$Comparison of 3α-hydroxysteroid dehydrogenase activities in the microsomal fractions of hyperplastic, malignant and normal human prostatic tissues$

Comparison of 3α-hydroxysteroid dehydrogenase activities in the microsomal fractions of hyperplastic, malignant and normal human prostatic tissues

The conversion of dihydrotestosterone (DHT) to 3α-androstanediol (3α-adiol) was studied using the microsomal fractions of 15 hyperplastic, 5 malignant and 6 normal human prostatic tissues. Standard assay conditions were: 0.2 μ M DHT, 1.0 mM NADPH, 1.0 mM NADH, 2.0 mM EDTA and the microsomal fraction...

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Veröffentlicht in:	Journal of steroid biochemistry 1984-04, Vol.20 (4), p.829-833
1. Verfasser:	Hudson, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) 3-Hydroxysteroid Dehydrogenases - metabolism Biological and medical sciences Cations, Divalent Edetic Acid - pharmacology Humans Kinetics Male Medical sciences Microsomes - enzymology Nephrology. Urinary tract diseases Prostate - enzymology Prostatic Hyperplasia - enzymology Prostatic Neoplasms - enzymology Reference Values Tumors of the urinary system Urinary tract. Prostate gland
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