Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone

Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone

Cytotoxic T-cell clones raised against X-31 (H3N2) influenza virus in C57BL/6 mice can be directed against an influenza A virus subtype specific determinant ( 1). A representative T-cell clone (A3.1) has been used in combination with a set of genetically typed recombinant viruses, to show that the A...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1984-03, Vol.133 (2), p.456-459
Hauptverfasser: Townsend, A.R.M., Skehel, J.J., Taylor, P.M., Palese, P.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Cell interactions
Clone Cells
Cloning, Molecular
Epitopes - analysis
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Genes, Viral
H-2 Antigens - genetics
Immunobiology
Influenza A virus - genetics
Influenza A virus - immunology
Mice
Mice, Inbred C57BL
Nucleoproteins - genetics
T-Lymphocytes, Cytotoxic - immunology
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Zusammenfassung:Cytotoxic T-cell clones raised against X-31 (H3N2) influenza virus in C57BL/6 mice can be directed against an influenza A virus subtype specific determinant ( 1). A representative T-cell clone (A3.1) has been used in combination with a set of genetically typed recombinant viruses, to show that the A/PR/8/34 nucleoprotein can be responsible for cytotoxic T-lymphocyte recognition of infected target cells.
ISSN:0042-6822
1096-0341
DOI:10.1016/0042-6822(84)90413-6