serial blood samples were collected over 2-3 h. FUra concentration was determined chromatographicall...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987-10, Vol.47 (20), p.5261-5265
Hauptverfasser:	WARREN, B. S, LACRETA, F. P, KORNHAUSER, D. M, WILLIAMS, W. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Dose-Response Relationship, Drug Fluorouracil - pharmacokinetics General aspects Kinetics Liver - blood supply Liver - metabolism Medical sciences Perfusion Pharmacology. Drug treatments Rats Regional Blood Flow Time Factors
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