Use of intravenous immune globulin in pregnant women with common variable hypogammaglobulinemia

Two patients with common variable hypogammaglobulinemia were treated with immune serum globulin during pregnancy. An intravenous immune serum globulin preparation was used in the last trimester of pregnancy. Both patients tolerated this preparation well and had an uneventful pregnancy. The two term...

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Veröffentlicht in:The American journal of medicine 1984-03, Vol.76 (3), p.73-77
Hauptverfasser: Sorensen, Ricardo U., Tomford, J.Walton, Gyves, Michael T., Judge, Nancy E., Polmar, Stephen H.
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container_end_page 77
container_issue 3
container_start_page 73
container_title The American journal of medicine
container_volume 76
creator Sorensen, Ricardo U.
Tomford, J.Walton
Gyves, Michael T.
Judge, Nancy E.
Polmar, Stephen H.
description Two patients with common variable hypogammaglobulinemia were treated with immune serum globulin during pregnancy. An intravenous immune serum globulin preparation was used in the last trimester of pregnancy. Both patients tolerated this preparation well and had an uneventful pregnancy. The two term newborns were healthy and had cord blood IgG levels likely to be the result of transplacental transfer of the intravenous immune serum globulin preparation. During pregnancy there is an increase in the IgG distribution space due to plasma volume expansion. Therefore, pregnancy is an indication for these immune serum globulin preparations that can be administered at high doses intravenously in order to confer adequate protection to the mother and the newborn.
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subjects Adolescent
Adult
Agammaglobulinemia - immunology
Agammaglobulinemia - physiopathology
Agammaglobulinemia - therapy
Biological and medical sciences
Female
Fetal Blood - immunology
Humans
Immunity, Maternally-Acquired
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin G - administration & dosage
Immunoglobulin G - analogs & derivatives
Immunoglobulin G - metabolism
Immunoglobulinopathies
Immunoglobulins, Intravenous
Immunopathology
Infant
Infant, Newborn
Medical sciences
Pregnancy
Pregnancy Complications - immunology
Pregnancy Complications - therapy
title Use of intravenous immune globulin in pregnant women with common variable hypogammaglobulinemia
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