Mechanism of inhibition of polypeptide chain initiation in heat‐shocked Ehrlich ascites tumour cells

The rate of polypeptide synthesis is inhibited by 80% in Ehrlich cells incubated at 43°C compared to those at 37°C. The regulatory site of translation resides at polypeptide chain initiation. Polypeptide synthesis does not recover at the higher temperature; however, the inhibition is reversed by ret...

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